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alk5-fc  (R&D Systems)


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    R&D Systems alk5-fc
    Alk5 Fc, supplied by R&D Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fc+alk5/alk5+fc/us11813315-1180-9-10
    Average 90 stars, based on 1 article reviews
    alk5-fc - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    other:

    Article Title: Structural basis for potency differences between GDF8 and GDF11
    Article Snippet: Purchased proteins were as follows: mature GDF8 (R&D Systems; Cat. no. 788-G8-CF and PeproTech; Cat. no. 120-00), mature GDF11 (R&D Systems; Cat. no. 1958-GD-010-CF and PeproTech (Cat. no. 120-11); Fc-ALK5 (R&D Systems; Cat. no. 3025-BR/CF), Fc-ActRIIB (R&D Systems; Cat. no. 339-RB/CF).



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    Image Search Results


    TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and IgG were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.

    Journal: Scientific Reports

    Article Title: Interleukin 37 promotes angiogenesis through TGF-β signaling

    doi: 10.1038/s41598-017-06124-z

    Figure Lengend Snippet: TGF-β1 enhanced the binding of IL-37 to HUVECs. ( A ) TGF-β1 facilitates the binding of IL-37 to HUVECs. HUVECs were incubated with 1 μM biot-IL-37 with/without indicated concentrations of TGF-β1. Bound biot-IL-37 was assessed by flow cytometry. Gray histograms indicated unlabeled cells. The mean fluorescence intensity (MFI) of bound IL-37 was quantified ( n = 4). ( B ) ALK-1 mediates TGF-β-facilitated binding of IL-37 to HUVECs. Flow cytometry of HUVECs incubated with indicated cytokines or antibodies. Biot-IL-37 and TGF-β1 were used at 1 μM. Anti-ALK1 antibody (α-ALK1) and IgG were used at 10 μg/mL. ( C ) Control and ALK1 siRNA-transfected HUVECs were incubated with indicated proteins or antibodies (10 μg/mL). Biotinylated IL-37 (biot-IL-37) and recombinant TGF-β were used at 1 μM. Data are presented as mean ± SEM. ** P < 0.01, *** P < 0.001.

    Article Snippet: Recombinant soluble chimeric protein containing the ectodomain of human ALK1 conjugated with IgG Fc (ALK1-Fc), chimeric protein containing the ectodomain of human ALK5 conjugated with IgG Fc (ALK5-Fc) and chimeric protein containing ectodomain of human TβRII conjugated with IgG Fc (TβRII-Fc) were purchased from Sinobiological (Beijing, China).

    Techniques: Binding Assay, Incubation, Flow Cytometry, Fluorescence, Transfection, Recombinant