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spectrum collection library microsource discovery system  (MicroSource Discovery Systems)

 
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    Structured Review

    MicroSource Discovery Systems spectrum collection library microsource discovery system
    Spectrum Collection Library Microsource Discovery System, supplied by MicroSource Discovery Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/microsource+spectrum+collection/microsource+spectrum/pm38834613-329-19-22
    Average 90 stars, based on 1 article reviews
    spectrum collection library microsource discovery system - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Activity Assay:

    Article Title: Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
    Article Snippet: .. The compounds screened for activity against T. tonsurans derived from six collections: (1) MicroSource Spectrum collection (n = 2112; MicroSource Discovery Systems, Gaylordsville, CT), (2) Prestwick Chemical Library (n = 1200 compounds; Prestwick Chemical, Illkirch, France), (3) Enzo FDA-approved drug library (n = 640; Enzo Life Sciences, Farmingdale, NY), (4) Selleck Bioactive compound library (n = 31; Selleck Chemicals, Houston, TX), (5) National Institutes of Health clinical collection (n = 462; NIH, Bethesda, MD), and (6) The University of Kansas Center of Excellence in Chemical Methodologies & Library Development (n = 3376; Lawrence, KS). .. Compounds selected for confirmatory screening were purchased from Sigma-Aldrich (St. Louis, MO), LKT Laboraatories (St. Paul, MN), or Toronto Research Chemicals (Toronto, Canada). at UNIV MASSACHUSETTS BOSTON on September 28, 2015jbx.sagepub.comDownloaded from All compounds were delivered in DMSO at volumes intended to result in a final incubation concentration of 0.5% DMSO.

    Derivative Assay:

    Article Title: Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
    Article Snippet: .. The compounds screened for activity against T. tonsurans derived from six collections: (1) MicroSource Spectrum collection (n = 2112; MicroSource Discovery Systems, Gaylordsville, CT), (2) Prestwick Chemical Library (n = 1200 compounds; Prestwick Chemical, Illkirch, France), (3) Enzo FDA-approved drug library (n = 640; Enzo Life Sciences, Farmingdale, NY), (4) Selleck Bioactive compound library (n = 31; Selleck Chemicals, Houston, TX), (5) National Institutes of Health clinical collection (n = 462; NIH, Bethesda, MD), and (6) The University of Kansas Center of Excellence in Chemical Methodologies & Library Development (n = 3376; Lawrence, KS). .. Compounds selected for confirmatory screening were purchased from Sigma-Aldrich (St. Louis, MO), LKT Laboraatories (St. Paul, MN), or Toronto Research Chemicals (Toronto, Canada). at UNIV MASSACHUSETTS BOSTON on September 28, 2015jbx.sagepub.comDownloaded from All compounds were delivered in DMSO at volumes intended to result in a final incubation concentration of 0.5% DMSO.

    Drug discovery:

    Article Title: Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans.
    Article Snippet: .. The compounds screened for activity against T. tonsurans derived from six collections: (1) MicroSource Spectrum collection (n = 2112; MicroSource Discovery Systems, Gaylordsville, CT), (2) Prestwick Chemical Library (n = 1200 compounds; Prestwick Chemical, Illkirch, France), (3) Enzo FDA-approved drug library (n = 640; Enzo Life Sciences, Farmingdale, NY), (4) Selleck Bioactive compound library (n = 31; Selleck Chemicals, Houston, TX), (5) National Institutes of Health clinical collection (n = 462; NIH, Bethesda, MD), and (6) The University of Kansas Center of Excellence in Chemical Methodologies & Library Development (n = 3376; Lawrence, KS). .. Compounds selected for confirmatory screening were purchased from Sigma-Aldrich (St. Louis, MO), LKT Laboraatories (St. Paul, MN), or Toronto Research Chemicals (Toronto, Canada). at UNIV MASSACHUSETTS BOSTON on September 28, 2015jbx.sagepub.comDownloaded from All compounds were delivered in DMSO at volumes intended to result in a final incubation concentration of 0.5% DMSO.

    Article Title: The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13
    Article Snippet: .. The MicroSource Spectrum Collection compound library, and clofoctol for further use, were purchased from MicroSource Discovery Inc. .. Cell apoptosis analysis was performed using a FITC Annexin V Apoptosis Detection Kit I (catalog 55647, BD Pharmingen).

    In Vitro:

    Article Title: Dengue drug discovery: Progress, challenges and outlook.
    Article Snippet: Accepted Manuscript Dengue drug discovery: Progress, challenges and outlook Siew Pheng Lim PII: S0166-3542(18)30562-X DOI: https://doi.org/10.1016/j.antiviral.2018.12.016 Reference: AVR 4440 To appear in: Antiviral Research Received Date: 17 September 2018 Revised Date: 22 December 2018 Accepted Date: 25 December 2018 Please cite this article as: Lim, S.P., Dengue drug discovery: Progress, challenges and outlook, Antiviral Research (2019), doi: https://doi.org/10.1016/j.antiviral.2018.12.016.. This is a PDF file of an unedited manuscript that has been accepted for publication.. As a service to our customers we are providing this early version of the manuscript.

    Protease Assay:

    Article Title: Dengue drug discovery: Progress, challenges and outlook.
    Article Snippet: Accepted Manuscript Dengue drug discovery: Progress, challenges and outlook Siew Pheng Lim PII: S0166-3542(18)30562-X DOI: https://doi.org/10.1016/j.antiviral.2018.12.016 Reference: AVR 4440 To appear in: Antiviral Research Received Date: 17 September 2018 Revised Date: 22 December 2018 Accepted Date: 25 December 2018 Please cite this article as: Lim, S.P., Dengue drug discovery: Progress, challenges and outlook, Antiviral Research (2019), doi: https://doi.org/10.1016/j.antiviral.2018.12.016.. This is a PDF file of an unedited manuscript that has been accepted for publication.. As a service to our customers we are providing this early version of the manuscript.

    Inhibition:

    Article Title: Dengue drug discovery: Progress, challenges and outlook.
    Article Snippet: Accepted Manuscript Dengue drug discovery: Progress, challenges and outlook Siew Pheng Lim PII: S0166-3542(18)30562-X DOI: https://doi.org/10.1016/j.antiviral.2018.12.016 Reference: AVR 4440 To appear in: Antiviral Research Received Date: 17 September 2018 Revised Date: 22 December 2018 Accepted Date: 25 December 2018 Please cite this article as: Lim, S.P., Dengue drug discovery: Progress, challenges and outlook, Antiviral Research (2019), doi: https://doi.org/10.1016/j.antiviral.2018.12.016.. This is a PDF file of an unedited manuscript that has been accepted for publication.. As a service to our customers we are providing this early version of the manuscript.

    Biomarker Discovery:

    Article Title: Dengue drug discovery: Progress, challenges and outlook.
    Article Snippet: Accepted Manuscript Dengue drug discovery: Progress, challenges and outlook Siew Pheng Lim PII: S0166-3542(18)30562-X DOI: https://doi.org/10.1016/j.antiviral.2018.12.016 Reference: AVR 4440 To appear in: Antiviral Research Received Date: 17 September 2018 Revised Date: 22 December 2018 Accepted Date: 25 December 2018 Please cite this article as: Lim, S.P., Dengue drug discovery: Progress, challenges and outlook, Antiviral Research (2019), doi: https://doi.org/10.1016/j.antiviral.2018.12.016.. This is a PDF file of an unedited manuscript that has been accepted for publication.. As a service to our customers we are providing this early version of the manuscript.

    other:

    Article Title: α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention
    Article Snippet: The Microsource Spectrum Collection and small-molecule library containing 2560 compounds included in the US and International Drug Collections, together with Natural Product and Discover libraries, was purchased from Microsource Discovery Systems, Inc. DMSO and H 2 O 2 (30%) were from Thermo Fisher Scientific.

    Fluorescence:

    Article Title: Novel Insights into RAD52's Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies.
    Article Snippet: .. In 2016, Hengel and colleagues conducted a fluorescence resonance energy transfer (FRET)-based HTS of the MicroSource SPECTRUM collection (MicroSource Discovery systems) associated with a virtual screening campaign. ..

    Förster Resonance Energy Transfer:

    Article Title: Novel Insights into RAD52's Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies.
    Article Snippet: .. In 2016, Hengel and colleagues conducted a fluorescence resonance energy transfer (FRET)-based HTS of the MicroSource SPECTRUM collection (MicroSource Discovery systems) associated with a virtual screening campaign. ..

    Incubation:

    Article Title: Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy
    Article Snippet: .. Groups of 12 larvae were incubated with 4 compounds, 10 μM each in DMSO 0.1%, from the 2560 compounds of the Microsource Spectrum Collection (MicroSource Discovery Systems Inc.) from 4 to 7 days after fertilization. ..



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    Figure 3. (A) Shown are the results of the PNT domain PCA with compound plates from the Prestwick (335, 338, 339), Biomol (342), Sigma (348, 355), and <t>Microsource</t> (368) libraries. The circles represent the luminescence reading of each well of a 96-well plate. The red bars represent the mean relative luminescence and standard deviation of that plate. Pink circles represent wells that were exposed to only DMSO. An initial screening hit is defined as being more than 2 standard deviations away from the mean (blue circles). (B) Compounds identified as hits in the initial high-throughput screen were retested for a concentration-dependent response in the PNT domain and leucine zipper PCAs. Compounds were tested in duplicate at 1, 3, 10, and 30 µM, and cells were visually examined to determine toxicity or compound precipitation. Those that were not cytotoxic and elicited a similar response in both PCA systems were likely inhibitors of split luciferase reconstitution, luciferase activity itself, or another variable. Compounds 1 and 2 represent examples of artifacts of the original, large-scale screen, whereas compounds 3–5 represent examples of concentration- dependent responses. Compound 1, (±)-pindobind; compound 2, gitoxigenin diacetate; compound 3, rosolic acid; compound 4, gambogic acid amide; compound 5, 3,4-dimethoxydalbergione.
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    Image Search Results


    Figure 3. (A) Shown are the results of the PNT domain PCA with compound plates from the Prestwick (335, 338, 339), Biomol (342), Sigma (348, 355), and Microsource (368) libraries. The circles represent the luminescence reading of each well of a 96-well plate. The red bars represent the mean relative luminescence and standard deviation of that plate. Pink circles represent wells that were exposed to only DMSO. An initial screening hit is defined as being more than 2 standard deviations away from the mean (blue circles). (B) Compounds identified as hits in the initial high-throughput screen were retested for a concentration-dependent response in the PNT domain and leucine zipper PCAs. Compounds were tested in duplicate at 1, 3, 10, and 30 µM, and cells were visually examined to determine toxicity or compound precipitation. Those that were not cytotoxic and elicited a similar response in both PCA systems were likely inhibitors of split luciferase reconstitution, luciferase activity itself, or another variable. Compounds 1 and 2 represent examples of artifacts of the original, large-scale screen, whereas compounds 3–5 represent examples of concentration- dependent responses. Compound 1, (±)-pindobind; compound 2, gitoxigenin diacetate; compound 3, rosolic acid; compound 4, gambogic acid amide; compound 5, 3,4-dimethoxydalbergione.

    Journal: SLAS discovery : advancing life sciences R & D

    Article Title: A Multipronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization.

    doi: 10.1177/2472555220979599

    Figure Lengend Snippet: Figure 3. (A) Shown are the results of the PNT domain PCA with compound plates from the Prestwick (335, 338, 339), Biomol (342), Sigma (348, 355), and Microsource (368) libraries. The circles represent the luminescence reading of each well of a 96-well plate. The red bars represent the mean relative luminescence and standard deviation of that plate. Pink circles represent wells that were exposed to only DMSO. An initial screening hit is defined as being more than 2 standard deviations away from the mean (blue circles). (B) Compounds identified as hits in the initial high-throughput screen were retested for a concentration-dependent response in the PNT domain and leucine zipper PCAs. Compounds were tested in duplicate at 1, 3, 10, and 30 µM, and cells were visually examined to determine toxicity or compound precipitation. Those that were not cytotoxic and elicited a similar response in both PCA systems were likely inhibitors of split luciferase reconstitution, luciferase activity itself, or another variable. Compounds 1 and 2 represent examples of artifacts of the original, large-scale screen, whereas compounds 3–5 represent examples of concentration- dependent responses. Compound 1, (±)-pindobind; compound 2, gitoxigenin diacetate; compound 3, rosolic acid; compound 4, gambogic acid amide; compound 5, 3,4-dimethoxydalbergione.

    Article Snippet: Screening compounds for the cellular assays consisted of 16,000 compounds from the Maybridge Hitfinder collection, 10,000 compounds from the ChemBridge DIVERset collection, 1120 compounds from Prestwick Chemicals, 1280 compounds from the Sigma LOPAC library, 2000 compounds from the Microsource Spectrum collection, 2697 compounds from the Selleck L1700 Bioactive Compound library, and 500 compounds from Biomol.

    Techniques: Standard Deviation, High Throughput Screening Assay, Concentration Assay, Luciferase, Activity Assay