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sr 95531 hydrobromide  (Tocris)


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    Tocris sr 95531 hydrobromide
    Sr 95531 Hydrobromide, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 599 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gabazine+hydrobromide/SR+95531+hydrobromide/bio_rxiv__64898__2026__10__15__759497-254-37-43
    Average 96 stars, based on 599 article reviews
    sr 95531 hydrobromide - by Bioz Stars, 2026-11
    96/100 stars

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    Sterility:

    Article Title: The Involvement of Hypothalamic Sleep Pathways in General Anesthesia: Testing the Hypothesis Using the GABAA Receptor 3N265M Knock-In Mouse
    Article Snippet: .. Pentobarbital sodium salt, dexmedetomidine (Dex; donated by Orion Pharmaceuticals), muscimol hydrobromide, chloral hydrate, and gabazine hydrobromide (SR-95531, Tocris) were prepared in sterile saline (0.9% NaCl w/v) solution. .. Halothane (Fluothane, Zeneca) and isoflurane (Aerrane, Baxter) were administered through a TEC vaporizer (Ohmeda; BOC Healthcare) and anesthesia machine (Ohmeda; BOC Healthcare).

    Saline:

    Article Title: The Involvement of Hypothalamic Sleep Pathways in General Anesthesia: Testing the Hypothesis Using the GABAA Receptor 3N265M Knock-In Mouse
    Article Snippet: .. Pentobarbital sodium salt, dexmedetomidine (Dex; donated by Orion Pharmaceuticals), muscimol hydrobromide, chloral hydrate, and gabazine hydrobromide (SR-95531, Tocris) were prepared in sterile saline (0.9% NaCl w/v) solution. .. Halothane (Fluothane, Zeneca) and isoflurane (Aerrane, Baxter) were administered through a TEC vaporizer (Ohmeda; BOC Healthcare) and anesthesia machine (Ohmeda; BOC Healthcare).

    Multiple Displacement Amplification:

    Article Title: Population patch-clamp electrophysiology analysis of recombinant GABAA alpha1beta3gamma2 channels expressed in HEK-293 cells.
    Article Snippet: .. Compounds were obtained from the following sources: GABA, diazepam, pentobarbital Na, and bicuculline methiodide (all Sigma-Aldrich); zolpidem, propofol, chlormethiazole hydrochloride, gabazine hydrobromide, and picrotoxin (all Tocris, Ellisville, MO); tracazolate succinate (Research Biomedicals St. Louis, MO); and etomidate (MDA Chemicals, Lancaster, UK). ..

    other:

    Article Title: Intralaminar and Interlaminar Activity within the Rodent Superior Colliculus Visualized with Voltage Imaging
    Article Snippet: Gabazine hydrobromide (SR-95531) was obtained from either Tocris Bioscience or Sigma-Aldrich.



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    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
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    sr95531  (Tocris)
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    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
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    95531 hydrobromide  (Tocris)
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    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    95531 Hydrobromide, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    sr95531 hydrobromide  (Tocris)
    96
    Tocris sr95531 hydrobromide
    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    Sr95531 Hydrobromide, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    95531 hydrobromide gabazine  (Tocris)
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    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of <t>gabazine</t> (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.
    95531 Hydrobromide Gabazine, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of gabazine (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.

    Journal: bioRxiv

    Article Title: P2X7 receptor-mediated astrocytic atrophy in the hippocampus of mice after status epilepticus

    doi: 10.64898/2026.04.16.718853

    Figure Lengend Snippet: Spontaneous postsynaptic currents (sPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) of hippocampal CA1 pyramidal neurons; effects of Bz-ATP. sEPSCs were recorded in the continuous presence of gabazine (10 µM). Bz-ATP (300 µM) effects on the amplitude and frequency of the spontaneous currents in low X 2+ aCSF. (A) Representative recordings or sPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (B) Representative, averaged sPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (C) Mean±S.E.M. sPSC amplitudes (left panel) and mean±S.E.M. frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (D) Percentage changes of sPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test), as calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells. (E) Representative recordings or sEPSCs before, during, and after superfusion with Bz-ATP for 5 min, as well as after washing out this agonist. (F) Representative, averaged sEPSC amplitude before, during and after a 5 min superfusion with Bz-ATP. (G) Mean±S.E.M. sEPSC amplitudes (left panel) and mean±S.E.M. sEPSC frequencies (right panel) calculated from 11 cells. P>0.05 all; one-way ANOVA, followed by the Tukey’s test in both panels. (H) Percentage changes of sEPSC amplitudes (left panel; P>0.05 all, Kruskal-Wallis ANOVA, followed by the Dunn’s test) and frequency (right panel; P>0.05 all; one-way ANOVA, followed by the Tukey’s test; §§ P<0.01; Kruskal-Wallis ANOVA, followed by the Dunn’s test) were calculated relative to the pre-Bz-ATP amplitude and frequency set at 100%, and shown as mean±S.E.M. values of 11 cells.

    Article Snippet: The drugs used were the following: JNJ-47965567, gabazine hydrobromide (Tocris Biosciences, Bristol, UK); kainic acid hydrate (MedChem Express, Monmouth Junction, NJ, USA); diazepam (Shanghai Xudong Haipu Pharmaceutical Co., Shanghai, China).

    Techniques: