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ER stress inducers promote keretinocyte differentiation partially through UPR activation. Primary mouse keretinocyte were treated with UPR pathway inhibitors: 4μ8C or Kira 6 (IRE1/XPB1 inhibitors), <t>GSK2606414</t> or GSK2656157 (PERK inhibitors) with or without TM (a and b) or BFA (c and d) for 48 h, followed by detection of ER stress and differentiation markers. Data are mean ± SEM. ns: not significant, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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ER stress inducers promote keretinocyte differentiation partially through UPR activation. Primary mouse keretinocyte were treated with UPR pathway inhibitors: 4μ8C or Kira 6 (IRE1/XPB1 inhibitors), <t>GSK2606414</t> or GSK2656157 (PERK inhibitors) with or without TM (a and b) or BFA (c and d) for 48 h, followed by detection of ER stress and differentiation markers. Data are mean ± SEM. ns: not significant, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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ER stress inducers promote keretinocyte differentiation partially through UPR activation. Primary mouse keretinocyte were treated with UPR pathway inhibitors: 4μ8C or Kira 6 (IRE1/XPB1 inhibitors), <t>GSK2606414</t> or GSK2656157 (PERK inhibitors) with or without TM (a and b) or BFA (c and d) for 48 h, followed by detection of ER stress and differentiation markers. Data are mean ± SEM. ns: not significant, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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Image Search Results


ER stress inducers promote keretinocyte differentiation partially through UPR activation. Primary mouse keretinocyte were treated with UPR pathway inhibitors: 4μ8C or Kira 6 (IRE1/XPB1 inhibitors), GSK2606414 or GSK2656157 (PERK inhibitors) with or without TM (a and b) or BFA (c and d) for 48 h, followed by detection of ER stress and differentiation markers. Data are mean ± SEM. ns: not significant, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

Journal: Cell Stress & Chaperones

Article Title: Activation of unfolded protein response pathways promotes keratinocyte differentiation and ameliorates psoriasis phenotypes

doi: 10.1016/j.cstres.2026.100163

Figure Lengend Snippet: ER stress inducers promote keretinocyte differentiation partially through UPR activation. Primary mouse keretinocyte were treated with UPR pathway inhibitors: 4μ8C or Kira 6 (IRE1/XPB1 inhibitors), GSK2606414 or GSK2656157 (PERK inhibitors) with or without TM (a and b) or BFA (c and d) for 48 h, followed by detection of ER stress and differentiation markers. Data are mean ± SEM. ns: not significant, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

Article Snippet: The IRE1α inhibitor 4μ8C (Selleck, S7272) and Kira6 (Selleck, S8658), as well as the PERK inhibitors GSK2606414 (Selleck, S7307) or GSK2656157 (Selleck, S7033), were dissolved in DMSO and used at a final concentration of 4μ8C 1 mM, Kira6 5 μM, GSK2606414 140 μM, GSK2656157 3 μM.

Techniques: Activation Assay

This diagram integrates genes that maintain cytoskeletal architecture, vesicle sorting, autophagy-lysosomal function, and protein quality control. MAPT regulates microtubule accessibility for transport motors. PLEKHM1 links Rab7-positive autophagosomes to dynein and the HOPS complex, enabling autophagosome–lysosome fusion. STX6 mediates endosome–Golgi trafficking and participates in tau secretion. APOE influences endosomal recycling and lysosomal degradation. EIF2AK3 (PERK) mediates the unfolded protein response (UPR), limiting ER stress and reducing misfolded protein accumulation. TRIM11 , an E3 ligase, promotes clearance of misfolded tau through ubiquitin-proteasomal pathways. MOBP , CNTN2/NFASC , and KANSL1 support cytoskeleton integrity, affecting vesicle trafficking. SLCO1A2 and C4A play peripheral modulatory roles in membrane transport and complement signaling.

Journal: Frontiers in Aging

Article Title: Risk genes in progressive supranuclear palsy (PSP) affect integrity and function of microtubules

doi: 10.3389/fragi.2026.1769377

Figure Lengend Snippet: This diagram integrates genes that maintain cytoskeletal architecture, vesicle sorting, autophagy-lysosomal function, and protein quality control. MAPT regulates microtubule accessibility for transport motors. PLEKHM1 links Rab7-positive autophagosomes to dynein and the HOPS complex, enabling autophagosome–lysosome fusion. STX6 mediates endosome–Golgi trafficking and participates in tau secretion. APOE influences endosomal recycling and lysosomal degradation. EIF2AK3 (PERK) mediates the unfolded protein response (UPR), limiting ER stress and reducing misfolded protein accumulation. TRIM11 , an E3 ligase, promotes clearance of misfolded tau through ubiquitin-proteasomal pathways. MOBP , CNTN2/NFASC , and KANSL1 support cytoskeleton integrity, affecting vesicle trafficking. SLCO1A2 and C4A play peripheral modulatory roles in membrane transport and complement signaling.

Article Snippet: EIF2AK3 (PERK) , ER stress and proteostasis regulation , PERK modulates protein synthesis affecting axonal maintenance and MT-associated proteins , UPR activation alters tubulin/MAP synthesis and axonal protein supply; chronic PERK activation linked to MN degeneration , .

Techniques: Control, Ubiquitin Proteomics, Membrane