Journal: Molecules

Article Title: Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability

doi: 10.3390/molecules30051184

Figure Lengend Snippet: Nano preparation for improving bioavailability of flavonoids.

Article Snippet: Nanogel , Breviscapine , BRE-NG , intranasal administration , 3, 10, 50, 100 mg/mL , Male Sprague-Dawley rats , Cerebral ischemia reperfusion injury , Absolute bioavailability increased by about 142.80 times , [ ] .

Techniques: Drug discovery, Injection, Liposomes, Activity Assay, Raw Material, Coagulation

Journal: Renal Failure

Article Title: Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention

doi: 10.1080/0886022X.2022.2146512

Figure Lengend Snippet: Clinical efficacy and mechanism of action of Chinese herbs and active ingredients for DKD treatment.

Article Snippet: It has been proven that Chinese herbal medicines and their bioactive ingredients, such as polyphenols (e.g., breviscapine, puerarin, resveratrol, safflower yellow, silymarin, curcumin, icariin, and tanshinone), polysaccharides (e.g., lycium barbarum polysaccharides, astragalus polysaccharides, ramulus mori polysaccharides, and Chinese Yam polysaccharides), alkaloids (e.g., berberine, tripterygium glycosides, ligustrazine, and emodin), and saponins (e.g., astragaloside and ginsenoside), can improve glucose metabolism and reduce renal pathological changes via multiple anti-inflammatory and anti-fibrotic pathways involved in oxidative stress, playing a nephroprotective role.

Techniques: Activity Assay, Activation Assay, Expressing, Protein-Protein interactions