Journal: Turkish Journal of Obstetrics and Gynecology
Article Title: Evaluation of the diagnostic utility of MCAM-1 (CD146) in a group of common gynecological cancers: A case-control study
doi: 10.4274/tjod.galenos.2024.38265
Figure Lengend Snippet: Photomicrographs ‘a’ (at low power) & ‘b’ (at high power with a mean MVD of 62.5 per mm 2 per mm 2 ) show a case of WDSCC, with an IRS of 5 i.e., Positive for CD146 expression; whereas ‘c’ (at low power) & ‘d’ (at high power with a mean MVD of 133.312 per mm 2 ) show a case of endocervical adenocarcinoma, with an IRS of 6 i.e., Positive for CD146 expression Photomicrographs ‘e’ (at low power) & ‘f’ (at high power with mean MVD of 95.81 per mm2) showing a case of LGEC with an IRS of 3 i.e., negative for MCAM expression whereas ‘g’ (at low power) & ‘h’ (at high power with a mean MVD of 147.87 per mm2) show a case of HGEC with an IRS of 6 i.e., positive for CD146 expression. Photomicrographs ‘i’ (at low power) & ‘j’ (at high power with a mean MVD of 45.81 per mm2) showing a case of APST with an IRS of 4 i.e., negative for CD146 expression; whereas ‘k’ (at low power) & ‘l’ (at high power with a mean MVD of 197.87 per mm2) showing a case of MOC with an IRS of 6 i.e., positive for CD146 expression. Photomicrographs ‘m’ (at low power) & ‘n’ (at high power with a mean MVD of 231.25 per mm2) show a case of squamous carcinoma of the vulva with an IRS of 6 i.e., is positive for CD146 expression. Photomicrograph ‘o’ (at low power) & ‘p’(at high power with a mean MVD of 133.312 per mm2) showing a case of STIC with an IRS of 3 i.e. Negative for CD146 expression MOC: Mucinous ovarian carcinoma, MVD: Microvascular density, IRS: Immunoreactivity score, HGEC: High grade endometrial carcinoma, APST: Atypical proliferative serous tumour, STIC: Serous tubal intraepithelial carcinoma
Article Snippet: Primary antibody CD146 [Biogenex, Anti Human CD146 (clone EP54)] was applied, followed by washing and incubation with Polyexcel target binder and Polyexcel PolyHRP (horse radish Peroxidase).
Techniques: Expressing