microelectrode array (mea) system maestro pro (Axion BioSystems)
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Axion BioSystems
microelectrode array (mea) system maestro pro
Microelectrode Array (Mea) System Maestro Pro, supplied by Axion BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microelectrode+array+(mea)+system+maestro+pro/cytoview+mea+24+well+plates/pm40435813-101-9-16
Average 90 stars, based on 1 article reviews
Microelectrode Array (Mea) System Maestro Pro, supplied by Axion BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microelectrode+array+(mea)+system+maestro+pro/cytoview+mea+24+well+plates/pm40435813-101-9-16
Average 90 stars, based on 1 article reviews
microelectrode array (mea) system maestro pro - by Bioz Stars,
2026-11
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other:Article Title: Graphene-polymer nanofibers enable optically induced electrical responses in stem cell-derived electrically excitable cells and brain organoids. Article Snippet: Human pluripotent stem cell (hPSC)-derived electrically excitable cells provide a unique window into development, but they remain electrically immature partially due to the lack of chronic stimulation.. Here, we fabricated electrospun polymer nanofibers containing light-reactive reduced graphene oxide (rGO) as part of a new classes of on-demand, electrically active biomaterials to enhance cell function.. Fiber size, stiffness, and electrical conductivity varied with rGO concentration, which impacted hPSC-derived cardiomyocyte and neuron responses; with acute light stimulation, cardiomyocytes exhibited increased, synchronous calcium handling. Article Title: Exome Sequencing of 963 Chinese Families Identifies Novel Epilepsy Candidate Genes Article Snippet: To further investigate functional connectivity across a range of temporal scales, we utilized a Microelectrode Array:Article Title: Circadian clocks in human cerebral organoids Article Snippet: .. For monolayers and organoids we used the Article Title: Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway. Article Snippet: .. We recorded neuronal activity of the cell cultures in the 48-well MEA using the Article Title: Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP Article Snippet: .. Spontaneous extracellular field potentials were acquired at 37°C using a Article Title: Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP Article Snippet: .. Spontaneous extracellular field potentials were acquired at 37°C using a Article Title: Transcription factor combinations that define human astrocyte identity encode significant variation of maturity and function. Article Snippet: .. Recordings were performed for 20 min every week until day 42 post induction of iNs using Activity Assay:Article Title: Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway. Article Snippet: .. We recorded neuronal activity of the cell cultures in the 48-well MEA using the Software:Article Title: Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP Article Snippet: .. Spontaneous extracellular field potentials were acquired at 37°C using a Article Title: Activation of IP 3 R in atrial cardiomyocytes leads to generation of cytosolic cAMP Article Snippet: .. Spontaneous extracellular field potentials were acquired at 37°C using a |
![a, PKP2 Hom showed increase in lipid granules and no change in lipid uptake compared to WT isogenic cell quantified by confocal imaging using two lipid dyes, QBT Fatty Acid Uptake (Molecular Devices) for measuring real-time fatty acid uptake (FAU) (n = 59-90 technical replicates) and LipidSpot 610 for measuring fatty acid storage in fixed iPSC cardiomyocytes after performing FAU (n = 12-18 technical replicates). b, FIA-TOF mass spectrometry measurement showed reduced acylcarnitines in PKP2 Hom compared to WT isogenic cells (n = 6 technical replicates, 3 wells of 12-well plate were pooled as 1 technical replicate). c, PKP2 Hom showed reduced glycolytic and oxidative metabolism evaluated by the Seahorse MitoStress test (n = 14-43 technical replicates). Top kinetic curves indicated where basal or vehicle/etomoxir-induced ATP rates were calculated. d, Monolayers MEA parameters showed prolonged field potential duration (FPD) along with depressed spike amplitude, conduction velocity, and spike slope using the Maestro Pro <t>Microelectrode</t> array (MEA) platform (Axion Biosystems) 58 (n = 15 technical replicates). e, Monolayers (n = 24 technical replicates) and engineered heart tissues (EHTs) (n = 16 technical replicates) showed reduced contraction force and velocity, and prolonged contraction and relaxation time in the mutant lines using SONY live cell imaging and Pulse video analysis (Curi Bio) 55 and Mantarray (Curi Bio) 57 and Pulse video analysis (Curi Bio), respectively. f, Calcium transient recordings from WT and PKP2 Hom (n = 12 technical replicates each) assessed with CuriBio Nautilai ( https://www.curibio.com/nautilai ). Parameters displayed are: time to peak from 50% to peak (T 50 -Peak), Ca 2+ transient width at 50% (CaD50), and the rate at which [Ca 2+] i reach its peak (Rise Rate). g, Acute PKP2 vs ACADVL silencing showed differential impact on field potential, contractility, and calcium transient of iPSC-CMs (details in Supplementary Fig. 4). Quantified data are presented as mean ± SD. Comparison p values were calculated by Prism unpaired t-test and ordinary One-Way ANOVA (Tukey’s post-hoc test) for c and g : p values: *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, ns = non-significant.](https://bio-rxiv-images-cdn.bioz.com/dois_ending_with_39/10__1101_slash_2025__01__17__633239/10__1101_slash_2025__01__17__633239___F5.large.jpg)
![a, Study design to evaluate small-molecule metabolic modulators in isogenic Pkp2 homozygous cell model. Monolayers or engineered heart tissues (EHTs) were treated with isoproterenol or seladelpar for 1 and 48 hours before the measurement on contractility, bioenergetics, electrophysiological properties (field potential), and Ca 2+ transients. b, WT and isogenic PKP2 Hom cells were treated pharmacologically with DMSO, isoproterenol (ISO), AZD7687 (AZD), etomoxir (ETO), bezafibrate (BEZ), seladelpar (SEL), and phenformin (PHE). Contractility was evaluated at 1 and 48 hrs post treatment using SONY live cell imaging and Pulse video analysis (n = 18-48 technical replicates) (Curi Bio) 55 . Average nuclear counts from live cells were used to normalize contraction velocity. c, In response to isoproterenol or seladelpar treatment, glycoATP and mitoATP rates and Max OCR of WT and isogenic PKP2 Hom cells were quantified using the Seahorse MitoStress test (n = 4-18 technical replicates). Statistical significance within the genotypes was determined at 48 hours post post-vehicle control/small molecule administration using Prism one-way ANOVA (Tukey’s post-hoc test). d, Assessment of normalized twitch force, contraction and relaxation velocity in WT and PKP2 Hom generated 3D-EHTs 1 hour or 48 hours post-vehicle control/small molecule administration (n = 8-11 technical replicates) using Mantarray (Curi Bio) 57 and Pulse video analysis (Curi Bio) 55 . e, Assessment of field potential parameters, spike amplitude and spike slope, in WT and PKP2 Hom monolayers at 48-day post-vehicle control/small molecule administration using Maestro Pro Microelectrode array (MEA) platform (Axion Biosystems) 58 . Data were analyzed through AxIS Navigator software and the Cardiac Analysis Tool (Axion Biosystems) (n = 12 technical replicates). f, Calcium transient recordings from WT and PKP2 Hom monolayers (n = 12 technical replicates) or 3D engineered heart tissues (EHTs) (n = 3-4 technical replicates) were evaluated with CuriBio Nautilai ( https://www.curibio.com/nautilai ), multiwell format, and analyzed by Curi Bio’s Pulse platform 55 . Parameters shown are: time to peak from 50% to peak (T 50 -Peak), the rate at which [Ca 2+] i reach its peak (Rise Rate), and half-width/Ca 2+ transient width at 50% (CaD50). Data are presented as mean ± standard deviation (s.d.). Statistical significance was determined using Prism one-way ANOVA (Tukey’s post-hoc test): p values are indicated as follows: *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.](https://bio-rxiv-images-cdn.bioz.com/dois_ending_with_39/10__1101_slash_2025__01__17__633239/10__1101_slash_2025__01__17__633239___F6.large.jpg)
