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inhibitor effects  (MedChemExpress)


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    MedChemExpress inhibitor effects
    Inhibitor Effects, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/inhibitor+effects/AP-18/pmc13001051-64-4-12
    Average 94 stars, based on 3 article reviews
    inhibitor effects - by Bioz Stars, 2026-11
    94/100 stars

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    other:

    Article Title: TRPA1-kinase axis polarization: Nepetalactone drives pest repulsion and predator attraction via divergent PKC/CaMKII signaling.
    Article Snippet: To assess nepetalactone and inhibitor effects (AP-18: Cat# HY-W014421; HC-030031: Cat# HY-15064; MedChemExpress, China), cohorts of at least twenty females were collected at 0.5, 1, 3, and 6 h post-treatment.

    Article Title: TRPA1-kinase axis polarization: Nepetalactone drives pest repulsion and predator attraction via divergent PKC/CaMKII signaling
    Article Snippet: At 48 h post-transfection, calcium flux kinetics was recorded using a BioTek Synergy H1 multimode microplate reader (Agilent, USA) under standardized protocol: (1) baseline stabilization (0–30 s); (2) automated nepetalactone injection (100 μM final); (3) continuous monitoring across 40–350 s. Background-subtracted ΔF/F0 values were integrated as area-under-curve (AUC) using GraphPad Prism 8.0.



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    Image Search Results


    Erianin attenuated UM both in vitro and in vivo. ( A ) Heatmap of natural product screening results in PIG1, OMM2.3, and 92-1 cells upon treatment with DMSO or inhibitors (10 µM) for 3 days ( n = 3). ( B ) The chemical structure of erianin. ( C ) IC 50 of erianin in PIG1, MEL290, 92-1, and OMM2.3 cell lines. ( D ) CCK-8 assay showing cell viability of UM cells (OMM2.3 and 92-1) upon erianin treatment ( n = 3). ** P < 0.01, *** P < 0.001, **** P < 0.0001. ( E , F ) A colony formation assay was performed to assess the growth of UM cells (OMM2.3 and 92-1) upon erianin treatment ( n = 3). The data are presented as the mean ± SD of experimental triplicates. * P < 0.05, ** P < 0.01. ( G , H ) A Transwell assay was performed to assess the growth of UM cells (OMM2.3 and 92-1) upon erianin treatment ( n = 3). The data are presented as the mean ± SD of experimental triplicates. ** P < 0.01, *** P < 0.001; ns, no significance. ( I , J ) Images of eyeballs containing xenografts derived from OMM2.3 cells and statistical analysis of the eyeball weight data ( n = 7). Hematoxylin and eosin staining to evaluate tumor formation. The data are presented as mean ± SD. **** P < 0.0001.

    Journal: Investigative Ophthalmology & Visual Science

    Article Title: Erianin Abrogates Cancerous Vasculogenic Mimicry Through Targeting m 5 C Methylase NSUN2 in Uveal Melanoma

    doi: 10.1167/iovs.66.15.47

    Figure Lengend Snippet: Erianin attenuated UM both in vitro and in vivo. ( A ) Heatmap of natural product screening results in PIG1, OMM2.3, and 92-1 cells upon treatment with DMSO or inhibitors (10 µM) for 3 days ( n = 3). ( B ) The chemical structure of erianin. ( C ) IC 50 of erianin in PIG1, MEL290, 92-1, and OMM2.3 cell lines. ( D ) CCK-8 assay showing cell viability of UM cells (OMM2.3 and 92-1) upon erianin treatment ( n = 3). ** P < 0.01, *** P < 0.001, **** P < 0.0001. ( E , F ) A colony formation assay was performed to assess the growth of UM cells (OMM2.3 and 92-1) upon erianin treatment ( n = 3). The data are presented as the mean ± SD of experimental triplicates. * P < 0.05, ** P < 0.01. ( G , H ) A Transwell assay was performed to assess the growth of UM cells (OMM2.3 and 92-1) upon erianin treatment ( n = 3). The data are presented as the mean ± SD of experimental triplicates. ** P < 0.01, *** P < 0.001; ns, no significance. ( I , J ) Images of eyeballs containing xenografts derived from OMM2.3 cells and statistical analysis of the eyeball weight data ( n = 7). Hematoxylin and eosin staining to evaluate tumor formation. The data are presented as mean ± SD. **** P < 0.0001.

    Article Snippet: To identify effective natural inhibitors of UM, we first performed natural product library screening (TargetMol L6000) at a concentration of 10 μM for each compound , and DMSO served as the control group.

    Techniques: In Vitro, In Vivo, CCK-8 Assay, Colony Assay, Transwell Assay, Derivative Assay, Staining