macpymol (DeLano Scientific)
90
Structured Review
DeLano Scientific
macpymol
Macpymol, supplied by DeLano Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/macpymol/macpymol/pm40577121-326-0-1
Average 90 stars, based on 1 article reviews
Macpymol, supplied by DeLano Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/macpymol/macpymol/pm40577121-326-0-1
Average 90 stars, based on 1 article reviews
macpymol - by Bioz Stars,
2026-10
90/100 stars
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other:Article Title: Characterization and Structural Analysis of a Novel exo-Type Enzyme Acting on β-1,2-Glucooligosaccharides from Parabacteroides distasonis. Article Snippet: β-1,2-Glucan is a polysaccharide produced mainly by some Gram-negative bacteria as a symbiosis and infectious factor.. We recently identified endo-β-1,2-glucanase from Chitinophaga pinensis (CpSGL) as an enzyme comprising a new family.. Here, we report the characteristics and crystal structure of a CpSGL homolog from Parabacteroides distasonis, an intestinal bacterium (BDI_3064 protein), which exhibits distinctive properties of known β-1,2-glucan-degrading enzymes. Article Title: An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen Article Snippet: Selection:Article Title: The Evolution of the Mammalian ABCA6 -like Genes: Analysis of Phylogenetic, Expression, and Population Genetic Data Reveals Complex Evolutionary Histories Article Snippet: .. Amino acid sites identified as under positive selection in the ungapped alignments were matched to positionally homologous sites in the cryo-EM structure of human ABCA1 (PDB ID: 5XJY) via a multiple sequence alignment using MUSCLE ( ) and subsequently visualized in Sequencing:Article Title: The Evolution of the Mammalian ABCA6 -like Genes: Analysis of Phylogenetic, Expression, and Population Genetic Data Reveals Complex Evolutionary Histories Article Snippet: .. Amino acid sites identified as under positive selection in the ungapped alignments were matched to positionally homologous sites in the cryo-EM structure of human ABCA1 (PDB ID: 5XJY) via a multiple sequence alignment using MUSCLE ( ) and subsequently visualized in Generated:Article Title: Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets Article Snippet: .. All structure figures were generated with Binding Assay:Article Title: A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA Article Snippet: .. The surface area buried upon Fab binding was calculated using MS . |
![Type IB DNA topoisomerase. a) Human TOP1B (TOPO70) crystal structure with DNA and topotecan (TPT). Surface representation of the N-terminally truncated TOPO70 (lacking the first 174 residues) in orange with DNA (sticks) and TPT (blue balls), PDB# 1K4T [100]. All structure figures were generated using MacPyMol <t>0.99rc6</t> (DeLano Scientific, San Carlos, CA). b) Schematic representation of eukaryotic DNA topoisomerase I (TOP1B) catalytic cycle where the covalent enzyme-DNA intermediate constitutes the sole cellular target of camptothecin (CPT). Topotecan and irinotecan as FDA approved CPT analogs. TOP1B non-covalently circumscribes duplex DNA. The active side tyrosine cleaves one strand forming a 3’phospho-tyrosyl bond, which covalently links the enzyme to the 3’end of DNA. After DNA relaxation by a controlled rotation mechanism, the DNA ends religate and TOP1B may dissociate from the DNA. CPT intercalates into the cleavage site preventing religation of the DNA ends. The reversible drug-stabilized enzyme-DNA complex can be converted into lethal DNA lesions in collisions with processive replication or transcription machinery. See text for more details](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_4606/pmc09254606/pmc09254606__nihms-878366-f0002.jpg)