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afatinib  (MedChemExpress)
94
MedChemExpress afatinib
IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
Afatinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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afatinib  (TargetMol)
93
TargetMol afatinib
IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
Afatinib, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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afatinib dimaleate  (MedChemExpress)
94
MedChemExpress afatinib dimaleate
IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
Afatinib Dimaleate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/afatinib dimaleate/product/MedChemExpress
Average 94 stars, based on 1 article reviews
afatinib dimaleate - by Bioz Stars, 2026-05
94/100 stars
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drugs  (MedChemExpress)
94
MedChemExpress drugs
IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
Drugs, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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drugs - by Bioz Stars, 2026-05
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afatinib dimaleate  (Selleck Chemicals)
96
Selleck Chemicals afatinib dimaleate
IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
Afatinib Dimaleate, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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afatinib  (Boehringer Ingelheim)
86
Boehringer Ingelheim afatinib
IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), <t>Afatinib</t> (1 μM) <t>(E),</t> <t>Osimertinib</t> (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.
Afatinib, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), Afatinib (1 μM) (E), Osimertinib (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.

Journal: Redox Biology

Article Title: C-terminal interleukin 1 alpha (IL-1α) overexpression drives EMT and a vulnerability to ferroptosis in HNSCC

doi: 10.1016/j.redox.2026.104172

Figure Lengend Snippet: IL-1α overexpression induces resistance to EGFR tyrosine kinase inhibitors. (A) Whole cell lysates were analyzed for EGFR and phosphorylated EGFR (pEGFR) expression by Western blot in control (CTL) and full-length (FL), N-terminal (NT) and C-terminal (CT) IL-1α overexpressed cells using α-Tubulin as a loading control, with quantification of protein expression shown in B and C. (D-G) Cell viability following 48 h treatment with Erlotinib (5 μM) (D), Afatinib (1 μM) (E), Osimertinib (1 μM) (F) and Silevertinib (1 μM) (G) was measured using MTT assays. Bars represent mean ± SEM from n = 3 independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.

Article Snippet: Afatinib, osimertinib and silivertinib (BDTX-1535) were from MedchemExpress (NJ, USA).

Techniques: Over Expression, Expressing, Western Blot, Control