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ATCC cells
Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 7224 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cells/product/ATCC
Average 99 stars, based on 7224 article reviews

cells - by Bioz Stars, 2026-02

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Nuclear pore protein relative transcript levels (Log 2 FC) following cell differentiation. Cell states: RA/0, granulocytes compared to undifferentiated HL-60/S4 cells; TPA/0, macrophages compared to undifferentiated HL-60/S4 cells. Seven NPC structural regions are indicated, with resident gene names clustered together. A recent reclassification of NPC structural regions with resident clustered gene names has been published . See for a summary of the differences between some gene clusters and some gene names compared to those employed in the present study.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Nuclear pore protein relative transcript levels (Log 2 FC) following cell differentiation. Cell states: RA/0, granulocytes compared to undifferentiated HL-60/S4 cells; TPA/0, macrophages compared to undifferentiated HL-60/S4 cells. Seven NPC structural regions are indicated, with resident gene names clustered together. A recent reclassification of NPC structural regions with resident clustered gene names has been published . See for a summary of the differences between some gene clusters and some gene names compared to those employed in the present study.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Cell Differentiation

Nuclear pore protein relative transcript levels (Log 2 FC) in HL-60/sh1 0 cells, where the nuclear envelope protein LBR transcript has been knocked-down (sh1 cells). Cell states: undifferentiated (sh1 0) cells compared to undifferentiated (S4 0) HL-60/S4 cells. Seven NPC structural regions are indicated, with resident gene names clustered together as in .

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Nuclear pore protein relative transcript levels (Log 2 FC) in HL-60/sh1 0 cells, where the nuclear envelope protein LBR transcript has been knocked-down (sh1 cells). Cell states: undifferentiated (sh1 0) cells compared to undifferentiated (S4 0) HL-60/S4 cells. Seven NPC structural regions are indicated, with resident gene names clustered together as in .

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques:

Nuclear pore protein transcript levels (Log 2 FC) during sucrose produced hyperosmotic cellular dehydration. Cell states: 30 min dehydration of undifferentiated HL-60/S4 cells compared to control undifferentiated HL-60/S4 cells (30 min/0 min); 60 min dehydration of undifferentiated HL-60/S4 cells compared to control undifferentiated HL-60/S4 cells (60 min/0 min). Seven NPC structural regions are indicated, with resident gene names clustered together.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Nuclear pore protein transcript levels (Log 2 FC) during sucrose produced hyperosmotic cellular dehydration. Cell states: 30 min dehydration of undifferentiated HL-60/S4 cells compared to control undifferentiated HL-60/S4 cells (30 min/0 min); 60 min dehydration of undifferentiated HL-60/S4 cells compared to control undifferentiated HL-60/S4 cells (60 min/0 min). Seven NPC structural regions are indicated, with resident gene names clustered together.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Produced, Control

Immunostaining of an undifferentiated HL-60/S4 cells with two different antibodies: Mouse anti-nuclear pores complexes (Mab 414), Red; Rabbit anti-Lamin A/C, Green, combined with DAPI, Blue. Note the enrichment of NPCs in the vicinity of the nuclear envelope, which is highlighted by Lamin A/C staining. All images are deconvolved. The magnification bar represents 10 μm.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Immunostaining of an undifferentiated HL-60/S4 cells with two different antibodies: Mouse anti-nuclear pores complexes (Mab 414), Red; Rabbit anti-Lamin A/C, Green, combined with DAPI, Blue. Note the enrichment of NPCs in the vicinity of the nuclear envelope, which is highlighted by Lamin A/C staining. All images are deconvolved. The magnification bar represents 10 μm.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Immunostaining, Staining

Importins, Transportins and Exportins relative transcript levels (Log 2 FC) following cell differentiation. Cell states: RA/0, granulocytes compared to undifferentiated HL-60/S4 cells; TPA/0, macrophages compared to undifferentiated HL-60/S4 cells. The open bars indicate lower statistical significance (PPDE <0.95); solid bars indicate higher statistical significance (PPDE > 0.95).

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Importins, Transportins and Exportins relative transcript levels (Log 2 FC) following cell differentiation. Cell states: RA/0, granulocytes compared to undifferentiated HL-60/S4 cells; TPA/0, macrophages compared to undifferentiated HL-60/S4 cells. The open bars indicate lower statistical significance (PPDE <0.95); solid bars indicate higher statistical significance (PPDE > 0.95).

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Cell Differentiation

Electron microscope images of control (a) and RA-differentiated HL-60/S4 granulocytes (b, c, d, e, and f) displaying nuclear lobulation, nuclear pores and a profusion of ELCS connected to the nuclear lobes. Top Row: NPCs (open arrow heads) at the nuclear envelope of a control (undifferentiated) HL-60/S4 cell (a); Granulocytes with NPCs in nuclear lobe envelopes (b and c). ELCS are identified by thin arrows. Bottom Row: A thin section of a single HL-60/S4 granulocyte displaying a nuclear lobe affiliated with numerous ELCS (d); Two magnified regions from the same granulocyte (d) exhibit nuclear pores adjacent to surrounding ELCS (e and f) probably at the surface of microlobes. Magnification bars: a, 100 nm; b, 500 nm; c, 500 nm; d, 3 μm; e, 500 nm; f, 500 nm.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Electron microscope images of control (a) and RA-differentiated HL-60/S4 granulocytes (b, c, d, e, and f) displaying nuclear lobulation, nuclear pores and a profusion of ELCS connected to the nuclear lobes. Top Row: NPCs (open arrow heads) at the nuclear envelope of a control (undifferentiated) HL-60/S4 cell (a); Granulocytes with NPCs in nuclear lobe envelopes (b and c). ELCS are identified by thin arrows. Bottom Row: A thin section of a single HL-60/S4 granulocyte displaying a nuclear lobe affiliated with numerous ELCS (d); Two magnified regions from the same granulocyte (d) exhibit nuclear pores adjacent to surrounding ELCS (e and f) probably at the surface of microlobes. Magnification bars: a, 100 nm; b, 500 nm; c, 500 nm; d, 3 μm; e, 500 nm; f, 500 nm.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Microscopy, Control

Immunostaining of a differentiated HL-60/S4 cell granulocyte with Mouse anti-nuclear pore complexes [Mab 414] (Red dots) and with DAPI (Cyan). Note the enrichment of NPCs at the surface of nuclear lobes and within the ELCS region (indicated by arrows in the DAPI image). All images are deconvolved. The magnification bar represents 10 μm.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Immunostaining of a differentiated HL-60/S4 cell granulocyte with Mouse anti-nuclear pore complexes [Mab 414] (Red dots) and with DAPI (Cyan). Note the enrichment of NPCs at the surface of nuclear lobes and within the ELCS region (indicated by arrows in the DAPI image). All images are deconvolved. The magnification bar represents 10 μm.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Immunostaining

Importins, Transportins and Exportins relative transcript levels (Log 2 FC). Cell states: undifferentiated HL-60/sh1 0 cells compared to undifferentiated HL-60/S4 0 cells. The hollow bar indicates a lower statistical significance (PPDE <0.95); solid bars indicate a PPDE > 0.95.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Importins, Transportins and Exportins relative transcript levels (Log 2 FC). Cell states: undifferentiated HL-60/sh1 0 cells compared to undifferentiated HL-60/S4 0 cells. The hollow bar indicates a lower statistical significance (PPDE <0.95); solid bars indicate a PPDE > 0.95.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques:

GSEA plots with four different nuclear pore structure gene sets. The number of genes in each gene set are shown at the bottom of each plot. The plots display undifferentiated (HL-60/sh1 0) cells compared to undifferentiated (HL-60/S4 0 cells). From the shape of these plots and the increased density of ranked genes at the sh1 0 phenotype location, it is clear that most of the genes of each gene set are over-represented in the LBR knockdown (sh1 0) phenotype region, implying that nuclear pore structure is not adversely affected by loss of LBR.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: GSEA plots with four different nuclear pore structure gene sets. The number of genes in each gene set are shown at the bottom of each plot. The plots display undifferentiated (HL-60/sh1 0) cells compared to undifferentiated (HL-60/S4 0 cells). From the shape of these plots and the increased density of ranked genes at the sh1 0 phenotype location, it is clear that most of the genes of each gene set are over-represented in the LBR knockdown (sh1 0) phenotype region, implying that nuclear pore structure is not adversely affected by loss of LBR.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Knockdown

GSEA plots with four different nuclear transport gene sets. The number of genes in each gene set are shown at the bottom of each plot. The plots display undifferentiated HL-60/sh1 0 cells compared to undifferentiated HL-60/S4 0 cells. From the shape of these plots and the increased density of ranked genes at the sh1 0 phenotype location, it is clear that most of the genes of each gene set are over-represented in the LBR knockdown (sh1 0) phenotype region, implying that nuclear pore transport function is not adversely affected by loss of LBR.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: GSEA plots with four different nuclear transport gene sets. The number of genes in each gene set are shown at the bottom of each plot. The plots display undifferentiated HL-60/sh1 0 cells compared to undifferentiated HL-60/S4 0 cells. From the shape of these plots and the increased density of ranked genes at the sh1 0 phenotype location, it is clear that most of the genes of each gene set are over-represented in the LBR knockdown (sh1 0) phenotype region, implying that nuclear pore transport function is not adversely affected by loss of LBR.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Knockdown

Importins, Transportins and Exportins transcript levels (Log2FC) during cell dehydration. Cell states: 30 min dehydration of HL-60/S4 cells, compared to control HL-60/S4 cells (30 min/0 min); 60 min dehydration of HL-60/S4 cells compared to control HL-60/S4 cells (60 min/0 min). Hollow bars indicate a lower statistical significance (PPDE <0.95); solid bars indicate a PPDE > 0.95.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Importins, Transportins and Exportins transcript levels (Log2FC) during cell dehydration. Cell states: 30 min dehydration of HL-60/S4 cells, compared to control HL-60/S4 cells (30 min/0 min); 60 min dehydration of HL-60/S4 cells compared to control HL-60/S4 cells (60 min/0 min). Hollow bars indicate a lower statistical significance (PPDE <0.95); solid bars indicate a PPDE > 0.95.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Control

GSEA plots with three different nuclear pore structure gene sets. The number of genes in each gene set are shown at the bottom of each plot. The plots display HL-60/S4 0 cells exposed to hyperosmotic conditions (medium+300 mM sucrose) compared to control HL-60/S4 0 cells in isosmotic medium. Top row: 30 minutes of sucrose; Bottom Row, 60 minutes of sucrose. From the shape of these plots and the increased density of ranked genes at the control (0) phenotype location, it is clear that most of the genes in each gene set are underrepresented in the hyperosmotically-stressed cell (30 and 60 min) phenotype regions, implying that nuclear pore organization is not “normal” in the dehydrated state.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: GSEA plots with three different nuclear pore structure gene sets. The number of genes in each gene set are shown at the bottom of each plot. The plots display HL-60/S4 0 cells exposed to hyperosmotic conditions (medium+300 mM sucrose) compared to control HL-60/S4 0 cells in isosmotic medium. Top row: 30 minutes of sucrose; Bottom Row, 60 minutes of sucrose. From the shape of these plots and the increased density of ranked genes at the control (0) phenotype location, it is clear that most of the genes in each gene set are underrepresented in the hyperosmotically-stressed cell (30 and 60 min) phenotype regions, implying that nuclear pore organization is not “normal” in the dehydrated state.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Control

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: GSEA plots with four different nuclear transport gene sets. The number of genes in each gene set are shown at the bottom of each plot. The plots display HL-60/S4 0 cells exposed to hyperosmotic conditions (medium+300 mM sucrose) compared to control HL-60/S4 0 cells in isosmotic medium. Top row: 30 minutes of sucrose; Bottom Row, 60 minutes of sucrose. From the shape of these plots and the increased density of ranked genes at the control (0) phenotype location, it is clear that most of the genes in each gene set are underrepresented in the hyperosmotically stressed cells (30 and 60 min), implying that nuclear pore function is disabled in the dehydrated state.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Control

Immunostaining of HL-60/S4 0 using anti-nuclear pore complex (Mab 414), without sucrose dehydration (Top Row), compared to S4 0 cells exposed to 30 minutes of sucrose dehydration (Bottom Row). Note the congelation of interphase chromatin treated with sucrose, and the increased disorder of NPCs. All images are deconvolved. The magnification bar represents 10 μm.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Immunostaining of HL-60/S4 0 using anti-nuclear pore complex (Mab 414), without sucrose dehydration (Top Row), compared to S4 0 cells exposed to 30 minutes of sucrose dehydration (Bottom Row). Note the congelation of interphase chromatin treated with sucrose, and the increased disorder of NPCs. All images are deconvolved. The magnification bar represents 10 μm.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Immunostaining

Immunostaining of an undifferentiated HL-60/S4 0 cell and an undifferentiated HL-60/sh1 0 cell with anti-nuclear pore complex (Mab 414) (Top Row), compared to the identical DAPI stained regions (Bottom Row). The first and third columns display tangential views of the cell nuclei; the second and fourth columns display mid-sections of the stained nuclei. All images are deconvolved. The magnification bar represents 10 μm.

Journal: bioRxiv

Article Title: Nuclear Pore Complexes in Various States of HL-60/S4 Cells

doi: 10.64898/2026.01.09.697371

Figure Lengend Snippet: Immunostaining of an undifferentiated HL-60/S4 0 cell and an undifferentiated HL-60/sh1 0 cell with anti-nuclear pore complex (Mab 414) (Top Row), compared to the identical DAPI stained regions (Bottom Row). The first and third columns display tangential views of the cell nuclei; the second and fourth columns display mid-sections of the stained nuclei. All images are deconvolved. The magnification bar represents 10 μm.

Article Snippet: HL-60/S4 cells can be purchased from ATCC (CRL-3306).

Techniques: Immunostaining, Staining

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