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Mimetics poly(sss) heparin mimetics
Poly(sss) Heparin Mimetics, supplied by Mimetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/poly(a)-tail+mimetics/poly+sss++heparin+mimetics/pm33533245-65-2-4
Average 90 stars, based on 1 article reviews
poly(sss) heparin mimetics - by Bioz Stars, 2026-10
90/100 stars

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Blocking Assay:

Article Title: Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months
Article Snippet: The first starting material, bicyclic pyrrolidine , can be prepared from Boc-protected bicyclic pyrrolidine acid , which was first reported by Madalengoitia in 1999 in his studies of poly- l -proline type-II (PPII) secondary structure mimetics ( Figure a)., It was prepared from l -pyroglutamic acid via the tricyclic N , O -acetal .

Article Title: Unified N -Sulfonylated Urea Catalyzed Enantioselective Dimerization, Arylation, and Amination of Tryptamines: Total Synthesis of Five Pyrroloindoline Alkaloids.
Article Snippet: Direct oxidative dimerization reactions of tryptamine monomers are biosynthetic pathways that straightforwardly lead to dimeric and oligomeric pyrroloindoline alkaloids that display a diverse range of valuable bioactivities.. However, catalytic enantioselective dimerizations have remained a long-standing challenge in asymmetric synthesis due to the difficulties in controlling the radical recombination process of transient singleelectron oxidized tryptamines and the formation of a sterically congested all-carbon quaternary stereocenter.. Here, we present a strategy that employs catalytic enantioselective dearomative iodocyclization/dimerization cascades to achieve asymmetric oxidative dimerizations of tryptamines.

Article Title: Reconstitution of the Early Stage of Chetomin Biosynthesis in Aspergillus fumigatus Leads to the Production of Epipolythiodioxopiperazines.
Article Snippet: Using CRISPR-Cas9 technology and a microhomology-mediated end-joining repair system, we substituted genes of the gliotoxin pathway in Aspergillus fumigatus with genes responsible for chetomin biosynthesis from Chaetomium cochliodes, leading to the production of three new epipolythiodioxopiperazines (ETPs).. This work represents the first successful endeavor to produce ETPs in a non-native host.. Additionally, the simultaneous disruption of five genes in a single transformation marks the most extensive gene knockout event in filamentous fungi to date.

Article Title: Monoclonal antibodies against NKG2A
Article Snippet: Examples of immunomodulating compounds include but are not limited to ligands of NOD and PKR receptors, agonists of TLRs (Toll-like receptor), such as agonists of TLR3 (dsRNA, poly I:C and poly A:U), TLR4 (ANA380, isatoribine, LPS and mimetics such as MPL), TLR7 (oligonucleotides, ssRNA), TLR9 (oligonucleotides such as CpGs), a number of examples of which are described in Akira and Takeda ((2004) Nature Reviews 4: 499), and antibodies that block inhibitory receptors on NK cells (for example that inhibit KIR2DL1 and KIR2DL2/3 activity) or act as agonists at NK cell activatory receptors (for example antibodies that crosslink NCR receptors NKp30, NKp44 or NK046).

Article Title: Monoclonal antibodies against NKG2A
Article Snippet: Examples of immunomodulating compounds include but are not limited to ligands of NOD and PKR receptors, agonists of TLRs (Toll-like receptors), such as agonists of TLR3 (dsRNA, poly I:C and poly A:U), TLR4 (ANA380, isatoribine, LPS and mimetics such as MPL), TLR7 (oligonucleotides, ssRNA), TLR9 (oligonucleotides such as CpGs), a number of examples of which are described in Akira and Takeda ((2004) Nature Reviews 4: 499), and antibodies that block inhibitory receptors on NK cells (for example that inhibit KIR2DL1 and KIR2DL2/3 activity) or act as agonists at NK cell activatory receptors (for example antibodies that crosslink NCR receptors NKp30, NKp44 or NKp46).

Activity Assay:

Article Title: Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months
Article Snippet: The first starting material, bicyclic pyrrolidine , can be prepared from Boc-protected bicyclic pyrrolidine acid , which was first reported by Madalengoitia in 1999 in his studies of poly- l -proline type-II (PPII) secondary structure mimetics ( Figure a)., It was prepared from l -pyroglutamic acid via the tricyclic N , O -acetal .

Article Title: Unified N -Sulfonylated Urea Catalyzed Enantioselective Dimerization, Arylation, and Amination of Tryptamines: Total Synthesis of Five Pyrroloindoline Alkaloids.
Article Snippet: Direct oxidative dimerization reactions of tryptamine monomers are biosynthetic pathways that straightforwardly lead to dimeric and oligomeric pyrroloindoline alkaloids that display a diverse range of valuable bioactivities.. However, catalytic enantioselective dimerizations have remained a long-standing challenge in asymmetric synthesis due to the difficulties in controlling the radical recombination process of transient singleelectron oxidized tryptamines and the formation of a sterically congested all-carbon quaternary stereocenter.. Here, we present a strategy that employs catalytic enantioselective dearomative iodocyclization/dimerization cascades to achieve asymmetric oxidative dimerizations of tryptamines.

Article Title: Reconstitution of the Early Stage of Chetomin Biosynthesis in Aspergillus fumigatus Leads to the Production of Epipolythiodioxopiperazines.
Article Snippet: Using CRISPR-Cas9 technology and a microhomology-mediated end-joining repair system, we substituted genes of the gliotoxin pathway in Aspergillus fumigatus with genes responsible for chetomin biosynthesis from Chaetomium cochliodes, leading to the production of three new epipolythiodioxopiperazines (ETPs).. This work represents the first successful endeavor to produce ETPs in a non-native host.. Additionally, the simultaneous disruption of five genes in a single transformation marks the most extensive gene knockout event in filamentous fungi to date.

Article Title: Monoclonal antibodies against NKG2A
Article Snippet: Examples of immunomodulating compounds include but are not limited to ligands of NOD and PKR receptors, agonists of TLRs (Toll-like receptor), such as agonists of TLR3 (dsRNA, poly I:C and poly A:U), TLR4 (ANA380, isatoribine, LPS and mimetics such as MPL), TLR7 (oligonucleotides, ssRNA), TLR9 (oligonucleotides such as CpGs), a number of examples of which are described in Akira and Takeda ((2004) Nature Reviews 4: 499), and antibodies that block inhibitory receptors on NK cells (for example that inhibit KIR2DL1 and KIR2DL2/3 activity) or act as agonists at NK cell activatory receptors (for example antibodies that crosslink NCR receptors NKp30, NKp44 or NK046).

Article Title: Monoclonal antibodies against NKG2A
Article Snippet: Examples of immunomodulating compounds include but are not limited to ligands of NOD and PKR receptors, agonists of TLRs (Toll-like receptors), such as agonists of TLR3 (dsRNA, poly I:C and poly A:U), TLR4 (ANA380, isatoribine, LPS and mimetics such as MPL), TLR7 (oligonucleotides, ssRNA), TLR9 (oligonucleotides such as CpGs), a number of examples of which are described in Akira and Takeda ((2004) Nature Reviews 4: 499), and antibodies that block inhibitory receptors on NK cells (for example that inhibit KIR2DL1 and KIR2DL2/3 activity) or act as agonists at NK cell activatory receptors (for example antibodies that crosslink NCR receptors NKp30, NKp44 or NKp46).



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OKF6/Tert-1 cells were treated with 1 μg/ml <t>poly(I:C)</t> for up to six hours and measured for changes in type I interferon expression by RT-qPCR. Bar graphs and error bars represent the means and standard errors of measurement (SEM) of three independent experiments, each with three biological replicates per condition. *p < 0.05, **p < 0.005, and ***p < 0.0005 compared to 0h, using a two-tailed, unpaired Student’s t-test. All data analysis was performed using GraphPad Prism version 8.2.0 for Windows, GraphPad Software, La Jolla California USA, www.graphpad.com.
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OKF6/Tert-1 cells were treated with 1 μg/ml poly(I:C) for up to six hours and measured for changes in type I interferon expression by RT-qPCR. Bar graphs and error bars represent the means and standard errors of measurement (SEM) of three independent experiments, each with three biological replicates per condition. *p < 0.05, **p < 0.005, and ***p < 0.0005 compared to 0h, using a two-tailed, unpaired Student’s t-test. All data analysis was performed using GraphPad Prism version 8.2.0 for Windows, GraphPad Software, La Jolla California USA, www.graphpad.com.

Journal: Molecular oral microbiology

Article Title: Type I Interferon and Interferon-stimulated Gene Expression in Oral Epithelial Cells

doi: 10.1111/omi.12270

Figure Lengend Snippet: OKF6/Tert-1 cells were treated with 1 μg/ml poly(I:C) for up to six hours and measured for changes in type I interferon expression by RT-qPCR. Bar graphs and error bars represent the means and standard errors of measurement (SEM) of three independent experiments, each with three biological replicates per condition. *p < 0.05, **p < 0.005, and ***p < 0.0005 compared to 0h, using a two-tailed, unpaired Student’s t-test. All data analysis was performed using GraphPad Prism version 8.2.0 for Windows, GraphPad Software, La Jolla California USA, www.graphpad.com.

Article Snippet: OKF6/Tert-1 cells were treated with either 1 μg/ml double-stranded RNA mimetic poly(I:C) (Invivogen, tlrl-picw) in cell culture media for up to six hours.

Techniques: Expressing, Quantitative RT-PCR, Two Tailed Test, Software

OKF6/Tert-1 cells were treated with 1 μg/ml poly(I:C) for up to six hours and measured for changes in interferon-stimulated gene (ISG) expression by RT-qPCR. Measured genes were divided into each ISG basal expression group, according to Table 2: Low (A), Medium (B), and High (C). Bar graphs and error bars represent the means and standard errors of measurement (SEM) of three independent experiments, each with three biological replicates per condition. *p < 0.05, **p < 0.005, and ***p < 0.0005 compared to 0h, using a two-tailed, unpaired Student’s t-test.

Journal: Molecular oral microbiology

Article Title: Type I Interferon and Interferon-stimulated Gene Expression in Oral Epithelial Cells

doi: 10.1111/omi.12270

Figure Lengend Snippet: OKF6/Tert-1 cells were treated with 1 μg/ml poly(I:C) for up to six hours and measured for changes in interferon-stimulated gene (ISG) expression by RT-qPCR. Measured genes were divided into each ISG basal expression group, according to Table 2: Low (A), Medium (B), and High (C). Bar graphs and error bars represent the means and standard errors of measurement (SEM) of three independent experiments, each with three biological replicates per condition. *p < 0.05, **p < 0.005, and ***p < 0.0005 compared to 0h, using a two-tailed, unpaired Student’s t-test.

Article Snippet: OKF6/Tert-1 cells were treated with either 1 μg/ml double-stranded RNA mimetic poly(I:C) (Invivogen, tlrl-picw) in cell culture media for up to six hours.

Techniques: Expressing, Quantitative RT-PCR, Two Tailed Test