Journal: Renal Failure

Article Title: Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention

doi: 10.1080/0886022X.2022.2146512

Figure Lengend Snippet: Clinical efficacy and mechanism of action of Chinese herbs and active ingredients for DKD treatment.

Article Snippet: It has been proven that Chinese herbal medicines and their bioactive ingredients, such as polyphenols (e.g., breviscapine, puerarin, resveratrol, safflower yellow, silymarin, curcumin, icariin, and tanshinone), polysaccharides (e.g., lycium barbarum polysaccharides, astragalus polysaccharides, ramulus mori polysaccharides, and Chinese Yam polysaccharides), alkaloids (e.g., berberine, tripterygium glycosides, ligustrazine, and emodin), and saponins (e.g., astragaloside and ginsenoside), can improve glucose metabolism and reduce renal pathological changes via multiple anti-inflammatory and anti-fibrotic pathways involved in oxidative stress, playing a nephroprotective role.

Techniques: Activity Assay, Activation Assay, Expressing, Protein-Protein interactions

Journal: Drug Design, Development and Therapy

Article Title: Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway

doi: 10.2147/DDDT.S293382

Figure Lengend Snippet: Breviscapine reduced the serum levels of markers of myocardial injury (n = 4 for each group). ( A ) The levels of cTnI in the four groups. ( B ) The levels of LDH in the four groups. ( C ) The levels of CK-MB in the four groups. Data are presented as the mean±standard deviation (SD). * P < 0.05 versus the sham group; # P < 0.05 versus the CME group; & P < 0.05 versus the CME + BE group.

Article Snippet: In particular, rats in the CME + BE and CME + BE + LY groups received breviscapine (Baishan Pharmaceutical Co., Ltd, Hebei, China) at a dose of 40 mg/kg daily by gavage, for 7 days before inducing CME.

Techniques: Standard Deviation

Journal: Drug Design, Development and Therapy

Article Title: Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway

doi: 10.2147/DDDT.S293382

Figure Lengend Snippet: Pretreatment with breviscapine attenuated CME-induced myocardial inflammation (n = 4 for each group). ( A ) The mRNA expression levels of TNF-α and IL-1β in cardiac tissues. ( B ) The protein expression levels of TNF-α and IL-1β in cardiac tissues. Data are presented as the mean±standard deviation (SD). * P < 0.05 versus the sham group; # P < 0.05 versus the CME group; & P < 0.05 versus the CME + BE group.

Article Snippet: In particular, rats in the CME + BE and CME + BE + LY groups received breviscapine (Baishan Pharmaceutical Co., Ltd, Hebei, China) at a dose of 40 mg/kg daily by gavage, for 7 days before inducing CME.

Techniques: Expressing, Standard Deviation

Journal: Drug Design, Development and Therapy

Article Title: Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway

doi: 10.2147/DDDT.S293382

Figure Lengend Snippet: Pretreatment with breviscapine attenuated CME-induced myocardial apoptosis (n = 4 for each group). ( A ) The mRNA expression levels of Bcl-2, Bax and cleaved caspase-3 in cardiac tissues. ( B ) The protein expression levels of Bcl-2, Bax and cleaved caspase-3 in cardiac tissues. ( C ) Representative immunohistochemical pictures of Bcl-2, Bax and cleaved caspase-3 in cardiac tissues (×200 magnification; bar = 100 μm). Data are presented as the mean±standard deviation (SD). * P < 0.05 versus the sham group; # P < 0.05 versus the CME group; & P < 0.05 versus the CME + BE group.

Article Snippet: In particular, rats in the CME + BE and CME + BE + LY groups received breviscapine (Baishan Pharmaceutical Co., Ltd, Hebei, China) at a dose of 40 mg/kg daily by gavage, for 7 days before inducing CME.

Techniques: Expressing, Immunohistochemical staining, Standard Deviation

Journal: Drug Design, Development and Therapy

Article Title: Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway

doi: 10.2147/DDDT.S293382

Figure Lengend Snippet: Effect of breviscapine on PI3K/Akt/GSK-3β-associated protein expression in cardiac tissues (n = 4 for each group). Data are presented as the mean±standard deviation (SD). * P < 0.05 versus the sham group; # P < 0.05 versus the CME group; & P < 0.05 versus the CME + BE group.

Article Snippet: In particular, rats in the CME + BE and CME + BE + LY groups received breviscapine (Baishan Pharmaceutical Co., Ltd, Hebei, China) at a dose of 40 mg/kg daily by gavage, for 7 days before inducing CME.

Techniques: Expressing, Standard Deviation

Journal: Molecules

Article Title: Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant

doi: 10.3390/molecules24122322

Figure Lengend Snippet: Anti-tyrosinase activity of arbutin and flavonoids.

Article Snippet: Quercetin, morin, festin, myricetin, rutin, and breviscapine were purchased from DATIAN Biology Co (Shanxi, China), β-arbutin from Beijing Brilliance Biochemical Co, Ltd (Beijing, China), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) from Guangzhou Qiyun Bio-technology Co (Guangzhou, China).

Techniques: Activity Assay

Journal: Molecules

Article Title: Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant

doi: 10.3390/molecules24122322

Figure Lengend Snippet: 1,1-diphenyl-2-picrylhydrazyl (PPH) radical scavenging activity of flavonoids.

Article Snippet: Quercetin, morin, festin, myricetin, rutin, and breviscapine were purchased from DATIAN Biology Co (Shanxi, China), β-arbutin from Beijing Brilliance Biochemical Co, Ltd (Beijing, China), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) from Guangzhou Qiyun Bio-technology Co (Guangzhou, China).

Techniques: Activity Assay

Journal: Molecules

Article Title: Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability

doi: 10.3390/molecules30051184

Figure Lengend Snippet: Nano preparation for improving bioavailability of flavonoids.

Article Snippet: Nanogel , Breviscapine , BRE-NG , intranasal administration , 3, 10, 50, 100 mg/mL , Male Sprague-Dawley rats , Cerebral ischemia reperfusion injury , Absolute bioavailability increased by about 142.80 times , [ ] .

Techniques: Drug discovery, Injection, Liposomes, Activity Assay, Raw Material, Coagulation