kinase 2 cdk2 assay kit (BPS Bioscience)
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BPS Bioscience
kinase 2 cdk2 assay kit
Kinase 2 Cdk2 Assay Kit, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 31 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cdk2+assay+kit/CDK2+Assay+Kit/pmc12932164-239-9-16
Average 94 stars, based on 31 article reviews
Kinase 2 Cdk2 Assay Kit, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 31 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cdk2+assay+kit/CDK2+Assay+Kit/pmc12932164-239-9-16
Average 94 stars, based on 31 article reviews
kinase 2 cdk2 assay kit - by Bioz Stars,
2026-09
94/100 stars
Images
1) Product Images from "Antimicrobial, anticancer activities and molecular docking of eco-friendly chitosan nanocapsule loaded with biosynthesized titanium nanoparticles by Aspergillus flavus"
Article Title: Antimicrobial, anticancer activities and molecular docking of eco-friendly chitosan nanocapsule loaded with biosynthesized titanium nanoparticles by Aspergillus flavus
Journal: Frontiers in Microbiology
doi: 10.3389/fmicb.2026.1741753
Figure Legend Snippet: CDK2-CNCs complex showing the ligand positioned within the ATP-binding site. (A,B) The figure demonstrates the steric hindrance created by the titanium-chitosan complex that prevents ATP binding , (C) key residues involved in catalytic activity clearly labeled.
Techniques Used: Binding Assay, Activity Assay, Labeling
Related Articles
In Vitro:Article Title: Integrated structure- and ligand-based design, synthesis, and biological evaluation of potent thiazole-based multi-kinase PI3Kα and CDK2/8 inhibitors as anticancer agents. Article Snippet: A small library of novel potential multi-kinase inhibitors was designed by integrating structureand ligand-based design approaches through terms of hybridization and fragment-based design tools.. The required key pharmacophoric features for the individual kinases’ inhibition were fused to achieve the desired inhibitory activity against PI3Kα and CDK2, relying on our previously studied strategy of the structureand ligand-based design approaches’ expansion.. Thus, all the synthesized compounds were evaluated for their inhibitory activity against PI3Kα and CDK2/cyclin A2, in addition to CDK8/cyclin C. The newly synthesized compounds exhibited a promising activity at sub-micromolar concentrations toward the three enzymes, indicating the efficacy of the adopted strategies utilized in the current design. Activity Assay:Article Title: Integrated structure- and ligand-based design, synthesis, and biological evaluation of potent thiazole-based multi-kinase PI3Kα and CDK2/8 inhibitors as anticancer agents. Article Snippet: A small library of novel potential multi-kinase inhibitors was designed by integrating structureand ligand-based design approaches through terms of hybridization and fragment-based design tools.. The required key pharmacophoric features for the individual kinases’ inhibition were fused to achieve the desired inhibitory activity against PI3Kα and CDK2, relying on our previously studied strategy of the structureand ligand-based design approaches’ expansion.. Thus, all the synthesized compounds were evaluated for their inhibitory activity against PI3Kα and CDK2/cyclin A2, in addition to CDK8/cyclin C. The newly synthesized compounds exhibited a promising activity at sub-micromolar concentrations toward the three enzymes, indicating the efficacy of the adopted strategies utilized in the current design. Article Title: Discovery of pyrazolo[1,5-a]pyrimidines: Synthesis, in silico insights, and anticancer activity via novel CDK2/Tubulin dual inhibition approach. Article Snippet: A series of new pyrazolo[1,5-a]pyrimidine derivatives was designed and synthesized as dual CDK2/tubulin polymerization inhibitors.. MTT cytotoxicity assay was conducted against five cancer cell lines and one normal cell line.. Compounds 6h, and 6q displayed the highest antiproliferative activity, with average IC50 values of 7.01 and 17.37 μM, respectively, against the tested cancer cell lines. Article Title: Design, synthesis, molecular docking, and evaluation of sulfonyl quinazoline analogues as promising liver cancer drugs. Article Snippet: Inhibiting cyclin-dependent kinases (CDK) offers an important arsenal for cancer treatments by interfering with apoptotic proteins related to cancer.. Novel selective cyclin-dependent kinases inhibitors using the Quinazoline as the cap with multiple electronic donating (EDG) and/or electron withdrawing group (EWG) substituted Aniline chain at the C-2 position were designed, synthesized, and evaluated for activity against liver cancer.. Among the tested compounds, compounds B34 and B35 emerged as potent candidates in the series, with IC50 values of 0.102 ± 0.04 μM and 0.058 ± 0.003 μM, respectively. Article Title: Development of Benzothiazole-grafted Pyrazolo[1,5-a]pyrimidines as new CDK2 inhibitors and anti-prostate cancer agents. Article Snippet: In the current medical era, CDK2 kinase has emerged as a promising target in the global fight against cancer.. Recent research reported the overexpression of CDK2 in prostate cancer cells, which highlighted the potential of CDK2 inhibition as a practical therapeutic approach for this disease that stands out as a challenging global health issue.. On account of their interesting biological activities, especially anti-cancer properties, the two privileged scaffolds benzothiazole and pyrazolo[1,5-a]pyrimidine were utilized in this study to develop three series of 16 novel small molecules (8a-k, 12a-c, and 14a-b) as potential anti-prostate cancer agents targeting CDK2. In Silico:Article Title: Design, synthesis, molecular docking, and evaluation of sulfonyl quinazoline analogues as promising liver cancer drugs. Article Snippet: Inhibiting cyclin-dependent kinases (CDK) offers an important arsenal for cancer treatments by interfering with apoptotic proteins related to cancer.. Novel selective cyclin-dependent kinases inhibitors using the Quinazoline as the cap with multiple electronic donating (EDG) and/or electron withdrawing group (EWG) substituted Aniline chain at the C-2 position were designed, synthesized, and evaluated for activity against liver cancer.. Among the tested compounds, compounds B34 and B35 emerged as potent candidates in the series, with IC50 values of 0.102 ± 0.04 μM and 0.058 ± 0.003 μM, respectively. Concentration Assay:Article Title: Design, synthesis, molecular docking, and evaluation of sulfonyl quinazoline analogues as promising liver cancer drugs. Article Snippet: Inhibiting cyclin-dependent kinases (CDK) offers an important arsenal for cancer treatments by interfering with apoptotic proteins related to cancer.. Novel selective cyclin-dependent kinases inhibitors using the Quinazoline as the cap with multiple electronic donating (EDG) and/or electron withdrawing group (EWG) substituted Aniline chain at the C-2 position were designed, synthesized, and evaluated for activity against liver cancer.. Among the tested compounds, compounds B34 and B35 emerged as potent candidates in the series, with IC50 values of 0.102 ± 0.04 μM and 0.058 ± 0.003 μM, respectively. Article Title: The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation Article Snippet: .. Each portion was promptly mixed on ice with components from a Synthesized:Article Title: Development of Benzothiazole-grafted Pyrazolo[1,5-a]pyrimidines as new CDK2 inhibitors and anti-prostate cancer agents. Article Snippet: In the current medical era, CDK2 kinase has emerged as a promising target in the global fight against cancer.. Recent research reported the overexpression of CDK2 in prostate cancer cells, which highlighted the potential of CDK2 inhibition as a practical therapeutic approach for this disease that stands out as a challenging global health issue.. On account of their interesting biological activities, especially anti-cancer properties, the two privileged scaffolds benzothiazole and pyrazolo[1,5-a]pyrimidine were utilized in this study to develop three series of 16 novel small molecules (8a-k, 12a-c, and 14a-b) as potential anti-prostate cancer agents targeting CDK2. Kinase Assay:Article Title: The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation Article Snippet: .. Each portion was promptly mixed on ice with components from a Sterility:Article Title: The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation Article Snippet: .. Each portion was promptly mixed on ice with components from a |