Journal: Frontiers in Pharmacology
Article Title: Herb-Drug Interaction Between Xiyanping Injection and Lopinavir/Ritonavir, Two Agents Used in COVID-19 Pharmacotherapy
doi: 10.3389/fphar.2021.773126
Figure Lengend Snippet: LC-MS/MS chromatograms of (A) blank plasma (B) blank plasma spiked with LPV (3,000 ng/ml), RTV (300 ng/ml), and indinavir as the IS (100 ng/ml) (C) plasma at 3 h after oral administration of LPV/RTV (42:10.5 mg/kg).
Article Snippet: RTV, LPV, and indinavir sulfate were purchased from Macklin Inc. (Shanghai, China); testosterone was purchased from Sigma-Aldrich (St. Louis, MO, United States); 6β-hydroxytestosterone was purchased from Toronto Research Chemicals Inc. (Toronto, Canada); β-nicotinamide adenine dinucleotide phosphate (NADPH) was purchased from Roche (Roche, Switzerland); propranolol was obtained from the National Institutes for Food and Drug Control (Beijing, China); Solutol HS-15 was purchased from MedChemExpress LLC (Shanghai, China); and XYPI was purchased from Jiangxi Qingfeng Pharmaceutical Co. Ltd. (Jiangxi, China).
Techniques: Liquid Chromatography with Mass Spectroscopy, Clinical Proteomics