web-based graphical user interface (gui) of dockingserver (Virtua Drug)
90
Structured Review
Virtua Drug
web-based graphical user interface (gui) of dockingserver
Web Based Graphical User Interface (Gui) Of Dockingserver, supplied by Virtua Drug, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/web-based+graphical+user+interface/dockingserver/pmc04775997-135-12-14
Average 90 stars, based on 1 article reviews
Web Based Graphical User Interface (Gui) Of Dockingserver, supplied by Virtua Drug, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/web-based+graphical+user+interface/dockingserver/pmc04775997-135-12-14
Average 90 stars, based on 1 article reviews
web-based graphical user interface (gui) of dockingserver - by Bioz Stars,
2026-11
90/100 stars
Images
1) Product Images from "Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development"
Article Title: Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
Journal: Antimicrobial Agents and Chemotherapy
doi: 10.1128/AAC.01748-15
Figure Legend Snippet: Affinity purification of cellular targets of compound D. (A) Biotin linked to the R1 group of compound D. This compound was bound to streptavidin-agarose and used to affinity purify proteins from a trophozoite cell lysate. The only significant hit identified by LC-MS/MS was HSP90 (see Table S3 in the supplemental material). (B) Predicted interactions between compound D and PfHSP90. (C) Modeling of the most likely binding orientation of compound D to the ATP binding site of HSP90 was carried out using DockingServer. Residues predicted to form hydrogen bonds with compound D are labeled in green, while those predicted to form hydrophobic interactions are labeled in blue. (D) Recombinant PfHSP90 binds to compound D. Purified recombinant PfHSP90 and PfHSP90-NTD used in subsequent experiments are shown in the Coomassie-stained gels to the left of the figure. Changes in the tryptophan fluorescence (346 nm) of PfHSP90 were monitored in the presence of increasing amounts of compound D or 17-AAG. K d values were calculated for both full-length (FL) PfHSP90 and PfHSP90-NTD. Values in brackets are the standard errors (SE) of the means of triplicate measurements.
Techniques Used: Affinity Purification, Liquid Chromatography with Mass Spectroscopy, Binding Assay, Labeling, Recombinant, Purification, Staining, Fluorescence
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