human burkitt s lymphoma ramos (ATCC)
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Human Burkitt S Lymphoma Ramos, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 83 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ramos+ra+1/Ramos+(RA+1)%3B+Burkitt's+Lymphoma%3B+Human/pmc11611760-93-0-7
Average 95 stars, based on 83 article reviews
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1) Product Images from "The novel and potent CD40 agonist KHK2840 augments the antitumor efficacy of anti‐ PD ‐1 antibody and paclitaxel"
Article Title: The novel and potent CD40 agonist KHK2840 augments the antitumor efficacy of anti‐ PD ‐1 antibody and paclitaxel
Journal: Cancer Science
doi: 10.1111/cas.16366
Figure Legend Snippet: KHK2840 is a novel human CD40 agonist. (A) Representative sensorgrams of hCD40 (left), cynomolgus monkey CD40 (middle left), rat CD40 (middle; right), and mouse CD40 (right) to KHK2840. KHK2840 was captured on the sensor chip immobilized with anti‐human IgG, and then dilutions of recombinant CD40 proteins (0.0625, 0.125, 0.250, 0.500, 1.00 μg/mL) were injected. (B) KHK2840 (red), isotype control (human anti‐DNP IgG2, gray), and positive control (human anti‐DNP IgG1, blue) bind to FcγRIIIa (left, 158F; middle, 158 V) and C1q. Data represent the mean ± SD of three experiments. (C) The in vitro expression of CD80, CD86, and IL‐12p70 in hmoDCs induced by KHK2840 (red) and isotype control (human anti‐DNP IgG2, gray). In IL‐12p70, values below the lower limit of quantification (LLOQ) were replaced with the LLOQ. Data represent the mean ± SD of three wells. The same experiments were repeated in a total of six donors. (D) The in vitro expression of CD86 and CD95 induced in Ramos cells by 0.01 (filled circle), 0.1 (blank circle), 1 (filled square) and 10 μg/mL (blank square) KHK2840 after 0.5, 4, 24, and 48 h of treatment. KHK2840 was washed out at the indicated time points. Cells were analyzed after a total of 48 h of incubation. Data represent the mean ± SD of three wells.
Techniques Used: Recombinant, Injection, Control, Positive Control, In Vitro, Expressing, Incubation
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