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acinetobacter baumannii atcc 19003  (ATCC)


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    ATCC acinetobacter baumannii atcc 19003
    Acinetobacter Baumannii Atcc 19003, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 11 article reviews
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    MIC (μg/mL), in vitro cytotoxicity and kidney exposure of alpha substituted aminobutyrates and aminopropionates

    Journal: ACS infectious diseases

    Article Title: Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206

    doi: 10.1021/acsinfecdis.9b00217

    Figure Lengend Snippet: MIC (μg/mL), in vitro cytotoxicity and kidney exposure of alpha substituted aminobutyrates and aminopropionates

    Article Snippet: Open in a separate window R Diastereomer a E. coli IHMA558090 E. coli ATCC 25922 K. pneumoniae ATCC 13882 P. aeruginosa ATCC 27853 A. baumannii NCTC13424 A. baumannii ATCC 19003 Cytotoxicity HK-2 Rel to PMB 4h kidney level ( μ g/g) Kidney AUC 4-16 ( μ g.h/g) 40 n-pentyl D1 4 0.06 0.06 0.125 0.06 0.25 5.9 224 1435 41 n-pentyl D2 4 0.06 0.06 0.125 0.06 0.5 6.6 470 3058 42 cyclohexyl D1 4 0.06 0.125 0.06 0.25 ND 6.9 198 ND 43 cyclohexyl D2 8 0.25 0.25 0.125 0.25 0.25 7.9 ND ND 44 3-chlorophenyl D1 8 0.125 0.125 0.25 0.06 0.125 11.6 170 850 45 3-chlorophenyl D2 8 0.125 0.125 0.125 0.5 ND 7.8 381 ND 46 benzyl D1 8 0.25 0.25 0.125 0.125 2.0 12.0 159 847 47 benzyl D2 8 0.125 0.5 0.125 0.25 ND 8 346 ND Open in a separate window ND=not determined. a Compounds structures are denoted D1 or D2 on the basis of elution order and by comparison with the NMR of ( 44 ) and ( 45 ) of known absolute stereochemistry ( supplementary data ).

    Techniques: In Vitro

    MIC (μg/mL), in vitro cytotoxicity and kidney exposure of beta substituted aminobutyrates

    Journal: ACS infectious diseases

    Article Title: Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206

    doi: 10.1021/acsinfecdis.9b00217

    Figure Lengend Snippet: MIC (μg/mL), in vitro cytotoxicity and kidney exposure of beta substituted aminobutyrates

    Article Snippet: Open in a separate window R Diastereomer a E. coli IHMA558090 E. coli ATCC 25922 K. pneumoniae ATCC 13882 P. aeruginosa ATCC 27853 A. baumannii NCTC13424 A. baumannii ATCC 19003 Cytotoxicity HK-2 Rel to PMB 4h kidney level ( μ g/g) Kidney AUC 4-16 ( μ g.h/g) 40 n-pentyl D1 4 0.06 0.06 0.125 0.06 0.25 5.9 224 1435 41 n-pentyl D2 4 0.06 0.06 0.125 0.06 0.5 6.6 470 3058 42 cyclohexyl D1 4 0.06 0.125 0.06 0.25 ND 6.9 198 ND 43 cyclohexyl D2 8 0.25 0.25 0.125 0.25 0.25 7.9 ND ND 44 3-chlorophenyl D1 8 0.125 0.125 0.25 0.06 0.125 11.6 170 850 45 3-chlorophenyl D2 8 0.125 0.125 0.125 0.5 ND 7.8 381 ND 46 benzyl D1 8 0.25 0.25 0.125 0.125 2.0 12.0 159 847 47 benzyl D2 8 0.125 0.5 0.125 0.25 ND 8 346 ND Open in a separate window ND=not determined. a Compounds structures are denoted D1 or D2 on the basis of elution order and by comparison with the NMR of ( 44 ) and ( 45 ) of known absolute stereochemistry ( supplementary data ).

    Techniques: In Vitro