Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: Formulation Compositions for the Preparation of NM, NM-HA, and NM-HON by ABN

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques: Formulation

Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: Comparative stability of MEL, neutralized MEL (NM) and NM-loaded formulations (NM-HA, and NM-HON) in pH 7.4 PBS (n = 3). **p < 0.01, ***p < 0.001. ****p<0.0001 One-way ANOVA compared with MEL.

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques: Stability

Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: Solid-state stability of freeze-dried NM, NM-HA, and NM-HON at 25 °C and 70 % RH (n = 3). *p<0.05, **p < 0.01, ****p<0.0001 One-way ANOVA compared with MEL.

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques: Stability

Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: FE-SEM images of MEL ( a ), HA ( b ), HOC ( c ), NM ( d ), NM-HA ( e ), and NM-HON ( f ).

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques:

Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: Fourier transform-infrared (FT-IR) spectra ( a ), differential scanning calorimetry (DSC) thermograms ( b ), and high power X- ray diffraction (HP-XRD) patterns ( c) of MEL, NM, NM-HA, NM-HON, and raw materials.

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques: Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry

Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: In vitro permeability profiles of MEL, NM, NM-HA, and NM-HON using permeation barrier membrane (PB-M) in pH 7.4 PBS (n = 3). **p < 0.01, ***p < 0.001. ****p<0.0001 One-Way ANOVA compared with MEL.

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques: In Vitro, Permeability, Membrane

Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: In vitro release profiles of MEL, NM, NM-HA, and NM-HON in pH 7.4 PBS ( a ), pH 5.2 ABS ( b ), and pH 7.4 PBS with 10 mM GSH ( c ) (n = 3). *p < 0.05, **p<0.01, ***p < 0.001. ****p<0.0001 One-way ANOVA compared with MEL.

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques: In Vitro

Journal: International Journal of Nanomedicine

Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles

doi: 10.2147/IJN.S618075

Figure Lengend Snippet: In vitro cytotoxicity of MEL, NM, NM-HA, and NM-HON in ARPE-19 normal cells ( a ) and WERI-Rb-1 cancer cells ( b ) after incubation for 24 h (n = 3). *p < 0.05, **p<0.01, ***p < 0.001. ****p<0.0001 One-way ANOVA compared with MEL.

Article Snippet: Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA).

Techniques: In Vitro, Incubation