Journal: Pharmaceutics
Article Title: Plasmid DNA Delivery to Cancer Cells with Poly(L-lysine)-Based Copolymers Bearing Thermally Sensitive Segments: Balancing Polyplex Tightness, Transfection Efficiency, and Biocompatibility
doi: 10.3390/pharmaceutics17081012
Figure Lengend Snippet: Physicochemical characterization results of the polyplexes. ( A ) Representative particle size distribution measured at an angle of 90° for polyplexes of PNL-65 at N/P 12, prepared by method H-C. ( B ) Zimm plot of polyplexes of PNL-20 at N/P 18, prepared by method H: experimental points (open symbols); extrapolated points to zero concentration and zero scattering angle (closed symbols). ( C ) Representative AFM micrographs of the polyplex particles prepared with PNL-10 at N/P 12, using method H. ( D ) Variations of hydrodynamic diameters and ( E ) ζ potential values of polyplex particles of PNL-10, PNL-20, PNL-37, and PNL-65 with N/P. The polyplexes were prepared by the method RT. Measurements were performed at 25 °C.
Article Snippet: The SLS data were analyzed using the Zimm plot software provided by Brookhaven Instruments.
Techniques: Concentration Assay