Journal: Journal of Vascular Surgery Cases, Innovations and Techniques

Article Title: Intentional subintimal loop technique for orientation recovery in superficial femoral artery chronic total occlusion with pedal-origin controlled antegrade and retrograde subintimal tracking

doi: 10.1016/j.jvscit.2026.102251

Figure Lengend Snippet: Pedal-origin controlled antegrade and retrograde subintimal tracking (CART) procedure. (A) After unsuccessful proximal re-entry into the true lumen, a retrograde approach via pedal access was selected. (B) A 4.0-mm balloon was advanced over the retrograde guidewire from the pedal artery and inflated at the popliteal artery to create a controlled subintimal connection (CART maneuver). (C) After balloon inflation, the antegrade guidewire was successfully advanced into the true lumen of the distal target vessel. (D) A drug-coated balloon was subsequently inflated along the previously occluded segment of the superficial femoral artery (SFA). (E) Final digital subtraction angiography demonstrates restored antegrade flow with satisfactory distal runoff through the revascularized SFA.

Article Snippet: The occluded SFA segment was subsequently treated with a drug-coated balloon (5 mm × 200 mm Ranger DCB balloon; Boston Scientific) ( , D ), which achieved satisfactory final angiographic results with good distal runoff ( , E ).

Techniques:

Journal: iScience

Article Title: A comprehensive pharmacological survey across heterogeneous patient-derived glioblastoma stem cell models

doi: 10.1016/j.isci.2026.115839

Figure Lengend Snippet: High-content image analysis/dimensionality reduction of drug screening data (A–C) Representative data of high content analysis across six GSC lines and three compound libraries (LOPAC, (A) Prestwick FDA (B) and C3L, (C) by 3D principal component analysis (PCA) (median aggregation to well level, n = 6 fields of view). DMSO controls circled in Black ( n = 48 per plate). Magnitude of vector co-ordinates for PC1, 2, 3 (sized by PC4) are indicated by color, red-pink (strong –PC1, –PC2), blue (strong +PC3, –PC2), green (strong +PC1 +PC2), yellow/gray (weaker phenotypes). PC1-4 factor loadings are given (%). Factor loadings are provided in . (D–F) Phenotypic distance of screened compounds (LOPAC, D, Prestwick FDA, E and C3L, F). We employed 20 principal components (>60% explained variance) to compute a phenotypic distance (Euclidean) for each compound. The corresponding p values are plotted against cell survival (normalized z scores, y axis). Legend indicates strength of –log 10 [ p value] distribution (five bins, red = maximal effect, reducing to gray where at = arbitrary threshold). Several example hits are labeled.

Article Snippet: Prestwick FDA approved Drug Library , Prestwick Chemical , https://www.prestwickchemical.com/screening-libraries/prestwick-chemical-library/.

Techniques: Drug discovery, High Content Screening, Plasmid Preparation, Labeling