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Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), <t>pirfenidone</t> (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Pirfenidone, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), <t>pirfenidone</t> (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), <t>pirfenidone</t> (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), <t>pirfenidone</t> (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), <t>pirfenidone</t> (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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sc 281692 pirfenidone medchemexpress cat  (MedChemExpress)
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MedChemExpress sc 281692 pirfenidone medchemexpress cat
Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), <t>pirfenidone</t> (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), pirfenidone (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Journal: Frontiers in Pharmacology

Article Title: GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease

doi: 10.3389/fphar.2025.1671132

Figure Lengend Snippet: Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), pirfenidone (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Article Snippet: Nintedanib and pirfenidone were both purchased from MedChemExpress (HY-50904 and HY-B0673).

Techniques: Marker, Gene Expression