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Proposed cellular uptake, intracellular trafficking, and autophagy behaviors of DOX-loaded glycopolymer nanomicelles in Human Glioblastoma Carcinoma cells

Journal: Journal of Materials Science. Materials in Medicine

Article Title: Glycopolymer nanomicelles: pH-responsive drug delivery, endocytosis pathway, autophagy behavior, and the effect of autophagy inhibitors

doi: 10.1007/s10856-024-06837-4

Figure Lengend Snippet: Proposed cellular uptake, intracellular trafficking, and autophagy behaviors of DOX-loaded glycopolymer nanomicelles in Human Glioblastoma Carcinoma cells

Article Snippet: Taken together, this work provided a preliminary understanding of the intracellular drug delivery properties of glycopolymer micelles and demonstrated the effect of different autophagy inhibitors, which may benefit the innovation of “autophagy regulator-combined nanotherapeutics” towards high performance tumor chemotherapy.

Techniques:

Top: Preparation of DOX-loaded glycopolymer micelles with pH-responsive manners; Bottom: ( A ) DLS characterization of the hydrodynamic particle size and distributions of the blank and DOX-loaded micelles (inset: TEM image of the DOX-loaded micelles, scale bar: 200 nm); ( B ) time- dependent colloidal stability of the DOX-loaded micelles in PBS buffer (pH 7.4, 10 mM) at 37 °C

Journal: Journal of Materials Science. Materials in Medicine

Article Title: Glycopolymer nanomicelles: pH-responsive drug delivery, endocytosis pathway, autophagy behavior, and the effect of autophagy inhibitors

doi: 10.1007/s10856-024-06837-4

Figure Lengend Snippet: Top: Preparation of DOX-loaded glycopolymer micelles with pH-responsive manners; Bottom: ( A ) DLS characterization of the hydrodynamic particle size and distributions of the blank and DOX-loaded micelles (inset: TEM image of the DOX-loaded micelles, scale bar: 200 nm); ( B ) time- dependent colloidal stability of the DOX-loaded micelles in PBS buffer (pH 7.4, 10 mM) at 37 °C

Article Snippet: Taken together, this work provided a preliminary understanding of the intracellular drug delivery properties of glycopolymer micelles and demonstrated the effect of different autophagy inhibitors, which may benefit the innovation of “autophagy regulator-combined nanotherapeutics” towards high performance tumor chemotherapy.

Techniques: