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dose response curve  (GraphPad Software Inc)


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    GraphPad Software Inc dose response curve
    Dose Response Curve, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 99/100, based on 147798 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dose-response+curves/Prism+8/pm42839251-101-13-16
    Average 99 stars, based on 147798 article reviews
    dose response curve - by Bioz Stars, 2026-11
    99/100 stars

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    Construct:

    Article Title: An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.
    Article Snippet: Municipal wastewater treatment plants (WWTPs) release endocrine disrupting chemicals (EDCs) which can impact aquatic species’ reproduction (e.g., decrease fecundity).. As bioassays can quantify the cumulative effect of mixtures, such as effluents, this study proposes a two-Tier bioassay-based approach to assess EDCs in WWTP effluents.. The first Tier is composed of the human receptor transactivation assay for estrogen (hERα) and androgen (hAR), and the Tier 2 comprises an abbreviated 7-day fish short-term reproduction assay (FSTRA; OECD TG 229) in fathead minnow (Pimephales promelas).

    Article Title: Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models
    Article Snippet: The IC 50 values were calculated using dose–response curves and GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

    Article Title: Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice.
    Article Snippet: Mean temperature Δ across all timepoints post-injection was used to generate dose-response curves (GraphPad Prism 10: agonist vs. response, variable slope, Hill slope > − 5 or = − 5 (for etonitazene and (5)).

    Article Title: Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
    Article Snippet: Data points were then visualized using dose–response curves from PRISM v7.01 (GraphPad Software, La Jolla, CA, USA).

    Article Title: Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease.
    Article Snippet: The global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) urges the development of new antiviral agents with broad coronavirus coverage.. Due to its key role in viral evasion from the host innate immune response, the coronavirus Nsp15 uridine-specific endoribonuclease (EndoU) is of high interest as a drug target.. Considering that the isatin scaffold is well-known for its versatile pharmacological properties, we synthesized and evaluated a series of compounds carrying an isatin core.

    Article Title: Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR
    Article Snippet: The dose-response curves were constructed by plotting the logarithmic scale of the concentrations and their corresponding %Inhibition values (GraphPad Prism 10; GraphPad Software).

    Article Title: Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
    Article Snippet: A one-way or two-way ANOVA, Tukey's multiple comparisons test (for multi-group comparisons), mixed-effects models, repeated measurements, dose-response curves, and Student's t-test were the bases for the statistical assessment, which was carried out using GraphPad 9.5.1.

    Article Title: Development and experimental validation of a machine learning model for the prediction of new antimalarials
    Article Snippet: The IC 50 of each compound was calculated by plotting sigmoidal dose-response curves in GraphPad Prism v 8.0.0. (GraphPad Software Inc., La Jolla, CA, USA).

    Inhibition:

    Article Title: An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.
    Article Snippet: Municipal wastewater treatment plants (WWTPs) release endocrine disrupting chemicals (EDCs) which can impact aquatic species’ reproduction (e.g., decrease fecundity).. As bioassays can quantify the cumulative effect of mixtures, such as effluents, this study proposes a two-Tier bioassay-based approach to assess EDCs in WWTP effluents.. The first Tier is composed of the human receptor transactivation assay for estrogen (hERα) and androgen (hAR), and the Tier 2 comprises an abbreviated 7-day fish short-term reproduction assay (FSTRA; OECD TG 229) in fathead minnow (Pimephales promelas).

    Article Title: Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models
    Article Snippet: The IC 50 values were calculated using dose–response curves and GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

    Article Title: Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice.
    Article Snippet: Mean temperature Δ across all timepoints post-injection was used to generate dose-response curves (GraphPad Prism 10: agonist vs. response, variable slope, Hill slope > − 5 or = − 5 (for etonitazene and (5)).

    Article Title: Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
    Article Snippet: Data points were then visualized using dose–response curves from PRISM v7.01 (GraphPad Software, La Jolla, CA, USA).

    Article Title: Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease.
    Article Snippet: The global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) urges the development of new antiviral agents with broad coronavirus coverage.. Due to its key role in viral evasion from the host innate immune response, the coronavirus Nsp15 uridine-specific endoribonuclease (EndoU) is of high interest as a drug target.. Considering that the isatin scaffold is well-known for its versatile pharmacological properties, we synthesized and evaluated a series of compounds carrying an isatin core.

    Article Title: Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR
    Article Snippet: The dose-response curves were constructed by plotting the logarithmic scale of the concentrations and their corresponding %Inhibition values (GraphPad Prism 10; GraphPad Software).

    Article Title: Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
    Article Snippet: A one-way or two-way ANOVA, Tukey's multiple comparisons test (for multi-group comparisons), mixed-effects models, repeated measurements, dose-response curves, and Student's t-test were the bases for the statistical assessment, which was carried out using GraphPad 9.5.1.

    Article Title: Development and experimental validation of a machine learning model for the prediction of new antimalarials
    Article Snippet: The IC 50 of each compound was calculated by plotting sigmoidal dose-response curves in GraphPad Prism v 8.0.0. (GraphPad Software Inc., La Jolla, CA, USA).

    Activity Assay:

    Article Title: An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.
    Article Snippet: Municipal wastewater treatment plants (WWTPs) release endocrine disrupting chemicals (EDCs) which can impact aquatic species’ reproduction (e.g., decrease fecundity).. As bioassays can quantify the cumulative effect of mixtures, such as effluents, this study proposes a two-Tier bioassay-based approach to assess EDCs in WWTP effluents.. The first Tier is composed of the human receptor transactivation assay for estrogen (hERα) and androgen (hAR), and the Tier 2 comprises an abbreviated 7-day fish short-term reproduction assay (FSTRA; OECD TG 229) in fathead minnow (Pimephales promelas).

    Article Title: Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models
    Article Snippet: The IC 50 values were calculated using dose–response curves and GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

    Article Title: Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice.
    Article Snippet: Mean temperature Δ across all timepoints post-injection was used to generate dose-response curves (GraphPad Prism 10: agonist vs. response, variable slope, Hill slope > − 5 or = − 5 (for etonitazene and (5)).

    Article Title: Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
    Article Snippet: Data points were then visualized using dose–response curves from PRISM v7.01 (GraphPad Software, La Jolla, CA, USA).

    Article Title: Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease.
    Article Snippet: The global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) urges the development of new antiviral agents with broad coronavirus coverage.. Due to its key role in viral evasion from the host innate immune response, the coronavirus Nsp15 uridine-specific endoribonuclease (EndoU) is of high interest as a drug target.. Considering that the isatin scaffold is well-known for its versatile pharmacological properties, we synthesized and evaluated a series of compounds carrying an isatin core.

    Article Title: Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR
    Article Snippet: The dose-response curves were constructed by plotting the logarithmic scale of the concentrations and their corresponding %Inhibition values (GraphPad Prism 10; GraphPad Software).

    Article Title: Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
    Article Snippet: A one-way or two-way ANOVA, Tukey's multiple comparisons test (for multi-group comparisons), mixed-effects models, repeated measurements, dose-response curves, and Student's t-test were the bases for the statistical assessment, which was carried out using GraphPad 9.5.1.

    Article Title: Development and experimental validation of a machine learning model for the prediction of new antimalarials
    Article Snippet: The IC 50 of each compound was calculated by plotting sigmoidal dose-response curves in GraphPad Prism v 8.0.0. (GraphPad Software Inc., La Jolla, CA, USA).

    Concentration Assay:

    Article Title: An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.
    Article Snippet: Municipal wastewater treatment plants (WWTPs) release endocrine disrupting chemicals (EDCs) which can impact aquatic species’ reproduction (e.g., decrease fecundity).. As bioassays can quantify the cumulative effect of mixtures, such as effluents, this study proposes a two-Tier bioassay-based approach to assess EDCs in WWTP effluents.. The first Tier is composed of the human receptor transactivation assay for estrogen (hERα) and androgen (hAR), and the Tier 2 comprises an abbreviated 7-day fish short-term reproduction assay (FSTRA; OECD TG 229) in fathead minnow (Pimephales promelas).

    Article Title: Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models
    Article Snippet: The IC 50 values were calculated using dose–response curves and GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

    Article Title: Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice.
    Article Snippet: Mean temperature Δ across all timepoints post-injection was used to generate dose-response curves (GraphPad Prism 10: agonist vs. response, variable slope, Hill slope > − 5 or = − 5 (for etonitazene and (5)).

    Article Title: Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
    Article Snippet: Data points were then visualized using dose–response curves from PRISM v7.01 (GraphPad Software, La Jolla, CA, USA).

    Article Title: Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease.
    Article Snippet: The global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) urges the development of new antiviral agents with broad coronavirus coverage.. Due to its key role in viral evasion from the host innate immune response, the coronavirus Nsp15 uridine-specific endoribonuclease (EndoU) is of high interest as a drug target.. Considering that the isatin scaffold is well-known for its versatile pharmacological properties, we synthesized and evaluated a series of compounds carrying an isatin core.

    Article Title: Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR
    Article Snippet: The dose-response curves were constructed by plotting the logarithmic scale of the concentrations and their corresponding %Inhibition values (GraphPad Prism 10; GraphPad Software).

    Article Title: Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
    Article Snippet: A one-way or two-way ANOVA, Tukey's multiple comparisons test (for multi-group comparisons), mixed-effects models, repeated measurements, dose-response curves, and Student's t-test were the bases for the statistical assessment, which was carried out using GraphPad 9.5.1.

    Article Title: Development and experimental validation of a machine learning model for the prediction of new antimalarials
    Article Snippet: The IC 50 of each compound was calculated by plotting sigmoidal dose-response curves in GraphPad Prism v 8.0.0. (GraphPad Software Inc., La Jolla, CA, USA).

    Control:

    Article Title: An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.
    Article Snippet: Municipal wastewater treatment plants (WWTPs) release endocrine disrupting chemicals (EDCs) which can impact aquatic species’ reproduction (e.g., decrease fecundity).. As bioassays can quantify the cumulative effect of mixtures, such as effluents, this study proposes a two-Tier bioassay-based approach to assess EDCs in WWTP effluents.. The first Tier is composed of the human receptor transactivation assay for estrogen (hERα) and androgen (hAR), and the Tier 2 comprises an abbreviated 7-day fish short-term reproduction assay (FSTRA; OECD TG 229) in fathead minnow (Pimephales promelas).

    Article Title: Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models
    Article Snippet: The IC 50 values were calculated using dose–response curves and GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

    Article Title: Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice.
    Article Snippet: Mean temperature Δ across all timepoints post-injection was used to generate dose-response curves (GraphPad Prism 10: agonist vs. response, variable slope, Hill slope > − 5 or = − 5 (for etonitazene and (5)).

    Article Title: Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
    Article Snippet: Data points were then visualized using dose–response curves from PRISM v7.01 (GraphPad Software, La Jolla, CA, USA).

    Article Title: Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease.
    Article Snippet: The global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) urges the development of new antiviral agents with broad coronavirus coverage.. Due to its key role in viral evasion from the host innate immune response, the coronavirus Nsp15 uridine-specific endoribonuclease (EndoU) is of high interest as a drug target.. Considering that the isatin scaffold is well-known for its versatile pharmacological properties, we synthesized and evaluated a series of compounds carrying an isatin core.

    Article Title: Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR
    Article Snippet: The dose-response curves were constructed by plotting the logarithmic scale of the concentrations and their corresponding %Inhibition values (GraphPad Prism 10; GraphPad Software).

    Article Title: Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
    Article Snippet: A one-way or two-way ANOVA, Tukey's multiple comparisons test (for multi-group comparisons), mixed-effects models, repeated measurements, dose-response curves, and Student's t-test were the bases for the statistical assessment, which was carried out using GraphPad 9.5.1.

    Article Title: Development and experimental validation of a machine learning model for the prediction of new antimalarials
    Article Snippet: The IC 50 of each compound was calculated by plotting sigmoidal dose-response curves in GraphPad Prism v 8.0.0. (GraphPad Software Inc., La Jolla, CA, USA).

    Software:

    Article Title: An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.
    Article Snippet: Municipal wastewater treatment plants (WWTPs) release endocrine disrupting chemicals (EDCs) which can impact aquatic species’ reproduction (e.g., decrease fecundity).. As bioassays can quantify the cumulative effect of mixtures, such as effluents, this study proposes a two-Tier bioassay-based approach to assess EDCs in WWTP effluents.. The first Tier is composed of the human receptor transactivation assay for estrogen (hERα) and androgen (hAR), and the Tier 2 comprises an abbreviated 7-day fish short-term reproduction assay (FSTRA; OECD TG 229) in fathead minnow (Pimephales promelas).

    Article Title: Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models
    Article Snippet: The IC 50 values were calculated using dose–response curves and GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

    Article Title: Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice.
    Article Snippet: Mean temperature Δ across all timepoints post-injection was used to generate dose-response curves (GraphPad Prism 10: agonist vs. response, variable slope, Hill slope > − 5 or = − 5 (for etonitazene and (5)).

    Article Title: Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
    Article Snippet: Data points were then visualized using dose–response curves from PRISM v7.01 (GraphPad Software, La Jolla, CA, USA).

    Article Title: Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease.
    Article Snippet: The global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) urges the development of new antiviral agents with broad coronavirus coverage.. Due to its key role in viral evasion from the host innate immune response, the coronavirus Nsp15 uridine-specific endoribonuclease (EndoU) is of high interest as a drug target.. Considering that the isatin scaffold is well-known for its versatile pharmacological properties, we synthesized and evaluated a series of compounds carrying an isatin core.

    Article Title: Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR
    Article Snippet: The dose-response curves were constructed by plotting the logarithmic scale of the concentrations and their corresponding %Inhibition values (GraphPad Prism 10; GraphPad Software).

    Article Title: Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
    Article Snippet: A one-way or two-way ANOVA, Tukey's multiple comparisons test (for multi-group comparisons), mixed-effects models, repeated measurements, dose-response curves, and Student's t-test were the bases for the statistical assessment, which was carried out using GraphPad 9.5.1.

    Article Title: Development and experimental validation of a machine learning model for the prediction of new antimalarials
    Article Snippet: The IC 50 of each compound was calculated by plotting sigmoidal dose-response curves in GraphPad Prism v 8.0.0. (GraphPad Software Inc., La Jolla, CA, USA).

    Virus:

    Article Title: An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.
    Article Snippet: Municipal wastewater treatment plants (WWTPs) release endocrine disrupting chemicals (EDCs) which can impact aquatic species’ reproduction (e.g., decrease fecundity).. As bioassays can quantify the cumulative effect of mixtures, such as effluents, this study proposes a two-Tier bioassay-based approach to assess EDCs in WWTP effluents.. The first Tier is composed of the human receptor transactivation assay for estrogen (hERα) and androgen (hAR), and the Tier 2 comprises an abbreviated 7-day fish short-term reproduction assay (FSTRA; OECD TG 229) in fathead minnow (Pimephales promelas).

    Article Title: Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models
    Article Snippet: The IC 50 values were calculated using dose–response curves and GraphPad Prism 5 (GraphPad Software Inc., La Jolla, CA, USA).

    Article Title: Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice.
    Article Snippet: Mean temperature Δ across all timepoints post-injection was used to generate dose-response curves (GraphPad Prism 10: agonist vs. response, variable slope, Hill slope > − 5 or = − 5 (for etonitazene and (5)).

    Article Title: Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells.
    Article Snippet: Data points were then visualized using dose–response curves from PRISM v7.01 (GraphPad Software, La Jolla, CA, USA).

    Article Title: Exploration of isatin-based inhibitors of SARS-CoV-2 Nsp15 endoribonuclease.
    Article Snippet: The global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) urges the development of new antiviral agents with broad coronavirus coverage.. Due to its key role in viral evasion from the host innate immune response, the coronavirus Nsp15 uridine-specific endoribonuclease (EndoU) is of high interest as a drug target.. Considering that the isatin scaffold is well-known for its versatile pharmacological properties, we synthesized and evaluated a series of compounds carrying an isatin core.

    Article Title: Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR
    Article Snippet: The dose-response curves were constructed by plotting the logarithmic scale of the concentrations and their corresponding %Inhibition values (GraphPad Prism 10; GraphPad Software).

    Article Title: Ulinastatin modulates NLRP3 inflammasome pathway in PTZ-induced epileptic mice: A potential mechanistic insight
    Article Snippet: A one-way or two-way ANOVA, Tukey's multiple comparisons test (for multi-group comparisons), mixed-effects models, repeated measurements, dose-response curves, and Student's t-test were the bases for the statistical assessment, which was carried out using GraphPad 9.5.1.

    Article Title: Development and experimental validation of a machine learning model for the prediction of new antimalarials
    Article Snippet: The IC 50 of each compound was calculated by plotting sigmoidal dose-response curves in GraphPad Prism v 8.0.0. (GraphPad Software Inc., La Jolla, CA, USA).



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    Minitab Inc dose response curves
    The PDPK1/AKT/FLT DPI and tenovin-6 (T6) show high anti-cancer efficacy in murine tumoroids and human PCa cell lines <t>(A)</t> <t>Dose-response</t> curves for DPI (top) and T6 (bottom) for in vivo and in vitro Pten KO (left), Pten/Stat3 KO (middle), and Pten/Tp53 KO (right) tumoroids. Points represent means of technical duplicates per tumoroid line ( N = 3). Curve fitting was performed using GraphPad Prism 8.0.2. (B) Bar graphs showing means and ±SD of half-maximal inhibitory concentration (IC50) for DPI (top) and T6 (bottom) for in vivo and in vitro tumoroid lines of all genotypes ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA, Tukey’s test). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05. (C) Bar graphs depicting means and ±SD of IC50 values of DPI (left) and T6 (right) on human PCa cell lines. 22RV1: primary PCa; LNCaP: metastatic PCa; DU145, PC3: metastatic castration-resistant PCa ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05; ∗∗ p ≤ 0.01. (D) Heatmaps of synergy scores calculated with the highest single agent (HSA) model for DPI and enzalutamide (left), and T6 and enzalutamide (right) on the human LNCaP cell line. Values > 0 represent synergistic effects, and values < 0 represent antagonistic effects. IC50 concentrations of respective compounds are underlined ( N = 3). See also .
    Dose Response Curves, supplied by Minitab Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    The PDPK1/AKT/FLT DPI and tenovin-6 (T6) show high anti-cancer efficacy in murine tumoroids and human PCa cell lines <t>(A)</t> <t>Dose-response</t> curves for DPI (top) and T6 (bottom) for in vivo and in vitro Pten KO (left), Pten/Stat3 KO (middle), and Pten/Tp53 KO (right) tumoroids. Points represent means of technical duplicates per tumoroid line ( N = 3). Curve fitting was performed using GraphPad Prism 8.0.2. (B) Bar graphs showing means and ±SD of half-maximal inhibitory concentration (IC50) for DPI (top) and T6 (bottom) for in vivo and in vitro tumoroid lines of all genotypes ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA, Tukey’s test). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05. (C) Bar graphs depicting means and ±SD of IC50 values of DPI (left) and T6 (right) on human PCa cell lines. 22RV1: primary PCa; LNCaP: metastatic PCa; DU145, PC3: metastatic castration-resistant PCa ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05; ∗∗ p ≤ 0.01. (D) Heatmaps of synergy scores calculated with the highest single agent (HSA) model for DPI and enzalutamide (left), and T6 and enzalutamide (right) on the human LNCaP cell line. Values > 0 represent synergistic effects, and values < 0 represent antagonistic effects. IC50 concentrations of respective compounds are underlined ( N = 3). See also .
    Multipoint Dose Response Curve, supplied by Tecan Systems, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    The PDPK1/AKT/FLT DPI and tenovin-6 (T6) show high anti-cancer efficacy in murine tumoroids and human PCa cell lines <t>(A)</t> <t>Dose-response</t> curves for DPI (top) and T6 (bottom) for in vivo and in vitro Pten KO (left), Pten/Stat3 KO (middle), and Pten/Tp53 KO (right) tumoroids. Points represent means of technical duplicates per tumoroid line ( N = 3). Curve fitting was performed using GraphPad Prism 8.0.2. (B) Bar graphs showing means and ±SD of half-maximal inhibitory concentration (IC50) for DPI (top) and T6 (bottom) for in vivo and in vitro tumoroid lines of all genotypes ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA, Tukey’s test). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05. (C) Bar graphs depicting means and ±SD of IC50 values of DPI (left) and T6 (right) on human PCa cell lines. 22RV1: primary PCa; LNCaP: metastatic PCa; DU145, PC3: metastatic castration-resistant PCa ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05; ∗∗ p ≤ 0.01. (D) Heatmaps of synergy scores calculated with the highest single agent (HSA) model for DPI and enzalutamide (left), and T6 and enzalutamide (right) on the human LNCaP cell line. Values > 0 represent synergistic effects, and values < 0 represent antagonistic effects. IC50 concentrations of respective compounds are underlined ( N = 3). See also .
    Dose Response Curves, supplied by Eurofins, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    The PDPK1/AKT/FLT DPI and tenovin-6 (T6) show high anti-cancer efficacy in murine tumoroids and human PCa cell lines (A) Dose-response curves for DPI (top) and T6 (bottom) for in vivo and in vitro Pten KO (left), Pten/Stat3 KO (middle), and Pten/Tp53 KO (right) tumoroids. Points represent means of technical duplicates per tumoroid line ( N = 3). Curve fitting was performed using GraphPad Prism 8.0.2. (B) Bar graphs showing means and ±SD of half-maximal inhibitory concentration (IC50) for DPI (top) and T6 (bottom) for in vivo and in vitro tumoroid lines of all genotypes ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA, Tukey’s test). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05. (C) Bar graphs depicting means and ±SD of IC50 values of DPI (left) and T6 (right) on human PCa cell lines. 22RV1: primary PCa; LNCaP: metastatic PCa; DU145, PC3: metastatic castration-resistant PCa ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05; ∗∗ p ≤ 0.01. (D) Heatmaps of synergy scores calculated with the highest single agent (HSA) model for DPI and enzalutamide (left), and T6 and enzalutamide (right) on the human LNCaP cell line. Values > 0 represent synergistic effects, and values < 0 represent antagonistic effects. IC50 concentrations of respective compounds are underlined ( N = 3). See also .

    Journal: Cell Reports Methods

    Article Title: Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss

    doi: 10.1016/j.crmeth.2026.101370

    Figure Lengend Snippet: The PDPK1/AKT/FLT DPI and tenovin-6 (T6) show high anti-cancer efficacy in murine tumoroids and human PCa cell lines (A) Dose-response curves for DPI (top) and T6 (bottom) for in vivo and in vitro Pten KO (left), Pten/Stat3 KO (middle), and Pten/Tp53 KO (right) tumoroids. Points represent means of technical duplicates per tumoroid line ( N = 3). Curve fitting was performed using GraphPad Prism 8.0.2. (B) Bar graphs showing means and ±SD of half-maximal inhibitory concentration (IC50) for DPI (top) and T6 (bottom) for in vivo and in vitro tumoroid lines of all genotypes ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA, Tukey’s test). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05. (C) Bar graphs depicting means and ±SD of IC50 values of DPI (left) and T6 (right) on human PCa cell lines. 22RV1: primary PCa; LNCaP: metastatic PCa; DU145, PC3: metastatic castration-resistant PCa ( N = 3). Statistical analysis was performed using GraphPad Prism 8.0.2 (one-way ANOVA). p > 0.05 if not specified otherwise, ∗ p ≤ 0.05; ∗∗ p ≤ 0.01. (D) Heatmaps of synergy scores calculated with the highest single agent (HSA) model for DPI and enzalutamide (left), and T6 and enzalutamide (right) on the human LNCaP cell line. Values > 0 represent synergistic effects, and values < 0 represent antagonistic effects. IC50 concentrations of respective compounds are underlined ( N = 3). See also .

    Article Snippet: Dose-response curves for capivasertib (MedChemExpress # HY-15431), the PDPK1/AKT/FLT dual pathway inhibitor (DPI) (SantaCruz Biotechnology #CAS 331253-86-2) and tenovin-6 (T6) (MedChemExpress #1011301-29-3) were performed on in vivo and in vitro organoids and tumoroids.

    Techniques: In Vivo, In Vitro, Concentration Assay