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prepulse inhibition  (Columbus Instruments)


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    Columbus Instruments prepulse inhibition
    Prepulse Inhibition, supplied by Columbus Instruments, used in various techniques. Bioz Stars score: 91/100, based on 40 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/prepulse+inhibition/Startle+Response+Meter+Responder+X/pm35748629-78-5-16
    Average 91 stars, based on 40 article reviews
    prepulse inhibition - by Bioz Stars, 2026-10
    91/100 stars

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    Related Articles

    Inhibition:

    Article Title: Neonatal ventral hippocampus lesion disrupts maternal behavior in rats: An animal model of schizophrenia.
    Article Snippet: 1Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico 2Maestría en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico 3Centro de Investigación en Reproducción Animal, CINVESTAV Laboratorio Tlaxcala, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico 4Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Mexico 5Laboratorio de Neuropsiquiatría, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico 6Doctorado en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico

    Article Title: Comparative investigation of behavioral, neurotoxicological, and immunotoxicological indices in detection of subacute combined exposure with methyl parathion and propoxur in rats
    Article Snippet: .. The acoustic startle response (ASR) and prepulse inhibition were measured following the OF test, on the same day, using ResponderX (Columbus Instruments, Columbus, OH, USA) equipment. ..



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    Fig. 3. Effects of HU-910 pretreatment on MK-801 and amphetamine-induced <t>PPI</t> disruption. (A) The disruptive effect of MK-801 treatment (0.25 mg/kg) in the PPI was attenuated by HU-910 (30 mg/kg) in all <t>prepulse</t> intensities. *p < 0.05 compared to vehicle+saline group (n = 9/group). (B) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment (C). Effect of HU-910 pretreatment on amphetamine-induced PPI disruption. The disruptive effect of amphetamine treatment (5 mg/kg) in the PPI was attenuated by HU-910 treatment at all doses tested on 80 dB prepulse intensity. On 85 dB and 90 dB prepulse intensities, HU-910 pretreatment attenuated PPI disruption only ate the dose of 3 mg/kg *p < 0.05 compared to vehicle+saline group (n = 10/group). (D) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment. Repeated-measures ANOVA followed by Turkey's test.
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    Timeline of the behavioral tests. Each animal completed all behavioral tests, except for Phenotyper that was performed only for a subset of animals: Phenotyper—myoclonus detection; CatWalk—walking pattern (coordination), speed of walk; Startle—startle response, prepulse inhibition; Beam walk—coordination; Elevated plus maze—hyperactivity, speed of walk; Grip strength—strength.

    Journal: Frontiers in Behavioral Neuroscience

    Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

    doi: 10.3389/fnbeh.2023.1325051

    Figure Lengend Snippet: Timeline of the behavioral tests. Each animal completed all behavioral tests, except for Phenotyper that was performed only for a subset of animals: Phenotyper—myoclonus detection; CatWalk—walking pattern (coordination), speed of walk; Startle—startle response, prepulse inhibition; Beam walk—coordination; Elevated plus maze—hyperactivity, speed of walk; Grip strength—strength.

    Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

    Techniques: Inhibition

    Cstb −/− mice show progressive myoclonus and altered startle response. (A) Myoclonic events were detected in PhenoTyper cages for a period of 3 h at 1.5, 3, and 6 months of age. (B) Progression of myoclonic events from 1.5 to 6 months of age in individual animals (see for separate graphs of Cstb −/− mice). (C) Cstb −/− mice show reduced startle response to 100 dB noise at 3, 5, and 6 months of age compared to the wild type ( wt ) mice. (D–F) Prepulse inhibition (PPI) at 69, 73, and 77 dB prepulse intensities is decreased in Cstb −/− mice at the age of 3 (D) , 5 (E) , and 6 (F) months. Data are presented as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001, N = 12 for (A,B) , N = 15–16 for (C–F) .

    Journal: Frontiers in Behavioral Neuroscience

    Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

    doi: 10.3389/fnbeh.2023.1325051

    Figure Lengend Snippet: Cstb −/− mice show progressive myoclonus and altered startle response. (A) Myoclonic events were detected in PhenoTyper cages for a period of 3 h at 1.5, 3, and 6 months of age. (B) Progression of myoclonic events from 1.5 to 6 months of age in individual animals (see for separate graphs of Cstb −/− mice). (C) Cstb −/− mice show reduced startle response to 100 dB noise at 3, 5, and 6 months of age compared to the wild type ( wt ) mice. (D–F) Prepulse inhibition (PPI) at 69, 73, and 77 dB prepulse intensities is decreased in Cstb −/− mice at the age of 3 (D) , 5 (E) , and 6 (F) months. Data are presented as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001, N = 12 for (A,B) , N = 15–16 for (C–F) .

    Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

    Techniques: Inhibition

    Comparison of the symptoms in EPM1 patients and in Cstb −/− mice.

    Journal: Frontiers in Behavioral Neuroscience

    Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

    doi: 10.3389/fnbeh.2023.1325051

    Figure Lengend Snippet: Comparison of the symptoms in EPM1 patients and in Cstb −/− mice.

    Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

    Techniques: Comparison, Inhibition

    Fig. 3. Effects of HU-910 pretreatment on MK-801 and amphetamine-induced PPI disruption. (A) The disruptive effect of MK-801 treatment (0.25 mg/kg) in the PPI was attenuated by HU-910 (30 mg/kg) in all prepulse intensities. *p < 0.05 compared to vehicle+saline group (n = 9/group). (B) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment (C). Effect of HU-910 pretreatment on amphetamine-induced PPI disruption. The disruptive effect of amphetamine treatment (5 mg/kg) in the PPI was attenuated by HU-910 treatment at all doses tested on 80 dB prepulse intensity. On 85 dB and 90 dB prepulse intensities, HU-910 pretreatment attenuated PPI disruption only ate the dose of 3 mg/kg *p < 0.05 compared to vehicle+saline group (n = 10/group). (D) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment. Repeated-measures ANOVA followed by Turkey's test.

    Journal: Progress in neuro-psychopharmacology & biological psychiatry

    Article Title: HU-910, a CB2 receptor agonist, reverses behavioral changes in pharmacological rodent models for schizophrenia.

    doi: 10.1016/j.pnpbp.2022.110553

    Figure Lengend Snippet: Fig. 3. Effects of HU-910 pretreatment on MK-801 and amphetamine-induced PPI disruption. (A) The disruptive effect of MK-801 treatment (0.25 mg/kg) in the PPI was attenuated by HU-910 (30 mg/kg) in all prepulse intensities. *p < 0.05 compared to vehicle+saline group (n = 9/group). (B) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment (C). Effect of HU-910 pretreatment on amphetamine-induced PPI disruption. The disruptive effect of amphetamine treatment (5 mg/kg) in the PPI was attenuated by HU-910 treatment at all doses tested on 80 dB prepulse intensity. On 85 dB and 90 dB prepulse intensities, HU-910 pretreatment attenuated PPI disruption only ate the dose of 3 mg/kg *p < 0.05 compared to vehicle+saline group (n = 10/group). (D) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment. Repeated-measures ANOVA followed by Turkey's test.

    Article Snippet: The prepulse inhibition (PPI) test was performed simultaneously on two identical startle response systems (Med Associates, USA) with a constant 65 dB background noise.

    Techniques: Disruption, Saline, Modification