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Verlag GmbH
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Feto Maternal and GenetYX Center
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BioMimetic Therapeutics
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BioMimetic Therapeutics
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Lectinity Holding Inc
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Verlag GmbH
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NanoVector
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Lectinity Holding Inc
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Image Search Results
Journal: Chemical Science
Article Title: Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN
doi: 10.1039/c7sc01515a
Figure Lengend Snippet: Representative chemical structures of the mannose glycopolymers. R = Br in the initiator structure.
Article Snippet: Importantly, IL-10 levels rise and IL-12 levels fall in response to the
Techniques:
Journal: Chemical Science
Article Title: Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN
doi: 10.1039/c7sc01515a
Figure Lengend Snippet: Concentration-dependent glycopolymer binding to DCs. Dendritic cells were labeled with the indicated concentration of FITC-labeled glycopolymers/glycoprotein (Panel A – Linear P1 ; Panel B – 5-arm star P2 ; Panel C – 8-arm star P3 ; and Panel D – gp120) and analyzed by flow cytometry. The data are representative of one of 3 donors.
Article Snippet: Importantly, IL-10 levels rise and IL-12 levels fall in response to the
Techniques: Concentration Assay, Binding Assay, Labeling, Flow Cytometry
Journal: Chemical Science
Article Title: Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN
doi: 10.1039/c7sc01515a
Figure Lengend Snippet: Effects of glycopolymers on cytokine secretion by activated DCs. Cells were incubated with GPs before activation with LPS and IFN-γ and multiplex cytokine assay. IL-10 secretion was significantly increased in DC cultures from 4 donors incubated with 8-arm star P3 and 5-arm star P2 GPs at 10 μg ml –1 compared with controls, but not with linear GP P1 (Panel A). IL-12p70 secretion was significantly decreased compared to controls in cells exposed to increasing concentrations of linear GP P1 (Panel B), 5-arm star GP P2 (Panel C) and 8-arm star GP P3 (Panel D) (all P values calculated from paired t -tests).
Article Snippet: Importantly, IL-10 levels rise and IL-12 levels fall in response to the
Techniques: Incubation, Activation Assay, Multiplex Assay, Cytokine Assay