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blm  (Bethyl)


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    Structured Review

    Bethyl blm
    Blm, supplied by Bethyl, used in various techniques. Bioz Stars score: 95/100, based on 117 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+blm/BLM+Antibody/10__3390_slash_ijms27062635-108-21-23
    Average 95 stars, based on 117 article reviews
    blm - by Bioz Stars, 2026-10
    95/100 stars

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    Related Articles

    Immunofluorescence:

    Article Title: The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges.
    Article Snippet: .. Primary antibodies used in this study were: mouse anti-FLAG M2 (Sigma-Aldrich #F3165, RRID: AB_259529, 1:1000-1:2500), mouse anti-α-tubulin (Cell Signaling Technologies #3873, RRID: AB_1904178, 1:5000), mouse anti-GAPDH (Cell Signaling Technologies #97166, RRID: AB_2756824, 1:5000), mouse anti-V5 (Cell Signaling Technologies #D3H8Q; 1:1000), anti-BLM (Cell Signaling Technologies #2742; Bethyl Laboratories #A300-120A; 1:1000 for immunofluorescence), anti-ABRAXAS2 (Abcam #ab68801; 1:1000), anti-RAD54L2 (ABclonal #A6144, 1:1000), anti-ZZZ3 (Bethyl Laboratories #A303-331A; 1:1000), anti-TOP3A (Proteintech # 14525-1-AP; 1:1000), anti-RMI1 (Raised in house #6534, 1:500), anti-RAD51 (Abcam #ab133534), anti-MRE11(Novus Biologicals #NB100-473, 1:1000), anti-PICH (Sigma-Aldrich #04- 1540). .. Secondary antibodies used for immunoblotting were: goat anti-mouse IgG HRP (Invitrogen # 31430, 1:5000) and goat antirabbit IgG HRP (Invitrogen # 31460, 1:5000).

    Article Title: The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
    Article Snippet: .. Primary antibodies used in this study were: mouse anti-FLAG M2 (Sigma-Aldrich #F3165, RRID: AB_259529, 1:1000-1:2500), mouse anti- α -tubulin (Cell Signaling Technologies #3873, RRID: AB_1904178, 1:5000), mouse anti-GAPDH (Cell Signaling Technologies #97166, RRID: AB_2756824, 1:5000), mouse anti-V5 (Cell Signaling Technologies #D3H8Q; 1:1000), anti-BLM (Cell Signaling Technologies #2742; Bethyl Laboratories #A300-120A; 1:1000 for immunofluorescence), anti-ABRAXAS2 (Abcam #ab68801; 1:1000), anti-RAD54L2 (ABclonal #A6144, 1:1000), anti-ZZZ3 (Bethyl Laboratories #A303-331A; 1:1000), anti-TOP3A (Proteintech # 14525-1-AP; 1:1000), anti-RMI1 (Raised in house #6534, 1:500), anti-RAD51 (Abcam #ab133534), anti-MRE11(Novus Biologicals #NB100-473, 1:1000), anti-PICH (Sigma-Aldrich #04-1540). .. U2OS cells carrying the DR-GFP reporter (Pierce et al, ) were transfected with siRNAs as indicated above.

    Western Blot:

    Article Title: Arginine methylation-dependent METTL14-SMN interaction regulates RNA m 6 A homeostasis
    Article Snippet: The site-directed mutagenesis kit (Cat# 200523) was purchased from Agilent Technologies. .. The following antibodies were used for either IP or western blot analysis: anti-METTL14 (HPA038002, Sigma), anti-METTL3 (A301-567A, Bethyl Laboratories), anti-YTHDF1 (A13260, ABclonal), anti-YTHDF2 (A15616, ABclonal), anti-YTHDF3 (A8395, ABclonal), anti-YTHDC1 (A7318, ABclonal), anti-YTHDC2 (A15004, ABclonal), anti-FTO (A1438, ABclonal), anti-ALKBH5 (A11684, ABclonal), anti-m 6 A (ABE572-I-100UG, Sigma), anti-PRMT1 (A300-722A, Bethyl Laboratories), anti-BLM (A300-110A, Bethyl Laboratories), anti-FANCD2 (NB100-182SS, Novus Biologicals), anti-BRCA1 (A11549, ABclonal), anti-SMN (12976S, Cell Signaling Technology), anti-ATRIP (A7139, ABclonal), anti-FANCM (12954-1-AP, Proteintech), anti-PALB2 (14340-1-AP, Proteintech), anti-Flag (F3165, Sigma), anti-β-ACTIN (A5441, Sigma), anti-Tubulin (2144, Cell Signaling Technology), anti-RNAPII (39097, Active motif), rabbit anti-HA (3724S, Cell Signaling Technology), anti-SDMA (13222S, Cell Signaling Technology), and anti-ADMA (13522S, Cell Signaling Technology). ..

    Article Title: Arginine methylation-dependent METTL14-SMN interaction regulates RNA m 6 A homeostasis.
    Article Snippet: The site-directed mutagenesis kit (Cat# 200523) was purchased from Agilent Technologies. .. The following antibodies were used for either IP or western blot analysis: anti-METTL14 (HPA038002, Sigma), anti-METTL3 (A301567A, Bethyl Laboratories), anti-YTHDF1 (A13260, ABclonal), antiYTHDF2 (A15616, ABclonal), anti-YTHDF3 (A8395, ABclonal), anti-YTHDC1 (A7318, ABclonal), anti-YTHDC2 (A15004, ABclonal), anti-FTO (A1438, ABclonal), anti-ALKBH5 (A11684, ABclonal), anti-m6A (ABE572-I-100UG, Sigma), anti-PRMT1 (A300-722A, Bethyl Laboratories), anti-BLM (A300-110A, Bethyl Laboratories), anti-FANCD2 (NB100-182SS, Novus Biologicals), anti-BRCA1 (A11549, ABclonal), anti-SMN (12976S, Cell Signaling Technology), anti-ATRIP (A7139, ABclonal), anti-FANCM (12954-1-AP, Proteintech), anti-PALB2 (14340-1-AP, Proteintech), anti-Flag (F3165, Sigma), anti-β-ACTIN (A5441, Sigma), anti-Tubulin (2144, Cell Signaling Technology), anti-RNAPII (39097, Active motif), rabbit anti-HA (3724S, Cell Signaling Technology), anti-SDMA (13222S, Cell Signaling Technology), and anti-ADMA (13522S, Cell Signaling Technology). ..

    other:

    Article Title: Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers
    Article Snippet: After additional washes with TBS-T, membranes were treated with ECL reagent, and protein signals were detected using the Odyssey Imaging System (LI-COR 2800).

    Article Title: Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
    Article Snippet: Anti-BLM, rabbit polyclonal , Bethyl , Cat# #A300-110A RRID: AB_2064794.



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    <t>ESCO2</t> deficiency results in telomere abnormalities. ( A ) HeLa1.2.11 cells transfected with indicated siRNAs were analyzed by Q-FISH using a FITC-labeled telomere PNA probe. DAPI was used to stain the nuclei. The histograms show the distribution of relative telomere length presented as fluorescence intensity (TFU, telomere fluorescence unit); the red lines mark the mean telomere signal intensity. n indicates the total number of telomere signals detected. Error bars indicate standard errors. *** p < 0.001. ( B ) Examples of telomere abnormalities from ( A ) observed in a telomere FISH assay (upper panel). The incidence of telomere abnormalities in cells lacking ESCO1 or ESCO2 is shown in the bottom panel. ( C ) Sankey diagram showing KEGG pathway analysis of high-confidence proteins associated with ESCO2. Pathway enrichment was performed based on high-confidence ESCO2-interacting proteins, and the results are visualized as a Sankey diagram to illustrate the functional distribution across different KEGG pathways. ( D ) Chord diagram showing KEGG pathway analysis of DNA replication- and repair-related pathways and their associated proteins. Diagram visualizes the relationship between key proteins and their corresponding pathways involved in DNA replication and repair. ( E ) Selected lists of ESCO2-associated proteins analyzed by mass spectrometry. ( F ) Western blot performed to determine ESCO2 and <t>BLM</t> siRNA-knockdown efficiency in HeLa1.2.11 cells. ( G ) Representative images of metaphase telomere FISH in cells from ( G ) (upper panel). The incidence of telomere abnormalities is shown in the bottom panel.
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    <t>ESCO2</t> deficiency results in telomere abnormalities. ( A ) HeLa1.2.11 cells transfected with indicated siRNAs were analyzed by Q-FISH using a FITC-labeled telomere PNA probe. DAPI was used to stain the nuclei. The histograms show the distribution of relative telomere length presented as fluorescence intensity (TFU, telomere fluorescence unit); the red lines mark the mean telomere signal intensity. n indicates the total number of telomere signals detected. Error bars indicate standard errors. *** p < 0.001. ( B ) Examples of telomere abnormalities from ( A ) observed in a telomere FISH assay (upper panel). The incidence of telomere abnormalities in cells lacking ESCO1 or ESCO2 is shown in the bottom panel. ( C ) Sankey diagram showing KEGG pathway analysis of high-confidence proteins associated with ESCO2. Pathway enrichment was performed based on high-confidence ESCO2-interacting proteins, and the results are visualized as a Sankey diagram to illustrate the functional distribution across different KEGG pathways. ( D ) Chord diagram showing KEGG pathway analysis of DNA replication- and repair-related pathways and their associated proteins. Diagram visualizes the relationship between key proteins and their corresponding pathways involved in DNA replication and repair. ( E ) Selected lists of ESCO2-associated proteins analyzed by mass spectrometry. ( F ) Western blot performed to determine ESCO2 and <t>BLM</t> siRNA-knockdown efficiency in HeLa1.2.11 cells. ( G ) Representative images of metaphase telomere FISH in cells from ( G ) (upper panel). The incidence of telomere abnormalities is shown in the bottom panel.
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    <t>ESCO2</t> deficiency results in telomere abnormalities. ( A ) HeLa1.2.11 cells transfected with indicated siRNAs were analyzed by Q-FISH using a FITC-labeled telomere PNA probe. DAPI was used to stain the nuclei. The histograms show the distribution of relative telomere length presented as fluorescence intensity (TFU, telomere fluorescence unit); the red lines mark the mean telomere signal intensity. n indicates the total number of telomere signals detected. Error bars indicate standard errors. *** p < 0.001. ( B ) Examples of telomere abnormalities from ( A ) observed in a telomere FISH assay (upper panel). The incidence of telomere abnormalities in cells lacking ESCO1 or ESCO2 is shown in the bottom panel. ( C ) Sankey diagram showing KEGG pathway analysis of high-confidence proteins associated with ESCO2. Pathway enrichment was performed based on high-confidence ESCO2-interacting proteins, and the results are visualized as a Sankey diagram to illustrate the functional distribution across different KEGG pathways. ( D ) Chord diagram showing KEGG pathway analysis of DNA replication- and repair-related pathways and their associated proteins. Diagram visualizes the relationship between key proteins and their corresponding pathways involved in DNA replication and repair. ( E ) Selected lists of ESCO2-associated proteins analyzed by mass spectrometry. ( F ) Western blot performed to determine ESCO2 and <t>BLM</t> siRNA-knockdown efficiency in HeLa1.2.11 cells. ( G ) Representative images of metaphase telomere FISH in cells from ( G ) (upper panel). The incidence of telomere abnormalities is shown in the bottom panel.
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    Image Search Results


    ESCO2 deficiency results in telomere abnormalities. ( A ) HeLa1.2.11 cells transfected with indicated siRNAs were analyzed by Q-FISH using a FITC-labeled telomere PNA probe. DAPI was used to stain the nuclei. The histograms show the distribution of relative telomere length presented as fluorescence intensity (TFU, telomere fluorescence unit); the red lines mark the mean telomere signal intensity. n indicates the total number of telomere signals detected. Error bars indicate standard errors. *** p < 0.001. ( B ) Examples of telomere abnormalities from ( A ) observed in a telomere FISH assay (upper panel). The incidence of telomere abnormalities in cells lacking ESCO1 or ESCO2 is shown in the bottom panel. ( C ) Sankey diagram showing KEGG pathway analysis of high-confidence proteins associated with ESCO2. Pathway enrichment was performed based on high-confidence ESCO2-interacting proteins, and the results are visualized as a Sankey diagram to illustrate the functional distribution across different KEGG pathways. ( D ) Chord diagram showing KEGG pathway analysis of DNA replication- and repair-related pathways and their associated proteins. Diagram visualizes the relationship between key proteins and their corresponding pathways involved in DNA replication and repair. ( E ) Selected lists of ESCO2-associated proteins analyzed by mass spectrometry. ( F ) Western blot performed to determine ESCO2 and BLM siRNA-knockdown efficiency in HeLa1.2.11 cells. ( G ) Representative images of metaphase telomere FISH in cells from ( G ) (upper panel). The incidence of telomere abnormalities is shown in the bottom panel.

    Journal: International Journal of Molecular Sciences

    Article Title: ESCO2 Interacts with TRF1/2 and Facilitates Telomere Maintenance

    doi: 10.3390/ijms27062635

    Figure Lengend Snippet: ESCO2 deficiency results in telomere abnormalities. ( A ) HeLa1.2.11 cells transfected with indicated siRNAs were analyzed by Q-FISH using a FITC-labeled telomere PNA probe. DAPI was used to stain the nuclei. The histograms show the distribution of relative telomere length presented as fluorescence intensity (TFU, telomere fluorescence unit); the red lines mark the mean telomere signal intensity. n indicates the total number of telomere signals detected. Error bars indicate standard errors. *** p < 0.001. ( B ) Examples of telomere abnormalities from ( A ) observed in a telomere FISH assay (upper panel). The incidence of telomere abnormalities in cells lacking ESCO1 or ESCO2 is shown in the bottom panel. ( C ) Sankey diagram showing KEGG pathway analysis of high-confidence proteins associated with ESCO2. Pathway enrichment was performed based on high-confidence ESCO2-interacting proteins, and the results are visualized as a Sankey diagram to illustrate the functional distribution across different KEGG pathways. ( D ) Chord diagram showing KEGG pathway analysis of DNA replication- and repair-related pathways and their associated proteins. Diagram visualizes the relationship between key proteins and their corresponding pathways involved in DNA replication and repair. ( E ) Selected lists of ESCO2-associated proteins analyzed by mass spectrometry. ( F ) Western blot performed to determine ESCO2 and BLM siRNA-knockdown efficiency in HeLa1.2.11 cells. ( G ) Representative images of metaphase telomere FISH in cells from ( G ) (upper panel). The incidence of telomere abnormalities is shown in the bottom panel.

    Article Snippet: The antibodies used in this study were: 53BP1 (NB100-904; Novus Biologicals, Littleton, CO, USA), Flag (F3165; Sigma, St. Louis, MO, USA), BLM (A300-110A, Bethyl, Boston, MA, USA), ESCO2 (ab86003; Abcam, Cambridge, UK), Myc (sc-40; Santa Cruz Biotechnology, Santa Cruz, CA, USA), and vinculin (V9131; Sigma-Aldrich, St. Louis, MO, USA).

    Techniques: Transfection, Labeling, Staining, Fluorescence, Functional Assay, Mass Spectrometry, Western Blot, Knockdown