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app23 mice  (Novartis)

 
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    Novartis app23 mice
    App23 Mice, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/app23+mice/app23+mice/pm40394225-369-3-29
    Average 90 stars, based on 1 article reviews
    app23 mice - by Bioz Stars, 2026-10
    90/100 stars

    Images

    Related Articles

    Transgenic Assay:

    Article Title: Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice.
    Article Snippet: Individuals with type 2 diabetes mellitus have an increased risk of developing Alzheimer’s disease (AD).. GLP-1 receptor agonists (GLP-1RAs) are used for glycemic control in diabetes and show potential neuroprotective properties, but their effects on AD and the underlying mechanisms are not well understood.. Here we demonstrate that GLP-1RAs can alleviate AD-related phenotypes by activating 5′ AMP-activated protein kinase (AMPK) signaling.

    Mutagenesis:

    Article Title: Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice.
    Article Snippet: Individuals with type 2 diabetes mellitus have an increased risk of developing Alzheimer’s disease (AD).. GLP-1 receptor agonists (GLP-1RAs) are used for glycemic control in diabetes and show potential neuroprotective properties, but their effects on AD and the underlying mechanisms are not well understood.. Here we demonstrate that GLP-1RAs can alleviate AD-related phenotypes by activating 5′ AMP-activated protein kinase (AMPK) signaling.

    Article Title: Absence of tissue transglutaminase reduces amyloid‐beta pathology in APP23 mice
    Article Snippet: .. APP23 mice, overexpressing human APP751 carrying the Swedish double mutation (K670M/N671L) [ ], were obtained from Novartis (a generous gift from Dr Derya R. Shimshek, Novartis Institutes of BioMedical Research, Neuroscience, Basel, Switzerland). ..

    Article Title: GADD34 suppresses eIF2α phosphorylation and improves cognitive function in Alzheimer's disease-model mice.
    Article Snippet: Alzheimer's disease (AD) causes neurodegeneration, leading to cognitive impairment and memory loss.. Our previous studies have demonstrated that the induction of growth arrest and DNA damage-inducible gene 34 (GADD34) by quercetin can affect eukaryotic translation initiation factor 2a (eIF2a) phosphorylation-activated transcription factor 4 (ATF4) signaling.. However, the relationship between GADD34 expression and cognitive function has not been clarified.

    Article Title: The Transglutaminase-2 Interactome in the APP23 Mouse Model of Alzheimer's Disease.
    Article Snippet: .. APP23 mice, overexpressing human APP751 carrying the Swedish double mutation (K670M/N671L) [27], were obtained from Novartis (generous gift from Dr. Derya R. Shimshek, Novartis Institutes of BioMedical Research, Neuroscience, Basel, Switzerland). ..

    Control:

    Article Title: Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice.
    Article Snippet: Individuals with type 2 diabetes mellitus have an increased risk of developing Alzheimer’s disease (AD).. GLP-1 receptor agonists (GLP-1RAs) are used for glycemic control in diabetes and show potential neuroprotective properties, but their effects on AD and the underlying mechanisms are not well understood.. Here we demonstrate that GLP-1RAs can alleviate AD-related phenotypes by activating 5′ AMP-activated protein kinase (AMPK) signaling.

    Generated:

    Article Title: Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice
    Article Snippet: For spinosin, the extracts were separated by HPLC using a reverse-phase Unison UK-C18 column (Imtakt USA, Portland, OR, USA) with 0.1% formic acid and methanol mixture (65:35) as the mobile phase. .. APP23 mice were kindly provided by Novartis Pharma, Inc, Tau784 mice were generated in our laboratory, and Huα-Syn(A53T) mice were purchased from the Jackson Laboratory (Bar Harbor, ME, USA). ..

    Knock-Out:

    Article Title: Peripheral Aβ acts as a negative modulator of insulin secretion
    Article Snippet: .. C57BL/6 wild-type mice were purchased from Japan SLC, Inc. (Hamamatsu, Japan), APP23 mice were kindly provided by Novartis Pharma, Inc., and APP knockout mice were purchased from the Jackson Laboratory (Bar Harbor, ME). ..



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    ( A ) Representative T2*-weighted cerebral MRI sections of <t>APP23</t> mice chronically treated with saline or rhApoJ and WT mice treated with saline. CMB are indicated with red arrows. Graphical representation of the total number of hemorrhagic lesions. ( B ) Graphical representation of the number of hemorrhagic lesions, CMB (50–300 μm diameter) and large hemorrhagic lesions (> 300 μm) in the cortex, and ( C ) in deep brain regions (thalamus and basal ganglia). ( D ) Comparison of cerebral hemorrhagic lesions in T2*-MRI and Prussian blue staining showing iron hemosiderin deposits. The scale bar represents 20 μm. Data are presented as the mean + SD. #: count; *: p < 0.05; **: p < 0.01; ***: p < 0.001
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    ( A ) Representative T2*-weighted cerebral MRI sections of <t>APP23</t> mice chronically treated with saline or rhApoJ and WT mice treated with saline. CMB are indicated with red arrows. Graphical representation of the total number of hemorrhagic lesions. ( B ) Graphical representation of the number of hemorrhagic lesions, CMB (50–300 μm diameter) and large hemorrhagic lesions (> 300 μm) in the cortex, and ( C ) in deep brain regions (thalamus and basal ganglia). ( D ) Comparison of cerebral hemorrhagic lesions in T2*-MRI and Prussian blue staining showing iron hemosiderin deposits. The scale bar represents 20 μm. Data are presented as the mean + SD. #: count; *: p < 0.05; **: p < 0.01; ***: p < 0.001
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    Image Search Results


    ( A ) Representative T2*-weighted cerebral MRI sections of APP23 mice chronically treated with saline or rhApoJ and WT mice treated with saline. CMB are indicated with red arrows. Graphical representation of the total number of hemorrhagic lesions. ( B ) Graphical representation of the number of hemorrhagic lesions, CMB (50–300 μm diameter) and large hemorrhagic lesions (> 300 μm) in the cortex, and ( C ) in deep brain regions (thalamus and basal ganglia). ( D ) Comparison of cerebral hemorrhagic lesions in T2*-MRI and Prussian blue staining showing iron hemosiderin deposits. The scale bar represents 20 μm. Data are presented as the mean + SD. #: count; *: p < 0.05; **: p < 0.01; ***: p < 0.001

    Journal: Alzheimer's Research & Therapy

    Article Title: The presence of circulating human apolipoprotein J reduces the occurrence of cerebral microbleeds in a transgenic mouse model with cerebral amyloid angiopathy

    doi: 10.1186/s13195-024-01541-5

    Figure Lengend Snippet: ( A ) Representative T2*-weighted cerebral MRI sections of APP23 mice chronically treated with saline or rhApoJ and WT mice treated with saline. CMB are indicated with red arrows. Graphical representation of the total number of hemorrhagic lesions. ( B ) Graphical representation of the number of hemorrhagic lesions, CMB (50–300 μm diameter) and large hemorrhagic lesions (> 300 μm) in the cortex, and ( C ) in deep brain regions (thalamus and basal ganglia). ( D ) Comparison of cerebral hemorrhagic lesions in T2*-MRI and Prussian blue staining showing iron hemosiderin deposits. The scale bar represents 20 μm. Data are presented as the mean + SD. #: count; *: p < 0.05; **: p < 0.01; ***: p < 0.001

    Article Snippet: APP23 C57BL/6 mice (B6.Cg-Tg (Thy1-APP) 3Somm/J) mice were obtained from The Jackson Laboratory (Bar Harbor, ME, USA) and C57BL/6 WT mice were obtained from Janvier Labs (Le Genest-Saint-Isle, France).

    Techniques: Saline, Comparison, Staining

    ( A ) Representative images of immunofluorescence staining of fibrinogen in green from brain sections of APP23 mice chronically treated with saline or rhApoJ and WT mice. ( B ) Graphical quantification of fibrinogen-positive cerebral vessels. Correlation between the number of fibrinogen-positive vessels and the number of cerebral hemorrhagic lesions detected by T2*-MRI. ( C ) Representative images of immunohistochemical staining of sma in brown from brain sections of APP23 mice chronically treated with saline or rhApoJ and WT mice. ( D ) Graphical quantification of sma-positive cerebral vessels per mm 2 . Correlation between the number of sma-positive vessels and the number of hemorrhagic lesions. The scale bar represents 50 μm. Data are presented as boxplots. #: count; *: p < 0.05; **: p < 0.01; ***: p < 0.001

    Journal: Alzheimer's Research & Therapy

    Article Title: The presence of circulating human apolipoprotein J reduces the occurrence of cerebral microbleeds in a transgenic mouse model with cerebral amyloid angiopathy

    doi: 10.1186/s13195-024-01541-5

    Figure Lengend Snippet: ( A ) Representative images of immunofluorescence staining of fibrinogen in green from brain sections of APP23 mice chronically treated with saline or rhApoJ and WT mice. ( B ) Graphical quantification of fibrinogen-positive cerebral vessels. Correlation between the number of fibrinogen-positive vessels and the number of cerebral hemorrhagic lesions detected by T2*-MRI. ( C ) Representative images of immunohistochemical staining of sma in brown from brain sections of APP23 mice chronically treated with saline or rhApoJ and WT mice. ( D ) Graphical quantification of sma-positive cerebral vessels per mm 2 . Correlation between the number of sma-positive vessels and the number of hemorrhagic lesions. The scale bar represents 50 μm. Data are presented as boxplots. #: count; *: p < 0.05; **: p < 0.01; ***: p < 0.001

    Article Snippet: APP23 C57BL/6 mice (B6.Cg-Tg (Thy1-APP) 3Somm/J) mice were obtained from The Jackson Laboratory (Bar Harbor, ME, USA) and C57BL/6 WT mice were obtained from Janvier Labs (Le Genest-Saint-Isle, France).

    Techniques: Immunofluorescence, Staining, Saline, Immunohistochemical staining

    ( A ) Graphical quantification of plasma human ApoJ levels (hApoJ) (ng/mL) and representative image of human ApoJ immunodetection in a brain cortex section from a rhApoJ-treated APP23 mouse. A consecutive brain slice was stained with ThS to confirm the presence of CAA in the vessel. The scale bar represents 20 μm. ( B ) Graphical representation of plasma levels of Groα (pg/mL), MIP-1α (pg/mL), and MMP-12 (ng/mL) in mice from Group 2. Data are presented as boxplots. *: p < 0.05; ***: p < 0.001. ( C ) Correlation between plasma MMP-12 levels (ng/mL) and the number of large hemorrhagic lesions in the brain cortex (A) and the volume (mm 3 ) of cortical hemorrhagic lesions

    Journal: Alzheimer's Research & Therapy

    Article Title: The presence of circulating human apolipoprotein J reduces the occurrence of cerebral microbleeds in a transgenic mouse model with cerebral amyloid angiopathy

    doi: 10.1186/s13195-024-01541-5

    Figure Lengend Snippet: ( A ) Graphical quantification of plasma human ApoJ levels (hApoJ) (ng/mL) and representative image of human ApoJ immunodetection in a brain cortex section from a rhApoJ-treated APP23 mouse. A consecutive brain slice was stained with ThS to confirm the presence of CAA in the vessel. The scale bar represents 20 μm. ( B ) Graphical representation of plasma levels of Groα (pg/mL), MIP-1α (pg/mL), and MMP-12 (ng/mL) in mice from Group 2. Data are presented as boxplots. *: p < 0.05; ***: p < 0.001. ( C ) Correlation between plasma MMP-12 levels (ng/mL) and the number of large hemorrhagic lesions in the brain cortex (A) and the volume (mm 3 ) of cortical hemorrhagic lesions

    Article Snippet: APP23 C57BL/6 mice (B6.Cg-Tg (Thy1-APP) 3Somm/J) mice were obtained from The Jackson Laboratory (Bar Harbor, ME, USA) and C57BL/6 WT mice were obtained from Janvier Labs (Le Genest-Saint-Isle, France).

    Techniques: Clinical Proteomics, Immunodetection, Slice Preparation, Staining