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Structured Review

10X Genomics visium dataset
a – d , Spatial expression (log 2 FC) of CDH5 (pan-EC marker), SEMA3G and GJA5 (arterial EC markers) ( a ), ACKR1 and PLVAP (venous EC markers) ( b ), MYH11 and ACTA2 (pan-SMC markers) ( c ), and JAG1 and NOTCH2 ( d ) on publicly <t>available</t> <t>10X</t> <t>Visium</t> section of human left ventricle. JAG1 and NOTCH2 are the predicted interaction partners for arterial ECs and SMCs, respectively.
Visium Dataset, supplied by 10X Genomics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/visium+image+alignment+function/pmc07681775-401-29-27?v=10X+Genomics
Average 86 stars, based on 1 article reviews
visium dataset - by Bioz Stars, 2026-08
86/100 stars

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1) Product Images from "Cells of the adult human heart"

Article Title: Cells of the adult human heart

Journal: Nature

doi: 10.1038/s41586-020-2797-4

a – d , Spatial expression (log 2 FC) of CDH5 (pan-EC marker), SEMA3G and GJA5 (arterial EC markers) ( a ), ACKR1 and PLVAP (venous EC markers) ( b ), MYH11 and ACTA2 (pan-SMC markers) ( c ), and JAG1 and NOTCH2 ( d ) on publicly available 10X Visium section of human left ventricle. JAG1 and NOTCH2 are the predicted interaction partners for arterial ECs and SMCs, respectively.
Figure Legend Snippet: a – d , Spatial expression (log 2 FC) of CDH5 (pan-EC marker), SEMA3G and GJA5 (arterial EC markers) ( a ), ACKR1 and PLVAP (venous EC markers) ( b ), MYH11 and ACTA2 (pan-SMC markers) ( c ), and JAG1 and NOTCH2 ( d ) on publicly available 10X Visium section of human left ventricle. JAG1 and NOTCH2 are the predicted interaction partners for arterial ECs and SMCs, respectively.

Techniques Used: Expressing, Marker

a , Visualization of transcriptional signatures from published studies. The score values represent the likelihood of the external transcriptional signature to be present when comparing it against the transcriptional background of a cardiac immune population. Bajpai_2018 = CCR2 - MERTK + tissue-resident macrophages from ref. . Dick_2019 = self-renewing tissue macrophages from ref. . Bian_2020 = yolk sac-derived macrophages from ref. . The complete signature can be found in Supplementary Table . b , Expression (log 2 FC) of LYVE1 , FOLR2 and TIMD4 characteristic of the self-renewing tissue-resident murine macrophages previously described , as well as MERTK as previously described and the TREM2 expression associated to lipid-associated macrophages (LAM) previously described . Complete signatures can be found in Supplementary Table . c , Scaled expression (log 2 FC) of genes differentiating DOCK4 + MP1 from DOCK4 + MP2: IL4R , ITGAM , STAT3 , DOCK1 , HIF1A and RASA2 . d , Predicted cell–cell interactions calculated for 69,295 cardiomyocytes, fibroblasts and myeloid cells from 14 donors ( n = 14) and enriched for ‘extracellular matrix organization’. Mean of combined gene expression of interacting pairs (log 2 FC). Data are available in Supplementary Table . e , Spatial mapping of the CD74 – MIF interaction between LYVE1 + MP and FB4 on a publicly available 10X Genomics Visium dataset for left ventricular myocardium. We identified four spots where we observe co-expression of FN1 , LYVE1 , CD74 and MIF , as predicted from the cell–cell interactions. The bar represents the log 2 FC. f , Confusion matrix for the logistic regression model trained on cardiac immune cells. This model reached an accuracy score of 0.6862, showing a stronger accuracy with lymphoid cells, compared with the myeloid ones.
Figure Legend Snippet: a , Visualization of transcriptional signatures from published studies. The score values represent the likelihood of the external transcriptional signature to be present when comparing it against the transcriptional background of a cardiac immune population. Bajpai_2018 = CCR2 - MERTK + tissue-resident macrophages from ref. . Dick_2019 = self-renewing tissue macrophages from ref. . Bian_2020 = yolk sac-derived macrophages from ref. . The complete signature can be found in Supplementary Table . b , Expression (log 2 FC) of LYVE1 , FOLR2 and TIMD4 characteristic of the self-renewing tissue-resident murine macrophages previously described , as well as MERTK as previously described and the TREM2 expression associated to lipid-associated macrophages (LAM) previously described . Complete signatures can be found in Supplementary Table . c , Scaled expression (log 2 FC) of genes differentiating DOCK4 + MP1 from DOCK4 + MP2: IL4R , ITGAM , STAT3 , DOCK1 , HIF1A and RASA2 . d , Predicted cell–cell interactions calculated for 69,295 cardiomyocytes, fibroblasts and myeloid cells from 14 donors ( n = 14) and enriched for ‘extracellular matrix organization’. Mean of combined gene expression of interacting pairs (log 2 FC). Data are available in Supplementary Table . e , Spatial mapping of the CD74 – MIF interaction between LYVE1 + MP and FB4 on a publicly available 10X Genomics Visium dataset for left ventricular myocardium. We identified four spots where we observe co-expression of FN1 , LYVE1 , CD74 and MIF , as predicted from the cell–cell interactions. The bar represents the log 2 FC. f , Confusion matrix for the logistic regression model trained on cardiac immune cells. This model reached an accuracy score of 0.6862, showing a stronger accuracy with lymphoid cells, compared with the myeloid ones.

Techniques Used: Derivative Assay, Expressing



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