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modifier subunit  (Proteintech)


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    Structured Review

    Proteintech modifier subunit
    Modifier Subunit, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 175 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/modifier+subunit+gclm/GCLM+Antibody/pmc13001054-77-12-72
    Average 94 stars, based on 175 article reviews
    modifier subunit - by Bioz Stars, 2026-10
    94/100 stars

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    Related Articles

    Western Blot:

    Article Title: 3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.
    Article Snippet: Oxidative stress is implicated in the pathogenesis of various neurodegenerative diseases including Parkinson0s disease (PD).. 3,4‐ Dihydroxybenzalacetone (DBL) is a small catechol‐containing compound isolated from Chaga (Inonotus obliquus [persoon] Pilat), and has been reported to have beneficial bioactivities, including antioxidative, anti‐inflammatory, and anti‐tumorigenic activities, with a relatively low toxicity to normal cells.. We, therefore, investigated the neuroprotective activity of DBL against the PD‐related neurotoxin 6‐hydroxydopamine (6‐OHDA).



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    AST attenuated AFB1-induced oxidative stress damage in the liver through the Nrf2 pathway. A Immunoblotting analysis of the protein expression of Keap1, Nrf2, <t>HO-1,</t> <t>NQO1,</t> GCLC and <t>GCLM.</t> The images were merely cropped from the original exposure picture to remove the meaningless parts. B - G The relative levels of the target proteins are shown as histograms representing density readings of the gel bands, and the ratios were calculated relative to the β-actin control. Different capital letters represent P < 0.05
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    Effect of Fx on Nrf2 and ferroptosis signaling pathways in the liver of CCl 4 ‐induced mice. (A) Protein expression of hepatic Nrf2, heme oxygenase‐1 (HO‐1), nicotinamide quinone oxidoreductase 1 (NQO1), and glutamate‐cysteine ligase modifier subunit <t>(GCLM)</t> expression. (B) Protein expression of hepatic GPX4, solute carrier family 7 member 11 (SLC7A11), transferrin receptor 1 (TFR1), and ferritin light chain (FTL). Data are expressed as the mean ± SD ( n = 3). * p < 0.05, ** p < 0.01 and *** p < 0.001 versus CCl 4 group. ### p < 0.001 between the L‐Fx and H‐Fx groups.
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    Effect of Fx on Nrf2 and ferroptosis signaling pathways in the liver of CCl 4 ‐induced mice. (A) Protein expression of hepatic Nrf2, heme oxygenase‐1 (HO‐1), nicotinamide quinone oxidoreductase 1 (NQO1), and glutamate‐cysteine ligase modifier subunit <t>(GCLM)</t> expression. (B) Protein expression of hepatic GPX4, solute carrier family 7 member 11 (SLC7A11), transferrin receptor 1 (TFR1), and ferritin light chain (FTL). Data are expressed as the mean ± SD ( n = 3). * p < 0.05, ** p < 0.01 and *** p < 0.001 versus CCl 4 group. ### p < 0.001 between the L‐Fx and H‐Fx groups.
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    Image Search Results


    AST attenuated AFB1-induced oxidative stress damage in the liver through the Nrf2 pathway. A Immunoblotting analysis of the protein expression of Keap1, Nrf2, HO-1, NQO1, GCLC and GCLM. The images were merely cropped from the original exposure picture to remove the meaningless parts. B - G The relative levels of the target proteins are shown as histograms representing density readings of the gel bands, and the ratios were calculated relative to the β-actin control. Different capital letters represent P < 0.05

    Journal: BMC Veterinary Research

    Article Title: The dual action of astaxanthin: activating the Nrf2 pathway and suppressing NF-κB to combat AFB1-induced liver injury in broilers

    doi: 10.1186/s12917-026-05330-0

    Figure Lengend Snippet: AST attenuated AFB1-induced oxidative stress damage in the liver through the Nrf2 pathway. A Immunoblotting analysis of the protein expression of Keap1, Nrf2, HO-1, NQO1, GCLC and GCLM. The images were merely cropped from the original exposure picture to remove the meaningless parts. B - G The relative levels of the target proteins are shown as histograms representing density readings of the gel bands, and the ratios were calculated relative to the β-actin control. Different capital letters represent P < 0.05

    Article Snippet: Antibodies to HO-1, NAD(P)H quinone dehydrogenase 1 (NQO1), keap-1, glutamate-cysteine ligase catalytic subunit (GCLC), the modifier subunit (GCLM), P65, P-P65, and IκBα (Proteintech, Boston, MA, USA).

    Techniques: Western Blot, Expressing, Control

    Effect of Fx on Nrf2 and ferroptosis signaling pathways in the liver of CCl 4 ‐induced mice. (A) Protein expression of hepatic Nrf2, heme oxygenase‐1 (HO‐1), nicotinamide quinone oxidoreductase 1 (NQO1), and glutamate‐cysteine ligase modifier subunit (GCLM) expression. (B) Protein expression of hepatic GPX4, solute carrier family 7 member 11 (SLC7A11), transferrin receptor 1 (TFR1), and ferritin light chain (FTL). Data are expressed as the mean ± SD ( n = 3). * p < 0.05, ** p < 0.01 and *** p < 0.001 versus CCl 4 group. ### p < 0.001 between the L‐Fx and H‐Fx groups.

    Journal: Food Science & Nutrition

    Article Title: Fucoxanthin Ameliorates Carbon Tetrachloride‐Induced Liver Fibrosis in Mice via Nrf2/ HO ‐1/ GPX4 ‐Mediated Ferroptosis Pathway

    doi: 10.1002/fsn3.70589

    Figure Lengend Snippet: Effect of Fx on Nrf2 and ferroptosis signaling pathways in the liver of CCl 4 ‐induced mice. (A) Protein expression of hepatic Nrf2, heme oxygenase‐1 (HO‐1), nicotinamide quinone oxidoreductase 1 (NQO1), and glutamate‐cysteine ligase modifier subunit (GCLM) expression. (B) Protein expression of hepatic GPX4, solute carrier family 7 member 11 (SLC7A11), transferrin receptor 1 (TFR1), and ferritin light chain (FTL). Data are expressed as the mean ± SD ( n = 3). * p < 0.05, ** p < 0.01 and *** p < 0.001 versus CCl 4 group. ### p < 0.001 between the L‐Fx and H‐Fx groups.

    Article Snippet: The following primary antibodies were added to the polyvinylidene fluoride membranes: Nrf2 (1: 2000), GPX4 (1:1000), alpha‐smooth muscle actin (α‐SMA) (14395‐1‐AP, 1:2000), solute carrier family 7 member 11 (SLC7A11) (26864‐1‐AP, 1:2000), NAD(P)H:quinone oxidoreductase 1 (NQO1) (67240‐1‐Ig, 1:2000), transferrin receptor 1 (TFR1) (10084‐2‐AP, 1:2000), glutamate‐cysteine ligase modifier subunit (GCLM) (14241‐1‐AP, 1:2000), ferritin light chain (FTL) (10727‐1‐AP, 1:2000), and heme oxygenase‐1 (HO‐1) (66743‐1‐Ig, 1:2000) (Proteintech Inc., Princeton, NJ, USA).

    Techniques: Protein-Protein interactions, Expressing