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Pfizer Inc bivalent bnt162b2
Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; <t>BNT162b2),</t> first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.
Bivalent Bnt162b2, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bivalent+bnt162b2/bnt162b2+%EA%B2%B0%EA%B3%BC%EB%A5%BC+%EB%95%8C+%EB%B3%BC+%EC%A2%85+%ED%95%A9%ED%95%B4+%ED%98%88%EC%95%A1%EA%B2%80%EC%82%AC/pmc13154980-26-8-11
Average 86 stars, based on 1 article reviews
bivalent bnt162b2 - by Bioz Stars, 2026-11
86/100 stars

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1) Product Images from "NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants"

Article Title: NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants

Journal: Human Vaccines & Immunotherapeutics

doi: 10.1080/21645515.2026.2638022

Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; BNT162b2), first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.
Figure Legend Snippet: Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; BNT162b2), first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.

Techniques Used: Comparison, Infection

Related Articles

Vaccines:

Article Title: NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants
Article Snippet: Reflecting the changing variant landscape, in August 2022 the US Food and Drug Administration (FDA) granted emergency use authorizations to bivalent formulations of the Moderna and Pfizer-BioNtech mRNA vaccines that target both the ancestral SARS-CoV-2 strain and the Omicron BA.4/5 lineages. .. In Singapore, the bivalent mRNA-1273 (ancestral/BA.1, Moderna) and bivalent BNT162b2 (ancestral/BA.4/5, Pfizer) vaccines were added to the National Vaccination Programme from October 2022 and were recommended in place of the original monovalent vaccines. ..



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Pfizer Inc bivalent bnt162b2
Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; <t>BNT162b2),</t> first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.
Bivalent Bnt162b2, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; <t>BNT162b2),</t> first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.
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Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; <t>BNT162b2),</t> first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.
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Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; <t>BNT162b2),</t> first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.
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Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; <t>BNT162b2),</t> first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.
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Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; BNT162b2), first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.

Journal: Human Vaccines & Immunotherapeutics

Article Title: NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants

doi: 10.1080/21645515.2026.2638022

Figure Lengend Snippet: Longitudinal measurements and kinetics of SARS-CoV-2 anti-spike (S) antibody over a 1-y study period. (a) Level of anti-S antibody between different vaccine groups. Data was analysed using one-way ANOVA with Holm-Sidak’s multiple comparisons test. Bars depict mean and 95% CI. (b) Kinetics of anti-S antibody from D28 post-booster. Data presented are geometric mean concentrations and 95% CI. (c) Summary data. (d) Comparison of anti-S titres at D28, D180 and D360, and D360-to-D28 ratio. One multiple linear regression model was fitted for each time point, adjusting for baseline anti-S titres, age group (<60 y; ≥60 y), the interval between first and second boosters (≤1 y; >1 y), primary vaccination series (mRNA-1273; BNT162b2), first booster (mRNA-1273; BNT162b2), sex and prior SARS-CoV-2 infection. GM: geometric mean; GMR: geometric mean ratio. *** p < .001; **** p < .0001.

Article Snippet: In Singapore, the bivalent mRNA-1273 (ancestral/BA.1, Moderna) and bivalent BNT162b2 (ancestral/BA.4/5, Pfizer) vaccines were added to the National Vaccination Programme from October 2022 and were recommended in place of the original monovalent vaccines.

Techniques: Comparison, Infection

<xref ref-type= Thomas 2022 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Thomas 2022

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Biomarker Discovery, Vaccines, Comparison, Saline, Injection

<xref ref-type= Zhao 2024 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Zhao 2024

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection

<xref ref-type= Hayashi 2023 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Hayashi 2023

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection

<xref ref-type= Lau 2022 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Lau 2022

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection

<xref ref-type= Leuva 2022 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Leuva 2022

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection

<xref ref-type= Thomas 2022 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Thomas 2022

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Biomarker Discovery, Vaccines, Comparison, Saline, Injection

<xref ref-type= Zhao 2024 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Zhao 2024

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection

<xref ref-type= Hayashi 2023 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Hayashi 2023

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection

<xref ref-type= Lau 2022 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Lau 2022

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection

<xref ref-type= Leuva 2022 " width="100%" height="100%">

Journal: The Cochrane Database of Systematic Reviews

Article Title: Vaccines for preventing infections in adults with solid tumours

doi: 10.1002/14651858.CD015551.pub2

Figure Lengend Snippet: Leuva 2022

Article Snippet: As of 30 August 2023, those were: BNT162b2; BNT162b2 Bivalent WT/OMI BA.1; BNT162b2 Bivalent WT/OMI BA.4/BA.5 (Comirnaty; Biontech Pfizer); mRNA1273; mRNA‐1273.214 Original/Omicron BA.1; mRNA‐1273.222 Original/Omicron BA.4/BA.5 (Spikevax; Moderna); AZD12222 (Vaxzevria; AstraZeneca); Ad26.COV2.S (COVID‐19 Vaccine Janssen); Sputnik V (Gamaleya); Sputnik Light (Gamaleya); BBIBP‐CorV* (Sinopharm; Beijing CNBG); CoronaVac* (Sinovac); BBV152* (Covaxin); Ad5‐nCoV (Convidecia); NVX‐CoV2373 (Nuvaxovid; Novavax); VidPrevtyn Beta (Sanofi/GSK); VLA2001* (Valneva).

Techniques: Control, Infection, Vaccines, Comparison, Injection