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hfc biosensors (gatorbio, palo alto, ca, usa)  (Gator Bio Inc)


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    Gator Bio Inc hfc biosensors (gatorbio, palo alto, ca, usa)
    Hfc Biosensors (Gatorbio, Palo Alto, Ca, Usa), supplied by Gator Bio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hfc+biosensor/hfc+biosensors/pmc11448423-245-2-4
    Average 90 stars, based on 1 article reviews
    hfc biosensors (gatorbio, palo alto, ca, usa) - by Bioz Stars, 2026-11
    90/100 stars

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    Binding Assay:

    Article Title: FZ-AD005, a Novel DLL3-Targeted Antibody–Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models
    Article Snippet: GatorPlus (Gator Bio) was used for the human DLL3 (ACROBiosystems, DL3-H52), FcγRI (Rhingen, QRE-133), FcγRIIa (Rhingen, QRE-135-A), FcγIIIa (Rhingen, QRE-137-A), and FcRn (ACROBiosystems, FCM H82W7) binding kinetics assays. .. Fab binding assay was first performed by capturing 1 μg/mL of FZ-AD038 or FZ-AD005 using a HFC biosensor (Gator, 160003). ..

    Article Title: FZ-AD005, A Novel DLL3-Targeted Antibody-drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models
    Article Snippet: Delta-like ligand 3 (DLL3) is overexpressed in small-cell lung cancer (SCLC) and has been considered an attractive target for SCLC therapy.. Rovalpituzumab tesirine (Rova-T) was the first DLL3-targeted antibody-drug conjugate (ADC) to enter clinical studies.. However, serious adverse events limited progress in the treatment of SCLC with Rova-T.



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    Measurement of binding constant (K D ), association constant (K on ) and dissociation constant (K off ) of anti-CD16 antibody clones by BLI. (a) anti-CD16a clones in IgG1 format; (b) anti-CD16a in fab format, in the absence or presence of 10 mg/mL of hIgG; (c) anti-CD16a in monovalent BiKE format; (d) anti-CD16a in the bivalent IgG-like BsAb format; (e) anti-CD16a in the bivalent BiKE-IgG4 format. <t>An</t> <t>anti-HIgG</t> Fc biosensor was used to capture Fc-containing antibodies (a, d and e) or streptavidin biosensor was used to capture biotinylated CD16a (b and c). Non-biotinylated CD16a (a, d and e), CD16b (a), fab (b) or BiKE (c) at serial dilutions was added to the biosensors, in the presence (b) or absence (a, b, c, d and e) of 10 mg/mL of hIgG.
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    Image Search Results


    Measurement of binding constant (K D ), association constant (K on ) and dissociation constant (K off ) of anti-CD16 antibody clones by BLI. (a) anti-CD16a clones in IgG1 format; (b) anti-CD16a in fab format, in the absence or presence of 10 mg/mL of hIgG; (c) anti-CD16a in monovalent BiKE format; (d) anti-CD16a in the bivalent IgG-like BsAb format; (e) anti-CD16a in the bivalent BiKE-IgG4 format. An anti-HIgG Fc biosensor was used to capture Fc-containing antibodies (a, d and e) or streptavidin biosensor was used to capture biotinylated CD16a (b and c). Non-biotinylated CD16a (a, d and e), CD16b (a), fab (b) or BiKE (c) at serial dilutions was added to the biosensors, in the presence (b) or absence (a, b, c, d and e) of 10 mg/mL of hIgG.

    Journal: mAbs

    Article Title: Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers

    doi: 10.1080/19420862.2024.2381261

    Figure Lengend Snippet: Measurement of binding constant (K D ), association constant (K on ) and dissociation constant (K off ) of anti-CD16 antibody clones by BLI. (a) anti-CD16a clones in IgG1 format; (b) anti-CD16a in fab format, in the absence or presence of 10 mg/mL of hIgG; (c) anti-CD16a in monovalent BiKE format; (d) anti-CD16a in the bivalent IgG-like BsAb format; (e) anti-CD16a in the bivalent BiKE-IgG4 format. An anti-HIgG Fc biosensor was used to capture Fc-containing antibodies (a, d and e) or streptavidin biosensor was used to capture biotinylated CD16a (b and c). Non-biotinylated CD16a (a, d and e), CD16b (a), fab (b) or BiKE (c) at serial dilutions was added to the biosensors, in the presence (b) or absence (a, b, c, d and e) of 10 mg/mL of hIgG.

    Article Snippet: A Gator Anti-HIgG Fc biosensor (Cat.: PL168–160003) was used to capture IgG1 antibody or IgG4 bivalent engager to detect its binding to CD16, or a streptavidin biosensor (Cat.: 160002) to capture the biotinylated CD16 antigen for detection of binding to monovalent antibodies, e.g., Fab, monovalent BiKE.

    Techniques: Binding Assay, Clone Assay