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Image Search Results


Brain tissue from human AD (A) and from 5xFAD, App SAA/SAA , App NLG/NLG , and App NLG/NLG :APOE4 mice (B-D) were stained for fibrin(ogen) (red), Aβ (blue), and the microglia marker Iba1 (green) primary antibodies (scale bar, 25 mm). ( A ) In AD brain tissue, fibrin(ogen) deposition was found within amyloid plaques (#), diffusely around some of the blood vessels (*), and decorating blood vessels (arrowheads). Representative images are shown from n = 3 samples. ( B ) 10-month-old 5xFAD mice showed robust fibrin(ogen) deposition within and around amyloid plaques and decorating blood vessels (arrowheads). Reactive microglia (green) accumulated around amyloid and fibrin(ogen) deposits. Representative images are shown from n = 10 samples. ( C, D ) Relative to 5xFAD mice (B), 21-month-old App NLG/NLG (C) and 15-month-old App NLG/NLG :APOE4 (D) mice showed more diffuse fibrin(ogen) deposition around amyloid plaques, with fibrin(ogen) forming an external halo around amyloid plaques. Reactive microglia cells (green) accumulated around amyloid and fibrin(ogen) deposits. Representative images are shown from n = 6–10 samples per genotype.

Journal: bioRxiv

Article Title: Therapeutic targeting of fibrin–microglia interactions ameliorates Alzheimer’s disease-related hyperexcitability and brain network dysfunction

doi: 10.64898/2026.05.01.722324

Figure Lengend Snippet: Brain tissue from human AD (A) and from 5xFAD, App SAA/SAA , App NLG/NLG , and App NLG/NLG :APOE4 mice (B-D) were stained for fibrin(ogen) (red), Aβ (blue), and the microglia marker Iba1 (green) primary antibodies (scale bar, 25 mm). ( A ) In AD brain tissue, fibrin(ogen) deposition was found within amyloid plaques (#), diffusely around some of the blood vessels (*), and decorating blood vessels (arrowheads). Representative images are shown from n = 3 samples. ( B ) 10-month-old 5xFAD mice showed robust fibrin(ogen) deposition within and around amyloid plaques and decorating blood vessels (arrowheads). Reactive microglia (green) accumulated around amyloid and fibrin(ogen) deposits. Representative images are shown from n = 10 samples. ( C, D ) Relative to 5xFAD mice (B), 21-month-old App NLG/NLG (C) and 15-month-old App NLG/NLG :APOE4 (D) mice showed more diffuse fibrin(ogen) deposition around amyloid plaques, with fibrin(ogen) forming an external halo around amyloid plaques. Reactive microglia cells (green) accumulated around amyloid and fibrin(ogen) deposits. Representative images are shown from n = 6–10 samples per genotype.

Article Snippet: App SAA mice were obtained from The Jackson Laboratory (Jax 034711).

Techniques: Staining, Marker