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pai 039  (Pfizer Inc)

 
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    Pfizer Inc pai 039
    Pai 039, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pai+039/039+pai/pm42030999-158-4-7
    Average 86 stars, based on 1 article reviews
    pai 039 - by Bioz Stars, 2026-11
    86/100 stars

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    Article Title: Plasminogen Activator Inhibitor-1 Controls Mitochondrial Oxidative Stress in Vascular Smooth Muscle Cells and Coronary Arteries.
    Article Snippet: No Abstract Corresponding Author: Dr. William P Fay, University of Missouri, Medicine, One Hospital Drive, 65211-1300 Columbia, United States, fayw@missouri.edu Affiliations: Alex Schoenherr, University of Missouri, Medicine, Columbia, United States Yan Ji, University of Missouri, Medicine, Columbia, United States Hekmat Khoukaz, University of Missouri, Medicine, Columbia, United States [...] William P Fay, Harry S Truman Memorial Veterans‘ Hospital, Research Service, Columbia, United States Submission Date: 2026-03-12 Accepted Date: 2026-04-09 Accepted Manuscript online: D ow nl oa de d by : U S P U ni ve rs id ad e de S ão P au lo .. C op yr ig ht ed m at er ia l. 2026-04-24 Plasminogen Activator Inhibitor-1 Controls Mitochondrial Oxidative Stress in Vascular Smooth Muscle Cells and Coronary Arteries Alex Schoenherr, Yan Ji, Hekmat B. Khoukaz, Zhen Lyu, Owen Walls, Mojgan Golzy, Trupti Joshi, Dunpeng Cai, Shi-You Chen, Michael A. Hill, Luis A. MartinezLemus, Scott Zawieja, Charles E. Norton, William P. Fay From the Department of Medicine, Department of Medical Pharmacology & Physiology, Department of Biomedical Informatics, Biostatistics and Medical Epidemiology, and the Department of Surgery, School of Medicine, and from the Department of Electrical Engineering & Computer Science, College of Engineering, the Dalton Cardiovascular Research Center, University of Missouri, and the Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.. *Alex Schoenherr and Yan Ji contributed equally to this work Address for correspondence: William P. Fay, MD, Department of Medicine, Division of Cardiovascular Medicine, University of Missouri, 5 Hospital Drive, CE345, Columbia, Missouri 65212.



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    EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 <t>+</t> <t>PAI‐039,</t> H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.
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    EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 <t>+</t> <t>PAI‐039,</t> H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.
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    EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + PAI‐039, H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.

    Journal: The FASEB Journal

    Article Title: Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF ‐β/Smad2/3 Signaling in Mice

    doi: 10.1096/fj.202403133RR

    Figure Lengend Snippet: EGCG decreased H 2 O 2 ‐induced extracellular matrix protein turnover‐related targeted proteins expressions in MAVSMCs treated with PAI‐1 inhibitor and plPAI‐1. (A, B) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + PAI‐039, H 2 O 2 + PAI‐039 + EGCG groups ( n = 3/group). (C, D) Representative Western Blotting images and quantitative data for the levels of collagen I, collagen III, TGF‐β, and p‐Smad2/3 proteins in Cont, H 2 O 2 , H 2 O 2 + pl‐PAI‐1, H 2 O 2 + EGCG groups ( n = 3/group). Data are mean ± SEM. Statistical significance was assessed by 1‐way ANOVA for B and D. NC indicates negative control. PAI‐039 indicates PAI‐1 inhibitor. pl‐PAI‐1 indicates PAI‐1 overexpression.

    Article Snippet: Tiplaxtinin (PAI‐039, APExBIO, Houston, USA) known as a PAI‐1 inhibitor was applied to VSMC experiments at indicated concentration (10 μM).

    Techniques: Western Blot, Negative Control, Over Expression