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il 12  (Proteintech)


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    Proteintech il 12
    Il 12, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/il 12/product/Proteintech
    Average 93 stars, based on 18 article reviews
    il 12 - by Bioz Stars, 2026-03
    93/100 stars

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    Image Search Results


    Administration of IL-12 beta protein increases seizure susceptibility. (A) Seizure susceptibility measured by 6-Hz seizure threshold test ( n = 12 mice/group). (B) Seizure score within 30 min after picrotoxin administration ( n = 6 mice/group). (C) A representative diagram illustrating EEG, EMG, baseline, and seizure patterns after pilocarpine administration. (D) A time-frequency spectrogram of EEG corresponding to the EEG in (C) ( n = 10 mice/group). (E) Latency to SE after pilocarpine administration. (F) Survival probability within 60 min post pilocarpine administration ( n = 10 mice/group). * p < 0.05, ** p < 0.01 by Student’s t test ( A and E ), generalized linear models with Bonferroni test (B) , Kaplan–Meier analysis with Log Rank (Mantel-Cox) test (F) . Values are means ± SD ( A and E ), medians (IQR) (B) , rate (F) .

    Journal: Frontiers in Neurology

    Article Title: Elevated interleukin-12B is associated with increased seizure susceptibility: insights from two-sample Mendelian randomization and in vivo experiment

    doi: 10.3389/fneur.2025.1706857

    Figure Lengend Snippet: Administration of IL-12 beta protein increases seizure susceptibility. (A) Seizure susceptibility measured by 6-Hz seizure threshold test ( n = 12 mice/group). (B) Seizure score within 30 min after picrotoxin administration ( n = 6 mice/group). (C) A representative diagram illustrating EEG, EMG, baseline, and seizure patterns after pilocarpine administration. (D) A time-frequency spectrogram of EEG corresponding to the EEG in (C) ( n = 10 mice/group). (E) Latency to SE after pilocarpine administration. (F) Survival probability within 60 min post pilocarpine administration ( n = 10 mice/group). * p < 0.05, ** p < 0.01 by Student’s t test ( A and E ), generalized linear models with Bonferroni test (B) , Kaplan–Meier analysis with Log Rank (Mantel-Cox) test (F) . Values are means ± SD ( A and E ), medians (IQR) (B) , rate (F) .

    Article Snippet: Mice were randomly assigned into two groups. (1) Control group: mice received an intraperitoneal (i.p.) injected of saline (10 mL/kg); (2) IL-12B group: mice were administered an injection of IL-12 beta protein (mouse, HEK293, His; 1 μg/mouse/day, i.p., MedChemExpress, USA) for three consecutive days.

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