Journal: Brain
Article Title: Post-mortem evidence of pathogenic angiogenesis and abnormal vascular function in early Alzheimer’s disease
doi: 10.1093/brain/awaf394
Figure Lengend Snippet: Mediators of angiogenesis are dysregulated in early-stage/intermediate pathology Alzheimer's disease. ( A and B ) Levels of endoglin (CD105), a marker of neoangiogenesis, measured first using the angiogenesis proteome profiler and then independently by commercial ELISA kit. Mean and standard error of the mean are shown. * P < 0.05, ** P < 0.01. ( C and D ) Levels of pro-angiogenic ( C ) and anti-angiogenic ( D ) mediators in early-stage/intermediate pathology [Braak tangle stage (BS) III–IV] (blue) and late-stage AD (BSV–VI) (red), relative to the levels in minimal pathology BS0–II cases.
Article Snippet: Fifty-five proteins related to angiogenesis were measured using the Proteome Profiler Human Angiogenesis Array kit (Cat. No. ARY007, R&D systems), in NP40-soluble extracts of the temporal cortex.
Techniques: Marker, Enzyme-linked Immunosorbent Assay