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mtor pathway  (MedChemExpress)


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    MedChemExpress mtor pathway
    YTHDF3 regulates the glycolysis level of breast cancer through the <t>mTOR–HIF1α–LDHA</t> axis. (A) Relative mRNA expression of HIF1α in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (B) the correlation between YTHDF3 and HIF1α was predicted using the GEPIA website; (C) expression of key proteins in the mTOR–HIF1α–LDHA axis in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (D) after <t>adding</t> <t>activator</t> MHY1445, the growth ability of cancer cells in shNC and shYTHDF3 groups was detected by CCK‐8 assay; (E) the lactate level of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485; and (F) expression of proteins of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485.
    Mtor Pathway, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 262 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mtor+pathway/pmc13111412-67-4-10?v=MedChemExpress
    Average 97 stars, based on 262 article reviews
    mtor pathway - by Bioz Stars, 2026-08
    97/100 stars

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    1) Product Images from "YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR – HIF1α – LHDA Axis"

    Article Title: YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR – HIF1α – LHDA Axis

    Journal: Journal of Cellular and Molecular Medicine

    doi: 10.1111/jcmm.71105

    YTHDF3 regulates the glycolysis level of breast cancer through the mTOR–HIF1α–LDHA axis. (A) Relative mRNA expression of HIF1α in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (B) the correlation between YTHDF3 and HIF1α was predicted using the GEPIA website; (C) expression of key proteins in the mTOR–HIF1α–LDHA axis in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (D) after adding activator MHY1445, the growth ability of cancer cells in shNC and shYTHDF3 groups was detected by CCK‐8 assay; (E) the lactate level of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485; and (F) expression of proteins of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485.
    Figure Legend Snippet: YTHDF3 regulates the glycolysis level of breast cancer through the mTOR–HIF1α–LDHA axis. (A) Relative mRNA expression of HIF1α in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (B) the correlation between YTHDF3 and HIF1α was predicted using the GEPIA website; (C) expression of key proteins in the mTOR–HIF1α–LDHA axis in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (D) after adding activator MHY1445, the growth ability of cancer cells in shNC and shYTHDF3 groups was detected by CCK‐8 assay; (E) the lactate level of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485; and (F) expression of proteins of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485.

    Techniques Used: Expressing, CCK-8 Assay



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    Image Search Results


    YTHDF3 regulates the glycolysis level of breast cancer through the mTOR–HIF1α–LDHA axis. (A) Relative mRNA expression of HIF1α in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (B) the correlation between YTHDF3 and HIF1α was predicted using the GEPIA website; (C) expression of key proteins in the mTOR–HIF1α–LDHA axis in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (D) after adding activator MHY1445, the growth ability of cancer cells in shNC and shYTHDF3 groups was detected by CCK‐8 assay; (E) the lactate level of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485; and (F) expression of proteins of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485.

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR – HIF1α – LHDA Axis

    doi: 10.1111/jcmm.71105

    Figure Lengend Snippet: YTHDF3 regulates the glycolysis level of breast cancer through the mTOR–HIF1α–LDHA axis. (A) Relative mRNA expression of HIF1α in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (B) the correlation between YTHDF3 and HIF1α was predicted using the GEPIA website; (C) expression of key proteins in the mTOR–HIF1α–LDHA axis in shNC and shYTHDF3 groups in MDA‐MB‐231 and MCF‐7 cells; (D) after adding activator MHY1445, the growth ability of cancer cells in shNC and shYTHDF3 groups was detected by CCK‐8 assay; (E) the lactate level of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485; and (F) expression of proteins of cancer cells in shNC and shYTHDF3 groups treated with activator MHY1485.

    Article Snippet: The activator of the mTOR pathway, MHY1485, was obtained from MedChemExpress (Shanghai, China) at a concentration of 10 mM.

    Techniques: Expressing, CCK-8 Assay

    Effects of Gln and RAPA on the mTOR/Notch1 axis and MUC2 expression in HT-29 cells. (A) The expression of mTOR, p-mTOR, Notch1, and GAPDH. (B) Immunofluorescence analysis of MUC2 in HT-29 cells (800×). Data are presented as mean ± SD (n = 3). One-way ANOVA was carried out followed by Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Journal: Frontiers in Oncology

    Article Title: Glutamine alleviates radiation-induced intestinal injury in rats via the mTOR/Notch1 axis

    doi: 10.3389/fonc.2026.1735401

    Figure Lengend Snippet: Effects of Gln and RAPA on the mTOR/Notch1 axis and MUC2 expression in HT-29 cells. (A) The expression of mTOR, p-mTOR, Notch1, and GAPDH. (B) Immunofluorescence analysis of MUC2 in HT-29 cells (800×). Data are presented as mean ± SD (n = 3). One-way ANOVA was carried out followed by Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Article Snippet: To investigate the role of mTOR/notch1 pathway on Gln radio-resistance effects in colon, HT-29 cells were treated with the 10 μmol/L Jagged-1 (MCE, USA) , which activates the Notch1 receptor.

    Techniques: Expressing, Immunofluorescence

    Effects of Gln and Jagged-1 on the mTOR/Notch1 axis and MUC2 expression in HT-29 cells. (A) The expression of mTOR, p-mTOR, Notch1, and GAPDH. (B) Immunofluorescence analysis of MUC2 in HT-29 cells (800×). Data are presented as mean ± SD (n = 3). One-way ANOVA was carried out followed by Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Journal: Frontiers in Oncology

    Article Title: Glutamine alleviates radiation-induced intestinal injury in rats via the mTOR/Notch1 axis

    doi: 10.3389/fonc.2026.1735401

    Figure Lengend Snippet: Effects of Gln and Jagged-1 on the mTOR/Notch1 axis and MUC2 expression in HT-29 cells. (A) The expression of mTOR, p-mTOR, Notch1, and GAPDH. (B) Immunofluorescence analysis of MUC2 in HT-29 cells (800×). Data are presented as mean ± SD (n = 3). One-way ANOVA was carried out followed by Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Article Snippet: To investigate the role of mTOR/notch1 pathway on Gln radio-resistance effects in colon, HT-29 cells were treated with the 10 μmol/L Jagged-1 (MCE, USA) , which activates the Notch1 receptor.

    Techniques: Expressing, Immunofluorescence

    Regulatory effect of Notch/mTOR on the developmental process of PFs in zebrafish. ( A ) qRT-PCR to detect the expression of notch2 , akt2 , and mtor genes in different types of PFs in zebrafish. ( B ) Immunohistochemistry (IHC) to detect the Notch and mTOR proteins localization in the ovary and expression of different types of PFs of zebrafish; scale bar, 50 μM; ( C , F , I ) Histological observation of the ovary in the treated group with IMR-1, P529, and dietary amino acid supplementation; scale bar, 100 μM. ( D ) The hey1 , hey2 , hes , mtor , and s6k1 mRNA levels in the ovary tissues of IMR-1-treated groups. ( E ) The Notch, mTOR, and p-mTOR protein levels were expressed in the ovarian tissues of IMR-1-treated groups. ( G ) The s6k1 and notch mRNA levels were expressed in the ovarian tissues of the P529-treated groups. ( H ) The mTOR, p-mTOR, S6K1, and p-S6K1 protein levels of expression in the ovarian tissues of the P529-treated groups. ( J ) The mtor , s6k1 , and notch mRNA levels of expression in the ovarian tissues of the amino acid addition group. ( K ) The mTOR, p-mTOR, S6K1, P-S6K1, and Notch protein levels were expressed in the ovarian tissues of the amino acid addition group. “*”: p < 0.05; “**”: p < 0.01; “***”: p < 0.001 ; “****”: p < 0.0001. (means ± SD of relative expression; n = 3 for each group).

    Journal: Biology

    Article Title: Primary Follicle Paces Fish Ovarian Maturation Developmental Progression via the Enhancement of Notch and mTOR

    doi: 10.3390/biology14121752

    Figure Lengend Snippet: Regulatory effect of Notch/mTOR on the developmental process of PFs in zebrafish. ( A ) qRT-PCR to detect the expression of notch2 , akt2 , and mtor genes in different types of PFs in zebrafish. ( B ) Immunohistochemistry (IHC) to detect the Notch and mTOR proteins localization in the ovary and expression of different types of PFs of zebrafish; scale bar, 50 μM; ( C , F , I ) Histological observation of the ovary in the treated group with IMR-1, P529, and dietary amino acid supplementation; scale bar, 100 μM. ( D ) The hey1 , hey2 , hes , mtor , and s6k1 mRNA levels in the ovary tissues of IMR-1-treated groups. ( E ) The Notch, mTOR, and p-mTOR protein levels were expressed in the ovarian tissues of IMR-1-treated groups. ( G ) The s6k1 and notch mRNA levels were expressed in the ovarian tissues of the P529-treated groups. ( H ) The mTOR, p-mTOR, S6K1, and p-S6K1 protein levels of expression in the ovarian tissues of the P529-treated groups. ( J ) The mtor , s6k1 , and notch mRNA levels of expression in the ovarian tissues of the amino acid addition group. ( K ) The mTOR, p-mTOR, S6K1, P-S6K1, and Notch protein levels were expressed in the ovarian tissues of the amino acid addition group. “*”: p < 0.05; “**”: p < 0.01; “***”: p < 0.001 ; “****”: p < 0.0001. (means ± SD of relative expression; n = 3 for each group).

    Article Snippet: The Notch signaling pathway inhibitor Inhibitor of Mastermind Recruitment-1 (IMR-1) [ , ] (Selleck, S8280, Selleck Chemicals, Houston, TX, USA) and the mTOR signaling pathway inhibitor Palomid 529 (P529) [ , ] (Selleck, S2238) were separately dissolved in DMSO to prepare their 10 mM stock solutions.

    Techniques: Quantitative RT-PCR, Expressing, Immunohistochemistry