msa 2 (MedChemExpress)

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MedChemExpress msa 2
Msa 2, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 54 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/msa+2/MSA-2/10__1007_slash_s13402___026___01300___8-62-24-39
Average 95 stars, based on 54 article reviews

msa 2 - by Bioz Stars, 2026-11

95/100 stars

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Expressing:

Article Title: Synergistic reprogramming of the tumor immune microenvironment by Senecavirus A and STING agonist.
Article Snippet: Stimulator of interferon genes (STING) agonists have shown promise in cancer immunotherapy by enhancing type I interferon (IFNI) signaling.. However, the antiviral effects of IFN-I can suppress viral replication, limiting their combination with oncolytic viruses.. This study demonstrates that combining a naturally isolated Senecavirus A (SVA) strain with the STING agonist MSA-2 supports synergistic IFN-I activation across multiple tumor models.

Negative Control:

other:

Article Title: BRD4 is a key regulator of STING expression
Article Snippet: Compounds: JQ1 (HY-13030), dBET6 (HY-112588), CQ (Chloroquine; HY-17589 A), MG132 (HY-13259), AZD5153 (HY-100653), decitabine (HY-A0004), CMA (Cridanimod; HY-W011890), DMXAA (Vadimezan; HY-10964), diABZI (HY-112921 A), MSA-2 (HY-136927), I-BET151 (HY-13235), I-BET726 (HY-13960), olaparib (HY-10162), and talazoparib (BMN673; HY-16106) were purchased from MCE (New Jersey, USA).

Article Title: Constant cGAS activation blunts STING signaling in DU145 prostate cancer cell line.
Article Snippet: STING is further transported to recycling endosomes and then to lysosomes, Address correspondence to: Kozo Tanaka, MD, PhD, Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan Tel: +81-22-717-8491, Fax: +81-22-717-8491 E-mail: kozo.tanaka.d2@tohoku.ac.jp body (D83B9) (CST, 4302) for WB 1 : 200; anti-phospho-IRF3 rabbit monoclonal antibody (4D4G) (Cell Signaling Technology, 4947) for WB 1 : 250; anti-α-tubulin mouse monoclonal antibody (B-5-1-2) (Merck, T5168) for WB 1 : 1000; anti-Human CD107a (LAMP1) mouse monoclonal antibody (H4A3) (BD Biosciences, 555798) for IF 1 : 1000; Goat Anti-Rabbit IgG (H + L) Mouse/Human adsHRP (Southern Biotech, 4050-05) for WB 1 : 10000; Goat Anti-Mouse IgG (H + L) Human ads-HRP (Southern Biotech, 1031-05) for WB 1 : 10000; Alexa-conjugated secondary antibodies (Thermo Fisher Scientific, A11034, A32728) for IF 1 : 1000.

Synthesized:

Article Title: Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16-CXCR6 signaling for potent antitumor response.
Article Snippet: Band intensities were quantified using ImageJ software. .. The linker-payload complex was synthesized using Fmoc-Val-Cit-PAB (Y-PE-4775), Mal-PEG4-NHS (Y-PE-2017) from New Research Biosciences, and MSA-2 (HY-136927, MCE) (Supplementary Fig. 21). .. For ISAC synthesis, YM101 (20mg) was reacted with Traut’s reagent (20 equivalents) (BD75935, Bidepharm) in PBS to introduce sulfhydryl groups, resulting in a sulfhydryl-functionalized antibody.

Article Title: Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response
Article Snippet: Band intensities were quantified using ImageJ software. .. The linker-payload complex was synthesized using Fmoc-Val-Cit-PAB (Y-PE-4775), Mal-PEG4-NHS (Y-PE-2017) from New Research Biosciences, and MSA-2 (HY-136927, MCE) (Supplementary Fig. ). .. For ISAC synthesis, YM101 (20 mg) was reacted with Traut’s reagent (20 equivalents) (BD75935, Bidepharm) in PBS to introduce sulfhydryl groups, resulting in a sulfhydryl-functionalized antibody.

Protein-Protein interactions:

Article Title: Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth.
Article Snippet: The following antibodies were used for immunoblotting: GFP (Cell Signaling Technology [Danvers, MA, USA], #2956S, 1:1000), IRF3 (Cell Signaling Technology #4302S, 1:1000), phospho-TBK1 (Cell Signaling Technology #5483S, 1:1000), TBK1 (Cell Signaling Technology #71543SF, 1:1000), phospho-STING (Cell Signaling Technology #72971S, 1:1000), STING (Cell Signaling Technology #13647S, 1:1000), Cleaved caspase 3 (Cell Signaling Technology #9661S, 1:1000), β-actin (Sigma-Aldrich [St. Louis, MI, USA], #A5441, 1:10,000), VPS4A (Sigma-Aldrich #SAB4200215, 1:1000), VPS4B (Santa Cruz Biotechnology [Dallas, TX, USA], #sc-377162, 1:200), cGAS (Cell Signaling Technology #31659S, 1:1000), p62/SQSTM1 (PROGEN Biotechnik [Heidelberg, Germany], #GP62-C, 1:1000), ATF-3 (Cell Signaling Technology #18665S, 1:1000), and LC3B (Novus Biologicals [Centennial, CO, USA] #NB100-2220, 1:5000). .. The following inhibitors were used to dissect innate immune signaling pathways: BMS-345541 (Sigma-Aldrich #B9935-5MG), 5Z-7-oxozeaenol (MedChemExpress [Monmouth Junction, NJ, USA], #HY-12686), GSK8612 (MedChemExpress #HY-111941), C-176 (MedChemExpress #HY-112906), NBP2-31226 (Novus Biologicals #NBP2-31226), RIG012 (MedChemExpress #HY-147124), and MSA-2 (MedChemExpress #HY-136927). .. RNA-seq and gene enrichment analysis Total RNA samples were extracted using RNeasy Plus Mini Kit (Qiagen [Germantown, MD, USA], #74136) and mRNA-seq was performed by Novogene Corporation, Inc (Beijing, China).

Article Title: Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth
Article Snippet: The following antibodies were used for immunoblotting: GFP (Cell Signaling Technology [Danvers, MA, USA], #2956S, 1:1000), IRF3 (Cell Signaling Technology #4302S, 1:1000), phospho-TBK1 (Cell Signaling Technology #5483S, 1:1000), TBK1 (Cell Signaling Technology #71543SF, 1:1000), phospho-STING (Cell Signaling Technology #72971S, 1:1000), STING (Cell Signaling Technology #13647S, 1:1000), Cleaved caspase 3 (Cell Signaling Technology #9661S, 1:1000), β-actin (Sigma-Aldrich [St. Louis, MI, USA], #A5441, 1:10,000), VPS4A (Sigma-Aldrich #SAB4200215, 1:1000), VPS4B (Santa Cruz Biotechnology [Dallas, TX, USA], #sc-377162, 1:200), cGAS (Cell Signaling Technology #31659S, 1:1000), p62/SQSTM1 (PROGEN Biotechnik [Heidelberg, Germany], #GP62-C, 1:1000), ATF-3 (Cell Signaling Technology #18665S, 1:1000), and LC3B (Novus Biologicals [Centennial, CO, USA] #NB100-2220, 1:5000). .. The following inhibitors were used to dissect innate immune signaling pathways: BMS-345541 (Sigma-Aldrich #B9935-5MG), 5Z-7-oxozeaenol (MedChemExpress [Monmouth Junction, NJ, USA], #HY-12686), GSK8612 (MedChemExpress #HY-111941), C-176 (MedChemExpress #HY-112906), NBP2-31226 (Novus Biologicals #NBP2-31226), RIG012 (MedChemExpress #HY-147124), and MSA-2 (MedChemExpress #HY-136927). .. Total RNA samples were extracted using RNeasy Plus Mini Kit (Qiagen [Germantown, MD, USA], #74136) and mRNA-seq was performed by Novogene Corporation, Inc (Beijing, China).

In Vitro:

Article Title: Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16-CXCR6 signaling for potent antitumor response.
Article Snippet: .. For in vitro treatments, cells were stimulated with MSA-2 (5μg/ mL, HY-136927, MCE), TGF-β1 (20 ng/mL, Z03411, GenScript), antiIFNAR1 (100μg/mL, HY-P990439, MCE), anti-TGF-β (100μg/mL, YZY Biopharma), anti-PD-L1 (100μg/mL, YZY Biopharma), or N-acetylcysteine (2mM, HY-B0215, MCE), alone or in combination as indicated. .. During transfection, si-STAT1 (Tsingke), si-HDAC4 (Tsingke), and Hieff Trans® in vitro siRNA/miRNA Transfection Reagent (40806ES03, Yeasen) were used according to the manufacturer’s protocol (Table S4).

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