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two-tailed, nonparametric spearman correlation test  (GraphPad Software Inc)


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    GraphPad Software Inc two-tailed, nonparametric spearman correlation test
    Two Tailed, Nonparametric Spearman Correlation Test, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nonparametric+correlation+spearman+test/nonparametric+statistics+graphpad+prism/pm40399675-700-15-20
    Average 90 stars, based on 1 article reviews
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    Article Title: The length of the Staphylococcus aureus protein A polymorphic region regulates inflammation: impact on acute and chronic infection.
    Article Snippet: GraphPad Prism software was used. .. The spa typing data from clinical isolates were analyzed using the Fisher exact test and the nonparametric correlation Spearman test from GraphPad Prism software. ..



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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the <t>nonparametric</t> Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.
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    Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the nonparametric Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.

    Journal: Biomaterials Research

    Article Title: Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo

    doi: 10.34133/bmr.0112

    Figure Lengend Snippet: Repeat injection of Comirnaty marginally induced PEG-specific antibodies. The concentration of anti-PEG antibodies in mouse plasma was assessed on day 28 after each vaccination. (A) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (B) A comparison of the concentrations of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 1 (◯) ( n = 10). (C) A comparison of the concentrations of anti-PEG IgG before vaccination and after 3 doses of Comirnaty in group 2 (△) ( n = 10). (D) A comparison of the concentration of anti-PEG IgM before vaccination and after 3 doses of Comirnaty in group 2 (△) (prevax and 1st dose, n = 10; 2nd dose and 3rd dose, n = 9). (E) Cross-comparison of the fold-change (log 10 ) of anti-PEG IgG and IgM (F) among the 3 cohorts: naïve groups (prevax/3rd dose, n = 10), group 1 (prevax/3rd dose, n = 10), and group 2 (prevax/3rd dose, n = 9). (E and F) Data were derived by the nonparametric Kruskal–Wallis test with Dunn’s multiple comparisons test ( n = 10 in naïve group and group 1; n = 9 in group 2). Prevax, prevaccination; 3rd dose, 3rd dose of Comirnaty vaccination.

    Article Snippet: Correlation analysis in Fig. A to C were performed using nonparametric Spearman correlation tests, also using GraphPad Prism 8.0.

    Techniques: Injection, Concentration Assay, Clinical Proteomics, Comparison, Derivative Assay