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ds2 isolated voltage stimulator  (Digitimer Ltd)

 
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    Digitimer Ltd ds2 isolated voltage stimulator
    Ds2 Isolated Voltage Stimulator, supplied by Digitimer Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ds2+stimulator/ds2a+isolated+stimulator/10__1113_slash_jp283600-168-22-26
    Average 90 stars, based on 1 article reviews
    ds2 isolated voltage stimulator - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    other:

    Article Title: Sphingolipids regulate neuromuscular synapse structure and function in Drosophila.
    Article Snippet: Segmental nerves were aspirated into a micropipette with a heat-polished tip, aperture 10–15 mm, and stimulated with trains of four or five (TOF) supramaximal pulses (nominally 10V, 0.1–0.2 ms duration; interval 50 ms, that is, 20 Hz; programmed in Clampex) triggering a DS2 stimulator (Digitimer, Welywn Garden City, UK).

    Article Title: Antagonistic postsynaptic and presynaptic actions of cyclohexanol on neuromuscular synaptic transmission and function
    Article Snippet: Nerve stimuli (nominally up to 10 V, 0.1–0.2ms duration, 2–20 Hz) were delivered via a DS2 stimulator (Digitimer, Welwyn Garden City, UK) triggered by the PowerLab 26T interface (ADInstruments).

    Article Title: Sphingolipids regulate neuromuscular synapse structure and function in Drosophila
    Article Snippet: Segmental nerves were aspirated into a micropipette with a heat‐polished tip, aperture 10–15 μm, and stimulated with trains of four or five (TOF) supramaximal pulses (nominally 10V, 0.1–0.2 ms duration; interval 50 ms, that is, 20 Hz; programmed in Clampex) triggering a DS2 stimulator (Digitimer, Welywn Garden City, UK).

    Article Title: "Calcium bombs" as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions.
    Article Snippet: Nerve stimuli (0.1–0.2 ms duration, nominally up to 10 V) were delivered via a DS2 stimulator (Digitimer, Welwyn Garden City, United Kingdom).

    Article Title: Antagonistic postsynaptic and presynaptic actions of cyclohexanol on neuromuscular synaptic transmission and function
    Article Snippet: EPPs and EPCswere evoked by connecting the suction electrode to a DS2 stimulator and triggered using Spike2, WinWCP4.2, Clampex, or Digitimer D4030 programs.

    Article Title: Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle.
    Article Snippet: Nerve stimuli (nominally up to 10 V, 0.1–0.2 ms duration, 2–20 Hz) were delivered via a DS2 stimulator (Digitimer, Welwyn Garden City, UK) triggered by a Powerlab 26T interface (AD Instruments).

    Article Title: Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin
    Article Snippet: The proximal tendon was attached to an ML102 force transducer (AD Instruments, Oxford, UK) and the tibial nerve was aspirated into a capillary glass-tipped suction electrode connected to a DS2 Stimulator (Digitimer, Welwyn Garden City, UK), then stimulated with pulses 0.1–0.2 ms in duration and nominally up to 10 V amplitude at frequencies of 0.5–50 Hz.

    Article Title: Impaired neuromuscular function by conjoint actions of organophosphorus insecticide metabolites omethoate and cyclohexanol with implications for treatment of respiratory failure.
    Article Snippet: Nerve stimuli (0.1–0.2ms duration, nominally up to 10 V) were delivered via a DS2 stimulator (Digitimer, Welwyn Garden City, UK) triggered by the Powerlab 26 T interface.



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    Four groups of neurones are distinguished from their response to food odour. From ( A ) to ( D ) top: all neurone activity before ( left ) and during ( right ) food odour <t>stimulation.</t> Activity is measured as number of spikes per 250 ms and averaged over 2 s before and 2 s during odour stimulation. Bottom: illustration of the response of a single neurone from the same group. Black bar, odour stimulation. Top trace is respiration, bottom trace is single unit recording. X axis in seconds (S). ( A ): 23 neurones increased their activity during food odour stimulation. ( B ): 10 neurones decreased their activity upon food odour stimulation. ( C ): these 8 neurones did not display a change in their activity but became rhythmic in phase with the respiratory cycle during odour stimulation. ( D ): 53 neurones didn’t respond to food odour stimulation.
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    Four groups of neurones are distinguished from their response to food odour. From ( A ) to ( D ) top: all neurone activity before ( left ) and during ( right ) food odour stimulation. Activity is measured as number of spikes per 250 ms and averaged over 2 s before and 2 s during odour stimulation. Bottom: illustration of the response of a single neurone from the same group. Black bar, odour stimulation. Top trace is respiration, bottom trace is single unit recording. X axis in seconds (S). ( A ): 23 neurones increased their activity during food odour stimulation. ( B ): 10 neurones decreased their activity upon food odour stimulation. ( C ): these 8 neurones did not display a change in their activity but became rhythmic in phase with the respiratory cycle during odour stimulation. ( D ): 53 neurones didn’t respond to food odour stimulation.

    Journal: Biomedicines

    Article Title: Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

    doi: 10.3390/biomedicines10051126

    Figure Lengend Snippet: Four groups of neurones are distinguished from their response to food odour. From ( A ) to ( D ) top: all neurone activity before ( left ) and during ( right ) food odour stimulation. Activity is measured as number of spikes per 250 ms and averaged over 2 s before and 2 s during odour stimulation. Bottom: illustration of the response of a single neurone from the same group. Black bar, odour stimulation. Top trace is respiration, bottom trace is single unit recording. X axis in seconds (S). ( A ): 23 neurones increased their activity during food odour stimulation. ( B ): 10 neurones decreased their activity upon food odour stimulation. ( C ): these 8 neurones did not display a change in their activity but became rhythmic in phase with the respiratory cycle during odour stimulation. ( D ): 53 neurones didn’t respond to food odour stimulation.

    Article Snippet: They were connected to an insulated stimulation device (model DS2, Digitimer Ltd., Welwyn Garden City, UK) delivering square wave pulses.

    Techniques: Activity Assay, Single-unit Recording

    Relation between spontaneous activity of neurones and food odour evoked activation. For those 23 food odour excited neurones of A, each point displays the percent increased activity upon food odour stimulation (y-axis) plotted versus the mean spontaneous activity (x-axis). There is a significant correlation between the 2 variables (Spearman r = −0.5744, p = 0.0041).

    Journal: Biomedicines

    Article Title: Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

    doi: 10.3390/biomedicines10051126

    Figure Lengend Snippet: Relation between spontaneous activity of neurones and food odour evoked activation. For those 23 food odour excited neurones of A, each point displays the percent increased activity upon food odour stimulation (y-axis) plotted versus the mean spontaneous activity (x-axis). There is a significant correlation between the 2 variables (Spearman r = −0.5744, p = 0.0041).

    Article Snippet: They were connected to an insulated stimulation device (model DS2, Digitimer Ltd., Welwyn Garden City, UK) delivering square wave pulses.

    Techniques: Activity Assay, Activation Assay

    Effects of food odour stimulation on LFP recordings. ( Left ) In a first test, we observed that odour released from 3 g and 10 g of freshly crushed food pellets increased power in the beta-band frequency (15–40 Hz, power ratio: [power during the 2 s of stimulation/power for 2 s before the stimulation]) as compared to no odour (empty container) ( n = 9 rats). A second test of odour stimulation ( right ) performed 5 min later, still elicited a power increase with 3 g and 10 g food odour stimulation, although of lesser amplitude. Empty container different from 3 g and 10 g, * p < 0.05.

    Journal: Biomedicines

    Article Title: Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

    doi: 10.3390/biomedicines10051126

    Figure Lengend Snippet: Effects of food odour stimulation on LFP recordings. ( Left ) In a first test, we observed that odour released from 3 g and 10 g of freshly crushed food pellets increased power in the beta-band frequency (15–40 Hz, power ratio: [power during the 2 s of stimulation/power for 2 s before the stimulation]) as compared to no odour (empty container) ( n = 9 rats). A second test of odour stimulation ( right ) performed 5 min later, still elicited a power increase with 3 g and 10 g food odour stimulation, although of lesser amplitude. Empty container different from 3 g and 10 g, * p < 0.05.

    Article Snippet: They were connected to an insulated stimulation device (model DS2, Digitimer Ltd., Welwyn Garden City, UK) delivering square wave pulses.

    Techniques:

    Simultaneous recordings of multiunit activity and local field potentials in the ventral striatum. The raw electrophysiological signal (( A ), 1 Hz–10 kHz) was filtered to provide multiunit activity (( C ), high pass > 500 Hz) and LFP in the beta-band frequency (( D ), bandpass: 15–40 Hz). ( E ) represents the time-frequency plot of ( D ) channel (yellow-orange colours: higher power). Black horizontal bar: 2 s of food odour stimulation. ( B ): respiration. Food odour stimulation elicited increased neuronal activity, which became rhythmic [( C )], greater amplitude and frequency of the LFP signal ( A , D ), and increased power in the beta-band frequency [( E )]. mV millivolt; AU arbitrary units; Hz: hertz, s: seconds.

    Journal: Biomedicines

    Article Title: Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

    doi: 10.3390/biomedicines10051126

    Figure Lengend Snippet: Simultaneous recordings of multiunit activity and local field potentials in the ventral striatum. The raw electrophysiological signal (( A ), 1 Hz–10 kHz) was filtered to provide multiunit activity (( C ), high pass > 500 Hz) and LFP in the beta-band frequency (( D ), bandpass: 15–40 Hz). ( E ) represents the time-frequency plot of ( D ) channel (yellow-orange colours: higher power). Black horizontal bar: 2 s of food odour stimulation. ( B ): respiration. Food odour stimulation elicited increased neuronal activity, which became rhythmic [( C )], greater amplitude and frequency of the LFP signal ( A , D ), and increased power in the beta-band frequency [( E )]. mV millivolt; AU arbitrary units; Hz: hertz, s: seconds.

    Article Snippet: They were connected to an insulated stimulation device (model DS2, Digitimer Ltd., Welwyn Garden City, UK) delivering square wave pulses.

    Techniques: Activity Assay