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azd1152  (MedChemExpress)
94
MedChemExpress azd1152
Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, <t>AZD1152</t> (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
Azd1152, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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azd1152-hqpa/azd2811 (barasertib)  (Selleck Chemicals)
90
Selleck Chemicals azd1152-hqpa/azd2811 (barasertib)
Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, <t>AZD1152</t> (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
Azd1152 Hqpa/Azd2811 (Barasertib), supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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azd1152 aurkb c  (Selleck Chemicals)
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Selleck Chemicals azd1152 aurkb c
Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, <t>AZD1152</t> (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
Azd1152 Aurkb C, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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azd1152-hqpa  (Cayman Chemical)
90
Cayman Chemical azd1152-hqpa
Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, <t>AZD1152</t> (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
Azd1152 Hqpa, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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azd2811 azd1152-hqpa  (Millipore)
90
Millipore azd2811 azd1152-hqpa
Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, <t>AZD1152</t> (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
Azd2811 Azd1152 Hqpa, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/azd2811 azd1152-hqpa/product/Millipore
Average 90 stars, based on 1 article reviews
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barasertib azd1152 hqpa  (Selleck Chemicals)
94
Selleck Chemicals barasertib azd1152 hqpa
Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, <t>AZD1152</t> (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.
Barasertib Azd1152 Hqpa, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.

Journal: Nucleic Acids Research

Article Title: Chromatin-associated α-satellite RNA maintains chromosome stability by reestablishing SAF-A in the mitotic cell cycle

doi: 10.1093/nar/gkaf294

Figure Lengend Snippet: Aurora kinases regulate the expression of α-satellite RNA. ( A ) Representative western blotting demonstrates the inhibition of Aurora kinases in synchronized cells. AURKA inhibitor, TC-S7010 (2.5 μM); AURKB inhibitor, AZD1152 (0.25 μM). H3S10P serves as positive control; ACTB, β-actin, serves as the internal loading control. ( B ) Quantification of H3S10P western blot in (A). ( C ) RT-qPCR analysis showing relative α-satellite RNA levels upon Aurora kinase inhibition. DMSO, no drug control. Results are normalized to Async no drug control. The error bars represent SD, n = 6. Statistical significance is calculated using unpaired t-tests and is reported as P < 0.05 *, P < 0.01 **, P < 0.001 ***, P < 0.0001 ****. ( D ) Representative images of α-satellite RNAs (αSAT) smFISH, CREST, and H3S10P IF in cells treated with Aurora kinase inhibitors. Scale bar, 10 μm.

Article Snippet: To inhibit Aurora kinases, 2.5 μM of TC-S7010 (MedChemExpress) and 0.25 μM of AZD1152 (MedChemExpress) were added to the culture medium 0.5 h before sample collection [ , ].

Techniques: Expressing, Western Blot, Inhibition, Positive Control, Control, Quantitative RT-PCR