rat antimouse cd68 monoclonal antibody (Bio-Rad)
Structured Review

Rat Antimouse Cd68 Monoclonal Antibody, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 96/100, based on 3271 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rat+antimouse+cd68/Rat+anti+Mouse+CD68/pmc12084789-128-15-20
Average 96 stars, based on 3271 article reviews
Images
1) Product Images from "Endogenous Recovery of Hippocampal Function Following Global Cerebral Ischemia in Juvenile Female Mice Is Influenced by Neuroinflammation and Circulating Sex Hormones"
Article Title: Endogenous Recovery of Hippocampal Function Following Global Cerebral Ischemia in Juvenile Female Mice Is Influenced by Neuroinflammation and Circulating Sex Hormones
Journal: Neural Plasticity
doi: 10.1155/np/6103242
Figure Legend Snippet: Transcriptional analysis of the observed recovery of hippocampal function in . (A) Venn diagram depicting the number of transcripts differentially expressed 7 days after CA/CPR (left) or 30 days after CA/CPR (right). Lower venn diagram depicts the number of transcripts that were altered by CA/CPR at 7-day and recover by 30 days. (B) Bar graph depicting a total of 31 transcripts from (A) had greater than 2-fold change in expression. (C) STRING protein–protein interaction network of the 31 transcripts in (B) revealing Cd68, Spi1, and Trem2 as a central regulator of the altered transcripts. (D) Lollipop plot depicting the 10 pathways that are most affected by CA/CPR and subsequent recover by 30 days after CA/CPR.
Techniques Used: Expressing
Figure Legend Snippet: Protein expression levels of CD68 mirror the transcriptional data. Representative images of DAPI (blue), Iba1 (red), and CD68 (green) staining in the CA1 region of the hippocampus in 7d Sham animals (A), 7d CA/CPR animals (B), 30d Sham animals (C), and 30d CA/CPR animals (D). Quantification of protein expression of CD68 from confocal images (E). ( ∗∗∗ = p < 0.001, GLMM).
Techniques Used: Expressing, Staining
Figure Legend Snippet: GCI induced transcriptional changes associated with GCI induced post and presynaptic plasticity alterations. (A) CD68 mRNA is increased 7 days after CA/CPR with a recovery of expression to sham levels by 30 days post-CA/CPR. Removal of gonadal sex hormones allows CD68 expression levels to remain elevated 30 days after CA/CPR. ( ∗ = p < 0.05, ∗∗∗ = p < 0.001, One-way ANOVA) (B) N -type calcium channel transcripts are significantly elevated by CA/CPR at all time points despite recovery of hippocampal LTP. ( ∗ = p < 0.05, One-way ANOVA).
Techniques Used: Expressing
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