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two compartment pk model  (MathWorks Inc)


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    MathWorks Inc two compartment pk model
    Two Compartment Pk Model, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 97/100, based on 595 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compartment+pk+model/SimBiology/bio_rxiv__2025__09__10__675318-90-26-30
    Average 97 stars, based on 595 article reviews
    two compartment pk model - by Bioz Stars, 2026-09
    97/100 stars

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    other:

    Article Title: Method of protecting tissue from damage by administering a bi-specific therapeutic protein comprising insulin-like growth factor 1 (IGF-1) and Annexin A5
    Article Snippet: A standard one- or two-compartment PK model was calibrated to experimental drug-serum decay data in mice using custom scripts written for the Simbiology MATLAB®software platform (Mathworks, Inc., Natick, MA).

    Article Title: Bi-specific therapeutic proteins, in vivo methods of use thereof and encoding nucleic acids thereof
    Article Snippet: A standard one- or two-compartment PK model was calibrated to experimental drug-serum decay data in mice using custom scripts written for the Simbiology MATLAB software platform (Mathworks, Inc., Natick, MA).

    Article Title: Method of inhibiting apoptosis or promoting cell survival by providing a bi-specific protein comprising insulin-like growth factor IGF-1 and Annexin A5
    Article Snippet: A standard one- or two-compartment PK model was calibrated to experimental drug-serum decay data in mice using custom scripts written for the Simbiology MATLAB software platform (Mathworks, Inc., Natick, Mass.).

    Article Title: Bi-specific annexin A5/IGF-1 proteins and methods of use thereof to promote regeneration and survival of tissue
    Article Snippet: A standard one- or two-compartment PK model was calibrated to experimental drug-serum decay data in mice using custom scripts written for the Simbiology MATLAB® software platform (Mathworks, Inc., Natick, Mass.).



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    Schematic diagram of the mechanistic in silico COVID‐19 model. The in silico model includes two main submodels: ( a ) COVID‐19 disease model and ( b ) pharmacological model. The disease model consists of three submodules: virus life cycle, immune response module in lung, and immune response module in the lymphatic compartment. The pharmacological model describes the pharmacokinetics processes that translate drug dose to clinical exposure and then links it to the disease model. In this figure, remdesivir is shown as an example, whose pharmacological model is linked to the disease model at the point of virus replication due to remdesivir's known effect of suppressing SARS‐CoV‐2 replication. <xref ref-type= 38 Drugs with other mechanisms of action may have other connection points. For example, pharmacological models of inflammation suppressors (e.g., IL‐6 antibody) can be linked to the disease model at the point of IL‐6 production. Multiple pharmacological modules (submodels) could be added to simulate drug combinations. COVID‐19, coronavirus disease 2019; EC 50 , half‐maximal effective concentration; Epi, epithelial cell; IFNα, interferon alpha; IL‐6, interleukin 6; IgG, immunoglobulin G; IgM, immunoglobulin M; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2. This figure is a high‐level summary of essential processes connected by sequential arrows, with solid lines ending in filled circles representing cell death induced by immune responses (for example cytotoxic T cells killing infected epithelial cells). More details about reaction interconnections, rates, parameters, and equations are provided in the Supplementary Document. " width="100%" height="100%">

    Journal: Clinical Pharmacology and Therapeutics

    Article Title: Calibration and Validation of a Mechanistic COVID‐19 Model for Translational Quantitative Systems Pharmacology – A Proof‐of‐Concept Model Development for Remdesivir

    doi: 10.1002/cpt.2686

    Figure Lengend Snippet: Schematic diagram of the mechanistic in silico COVID‐19 model. The in silico model includes two main submodels: ( a ) COVID‐19 disease model and ( b ) pharmacological model. The disease model consists of three submodules: virus life cycle, immune response module in lung, and immune response module in the lymphatic compartment. The pharmacological model describes the pharmacokinetics processes that translate drug dose to clinical exposure and then links it to the disease model. In this figure, remdesivir is shown as an example, whose pharmacological model is linked to the disease model at the point of virus replication due to remdesivir's known effect of suppressing SARS‐CoV‐2 replication. 38 Drugs with other mechanisms of action may have other connection points. For example, pharmacological models of inflammation suppressors (e.g., IL‐6 antibody) can be linked to the disease model at the point of IL‐6 production. Multiple pharmacological modules (submodels) could be added to simulate drug combinations. COVID‐19, coronavirus disease 2019; EC 50 , half‐maximal effective concentration; Epi, epithelial cell; IFNα, interferon alpha; IL‐6, interleukin 6; IgG, immunoglobulin G; IgM, immunoglobulin M; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2. This figure is a high‐level summary of essential processes connected by sequential arrows, with solid lines ending in filled circles representing cell death induced by immune responses (for example cytotoxic T cells killing infected epithelial cells). More details about reaction interconnections, rates, parameters, and equations are provided in the Supplementary Document.

    Article Snippet: Due to the complex PKs of remdesivir, the pharmacological model includes two sequential components ( Figure ): remdesivir compartmental PK model and remdesivir intracellular metabolism model. A two‐compartment PK model was used to convert remdesivir intravenous (i.v.) dose to plasma concentration.

    Techniques: In Silico, Concentration Assay, Infection