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zdevd-fmk  (Bachem)

 
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    Bachem zdevd-fmk
    Zdevd Fmk, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/z+devd+fmk+zdevd/z+devd+fmk/pm12934070-134-8-35
    Average 90 stars, based on 1 article reviews
    zdevd-fmk - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    other:

    Article Title: Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion
    Article Snippet: In some cases, the caspase-3 inhibitor Ac-DEVD-fmk (Bachem; 100 μ m ) was added to cell cultures as described ( 27 ).

    Article Title: Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients
    Article Snippet: When indicated, monocytes were treated with colchicine (1 μM or at the indicated concentration, Sigma), MCC950 (10 μM, Adipogen AG‐CR1‐3615), paclitaxel (Taxol, 5 μM, Sigma), nocodazole (5 μM, Sigma), z‐YVAD‐FMK, z‐IETD‐FMK, z‐DEVD‐FMK (at the indicated concentrations, Bachem, #4027532, #4034771, #4027402, respectively), VX‐765 (InvivoGen), 30 min before addition of UCN‐01, TcdB (Abcam, #ab124001, 125 ng/ml), and TcdA (1 μg/ml) or nigericin.

    Article Title: Megakaryocytic particles and microparticles for in vivo hematopoietic cell and gene therapies
    Article Snippet: DNA Synthesis Assay: DNA synthesis was assessed using a BrdU APC flow kit (BD Bioscience).

    Article Title: Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity
    Article Snippet: The Cell Death Detection enzyme-linked immunosorbent (ELISA) Plus assay kit was purchased from Roche Molecular Biochemicals (Indianapolis, Indiana).

    Article Title: Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis
    Article Snippet: Z-DEVD-fmk and Z-VAD-fmk, two caspase 3 inhibitors, were obtained from Bachem.

    Article Title: Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo
    Article Snippet: The cathepsin and caspase inhibitors used were z-FA-FMK (cathepsin B, L and S), Ca-074-Me (irreversible capthepsin B inhibitor), z-DEVD-FMK (caspase 3 and 7), and z-DEVD-CMK (caspase 3), all from Bachem.

    Article Title: Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells
    Article Snippet: For caspase inhibition experiments, Mks were treated with caspase inhibitors, 10 μM z-VAD.fmk (Bachem) or 10 μM z-DEVD.fmk (Bachem) starting on day 9.



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    Detection of apoptosis-related factors in NHEK cell lysates following sorafenib and antifungal drug treatment. Detection of (A) cIAP-1 (70 kDa) and (C) cleaved caspase-3 (19 kDa) in the cell lysate was performed using western blotting. (B) Bands were semi-quantified using ImageJ, and data were expressed as the relative ratio of cIAP-1/β-actin. Statistical analysis was conducted using one-way ANOVA followed by Tukey’s test; ns indicates not significant. Sora or S: sorafenib, Keto: ketoconazole, Itra: itraconazole. All results are presented as the mean ± SD of triplicate experiments. (D) Various concentrations of sorafenib, with or without 50 μmM ZVAD or <t>ZDEVD,</t> were added to cultured NHEK cells. DMSO was used as the solvent for both sorafenib and the inhibitors. After overnight incubation, cell viability was assessed using the cell-counting kit-8 assay. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s test; ** p < 0.01 and * p < 0.05 (vs DMSO (-)).
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    Detection of apoptosis-related factors in NHEK cell lysates following sorafenib and antifungal drug treatment. Detection of (A) cIAP-1 (70 kDa) and (C) cleaved caspase-3 (19 kDa) in the cell lysate was performed using western blotting. (B) Bands were semi-quantified using ImageJ, and data were expressed as the relative ratio of cIAP-1/β-actin. Statistical analysis was conducted using one-way ANOVA followed by Tukey’s test; ns indicates not significant. Sora or S: sorafenib, Keto: ketoconazole, Itra: itraconazole. All results are presented as the mean ± SD of triplicate experiments. (D) Various concentrations of sorafenib, with or without 50 μmM ZVAD or ZDEVD, were added to cultured NHEK cells. DMSO was used as the solvent for both sorafenib and the inhibitors. After overnight incubation, cell viability was assessed using the cell-counting kit-8 assay. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s test; ** p < 0.01 and * p < 0.05 (vs DMSO (-)).

    Journal: Acta Dermato-Venereologica

    Article Title: Possible Clinical Effects of Ketoconazole on Sorafenib-induced Hand–Foot Skin Reaction and Cytoprotection Mechanisms of Antifungal Agents against Multikinase Inhibitor-induced Keratinocyte Toxicity

    doi: 10.2340/actadv.v105.40697

    Figure Lengend Snippet: Detection of apoptosis-related factors in NHEK cell lysates following sorafenib and antifungal drug treatment. Detection of (A) cIAP-1 (70 kDa) and (C) cleaved caspase-3 (19 kDa) in the cell lysate was performed using western blotting. (B) Bands were semi-quantified using ImageJ, and data were expressed as the relative ratio of cIAP-1/β-actin. Statistical analysis was conducted using one-way ANOVA followed by Tukey’s test; ns indicates not significant. Sora or S: sorafenib, Keto: ketoconazole, Itra: itraconazole. All results are presented as the mean ± SD of triplicate experiments. (D) Various concentrations of sorafenib, with or without 50 μmM ZVAD or ZDEVD, were added to cultured NHEK cells. DMSO was used as the solvent for both sorafenib and the inhibitors. After overnight incubation, cell viability was assessed using the cell-counting kit-8 assay. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s test; ** p < 0.01 and * p < 0.05 (vs DMSO (-)).

    Article Snippet: Z-DEVD-FMK (ZDEVD) and Z-VAD-FMK (ZVAD) were from Selleck Chemicals (Houston, TX, USA).

    Techniques: Western Blot, Cell Culture, Solvent, Incubation, Cell Counting