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platform utilized ultrahigh performance liquid chromatography tandem mass spectroscopy  (Metabolon Inc)

 
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    Structured Review

    Metabolon Inc platform utilized ultrahigh performance liquid chromatography tandem mass spectroscopy
    Platform Utilized Ultrahigh Performance Liquid Chromatography Tandem Mass Spectroscopy, supplied by Metabolon Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/utility/chromatography+liquid+mass+performance+spectroscopy+tandem+ultrahigh/pmc13244126-64-2-1
    Average 86 stars, based on 1 article reviews
    platform utilized ultrahigh performance liquid chromatography tandem mass spectroscopy - by Bioz Stars, 2026-10
    86/100 stars

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    Related Articles

    Clinical Proteomics:

    Article Title: Association of age-related macular degeneration with exposome related metabolomics
    Article Snippet: .. Fasting plasma and urine samples were used for metabolomic profiling using Ultrahigh Performance Liquid Chromatography – Mass Spectrometry (Metabolon, Inc). ..

    Article Title: Metabolic heterogeneity and niche rewiring in bone marrow plasma cells from patients with MGUS, solitary bone plasmacytoma and multiple myeloma.
    Article Snippet: .. LC-MS assessment of bone marrow plasma Bone marrow plasma samples were subjected to global untargeted metabolomic profiling by Metabolon, Inc. using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS), as previously described. ..

    Article Title: Contrasting dietary patterns remodel gut microbial function and generate multi-omic signatures associated with cardiometabolic markers.
    Article Snippet: .. Plasma and urine metabolomic profiling was conducted by Metabolon Inc. (Morrisville, USA) using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) via their Global Discovery Panel. ..

    Article Title: Associations between diet, metabolome, gut microbiota and blood pressure in Australian adults.
    Article Snippet: .. Metabolite profiling of plasma and urine was performed by Metabolon Inc (Morrisville, NC, USA) using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) as part of their Global Discovery Panel(20). .. Gut microbiota ACCEPTED MANUSCRIPT AR TIC LE IN PR ES S ARTICLE IN PRESS Faecal samples were collected within 3 days of individual clinic appointments using athome collection kits, using Zymo Research FecesCatcher catchment paper(21) and DNA/RNA ShieldTM faecal collection tubes(22).

    Metabolomic:

    Article Title: Association of age-related macular degeneration with exposome related metabolomics
    Article Snippet: .. Fasting plasma and urine samples were used for metabolomic profiling using Ultrahigh Performance Liquid Chromatography – Mass Spectrometry (Metabolon, Inc). ..

    Article Title: Metabolic heterogeneity and niche rewiring in bone marrow plasma cells from patients with MGUS, solitary bone plasmacytoma and multiple myeloma.
    Article Snippet: .. LC-MS assessment of bone marrow plasma Bone marrow plasma samples were subjected to global untargeted metabolomic profiling by Metabolon, Inc. using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS), as previously described. ..

    Article Title: Contrasting dietary patterns remodel gut microbial function and generate multi-omic signatures associated with cardiometabolic markers.
    Article Snippet: .. Plasma and urine metabolomic profiling was conducted by Metabolon Inc. (Morrisville, USA) using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) via their Global Discovery Panel. ..

    Liquid Chromatography:

    Article Title: Association of age-related macular degeneration with exposome related metabolomics
    Article Snippet: .. Fasting plasma and urine samples were used for metabolomic profiling using Ultrahigh Performance Liquid Chromatography – Mass Spectrometry (Metabolon, Inc). ..

    Mass Spectrometry:

    Article Title: Association of age-related macular degeneration with exposome related metabolomics
    Article Snippet: .. Fasting plasma and urine samples were used for metabolomic profiling using Ultrahigh Performance Liquid Chromatography – Mass Spectrometry (Metabolon, Inc). ..

    Article Title: CPT1A loss promotes lung metastasis in immune-competent mice via a mechanism of mtDNA release and chronic activation of STING pathway
    Article Snippet: .. Cell pellets of control (sgNTC) or Cpt1a-KO (sgCpt1a) 4T1 cells (n=6 per sample) were analyzed by Metabolon using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), as previously described . ..

    Article Title: Carbohydrate Metabolism Differs in Infants by Asthma-risk Status and is Associated with the Functional Potential of Bacteroides cellulosilyticus
    Article Snippet: .. Briefly, 200 mg of stool samples from patients collected at 6 months (n=15 HC, n=11 HR) underwent ultrahigh performance liquid chromatography/tandem mass spectrometry (UPLC–MS/MS) and gas chromatography–mass spectrometry (GC–MS) by Metabolon (Durham, NC), using their standard protocol ( http://www.metabolon.com/ ). .. Compounds were compared to Metabolon’s in-house library of purified standards, which includes more than 3,300 commercially available compounds.

    Article Title: The 2R, 3R isomer of 2, 3-butanediol prevents weight gain and decreases plasma glucose concentration of mice fed a fat-enriched diet
    Article Snippet: Samples were immediately frozen on solid CO 2 and stored at -80 °C until being shipped on solid CO 2 to Metabolon (Morrisville, NC, USA) for global liver biochemical profiling. .. The Metabolon platform utilized Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectroscopy (UPLC-MS/MS). .. Namely, a Waters ACQUITY ultra-performance liquid chromatography (UPLC) and a Thermo Scientific Q-Exactive high resolution/accurate mass spectrometer interfaced with a heated electrospray ionization (HESI-II) source and Orbitrap mass analyzer, operated at 35, 000 mass resolution.

    Article Title: Metabolic heterogeneity and niche rewiring in bone marrow plasma cells from patients with MGUS, solitary bone plasmacytoma and multiple myeloma.
    Article Snippet: .. LC-MS assessment of bone marrow plasma Bone marrow plasma samples were subjected to global untargeted metabolomic profiling by Metabolon, Inc. using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS), as previously described. ..

    Article Title: Contrasting dietary patterns remodel gut microbial function and generate multi-omic signatures associated with cardiometabolic markers.
    Article Snippet: .. Plasma and urine metabolomic profiling was conducted by Metabolon Inc. (Morrisville, USA) using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) via their Global Discovery Panel. ..

    Article Title: Associations between diet, metabolome, gut microbiota and blood pressure in Australian adults.
    Article Snippet: .. Metabolite profiling of plasma and urine was performed by Metabolon Inc (Morrisville, NC, USA) using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) as part of their Global Discovery Panel(20). .. Gut microbiota ACCEPTED MANUSCRIPT AR TIC LE IN PR ES S ARTICLE IN PRESS Faecal samples were collected within 3 days of individual clinic appointments using athome collection kits, using Zymo Research FecesCatcher catchment paper(21) and DNA/RNA ShieldTM faecal collection tubes(22).

    Article Title: Fatty acid amide hydrolase inhibition for treatment of amyotrophic lateral sclerosis.
    Article Snippet: .. Serum samples 459 were centrifuged at 3000 rpm for 10 min and stored at –80 °C until processing at Metabolon 460 Inc. and Shimadzu Techno-Research, Inc. 461 Metabolomics analysis 462 Untargeted metabolomics profiling of serum samples was performed using ultrahigh-463 performance liquid chromatography-tandem mass spectrometry (UPLC‒MS/MS) by 464 Metabolon, inc. To remove protein, dissociate small molecules bound to protein or trapped in 465 the precipitated protein matrix and to recover chemically diverse metabolites, proteins were 466 precipitated with methanol. ..

    Control:

    Article Title: CPT1A loss promotes lung metastasis in immune-competent mice via a mechanism of mtDNA release and chronic activation of STING pathway
    Article Snippet: .. Cell pellets of control (sgNTC) or Cpt1a-KO (sgCpt1a) 4T1 cells (n=6 per sample) were analyzed by Metabolon using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), as previously described . ..

    Chromatography:

    Article Title: CPT1A loss promotes lung metastasis in immune-competent mice via a mechanism of mtDNA release and chronic activation of STING pathway
    Article Snippet: .. Cell pellets of control (sgNTC) or Cpt1a-KO (sgCpt1a) 4T1 cells (n=6 per sample) were analyzed by Metabolon using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), as previously described . ..

    Article Title: Carbohydrate Metabolism Differs in Infants by Asthma-risk Status and is Associated with the Functional Potential of Bacteroides cellulosilyticus
    Article Snippet: .. Briefly, 200 mg of stool samples from patients collected at 6 months (n=15 HC, n=11 HR) underwent ultrahigh performance liquid chromatography/tandem mass spectrometry (UPLC–MS/MS) and gas chromatography–mass spectrometry (GC–MS) by Metabolon (Durham, NC), using their standard protocol ( http://www.metabolon.com/ ). .. Compounds were compared to Metabolon’s in-house library of purified standards, which includes more than 3,300 commercially available compounds.

    Article Title: The 2R, 3R isomer of 2, 3-butanediol prevents weight gain and decreases plasma glucose concentration of mice fed a fat-enriched diet
    Article Snippet: Samples were immediately frozen on solid CO 2 and stored at -80 °C until being shipped on solid CO 2 to Metabolon (Morrisville, NC, USA) for global liver biochemical profiling. .. The Metabolon platform utilized Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectroscopy (UPLC-MS/MS). .. Namely, a Waters ACQUITY ultra-performance liquid chromatography (UPLC) and a Thermo Scientific Q-Exactive high resolution/accurate mass spectrometer interfaced with a heated electrospray ionization (HESI-II) source and Orbitrap mass analyzer, operated at 35, 000 mass resolution.

    Article Title: Metabolic heterogeneity and niche rewiring in bone marrow plasma cells from patients with MGUS, solitary bone plasmacytoma and multiple myeloma.
    Article Snippet: .. LC-MS assessment of bone marrow plasma Bone marrow plasma samples were subjected to global untargeted metabolomic profiling by Metabolon, Inc. using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS), as previously described. ..

    Article Title: Contrasting dietary patterns remodel gut microbial function and generate multi-omic signatures associated with cardiometabolic markers.
    Article Snippet: .. Plasma and urine metabolomic profiling was conducted by Metabolon Inc. (Morrisville, USA) using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) via their Global Discovery Panel. ..

    Article Title: Associations between diet, metabolome, gut microbiota and blood pressure in Australian adults.
    Article Snippet: .. Metabolite profiling of plasma and urine was performed by Metabolon Inc (Morrisville, NC, USA) using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) as part of their Global Discovery Panel(20). .. Gut microbiota ACCEPTED MANUSCRIPT AR TIC LE IN PR ES S ARTICLE IN PRESS Faecal samples were collected within 3 days of individual clinic appointments using athome collection kits, using Zymo Research FecesCatcher catchment paper(21) and DNA/RNA ShieldTM faecal collection tubes(22).

    Article Title: Fatty acid amide hydrolase inhibition for treatment of amyotrophic lateral sclerosis.
    Article Snippet: .. Serum samples 459 were centrifuged at 3000 rpm for 10 min and stored at –80 °C until processing at Metabolon 460 Inc. and Shimadzu Techno-Research, Inc. 461 Metabolomics analysis 462 Untargeted metabolomics profiling of serum samples was performed using ultrahigh-463 performance liquid chromatography-tandem mass spectrometry (UPLC‒MS/MS) by 464 Metabolon, inc. To remove protein, dissociate small molecules bound to protein or trapped in 465 the precipitated protein matrix and to recover chemically diverse metabolites, proteins were 466 precipitated with methanol. ..

    Gas Chromatography-Mass Spectrometry:

    Article Title: Carbohydrate Metabolism Differs in Infants by Asthma-risk Status and is Associated with the Functional Potential of Bacteroides cellulosilyticus
    Article Snippet: .. Briefly, 200 mg of stool samples from patients collected at 6 months (n=15 HC, n=11 HR) underwent ultrahigh performance liquid chromatography/tandem mass spectrometry (UPLC–MS/MS) and gas chromatography–mass spectrometry (GC–MS) by Metabolon (Durham, NC), using their standard protocol ( http://www.metabolon.com/ ). .. Compounds were compared to Metabolon’s in-house library of purified standards, which includes more than 3,300 commercially available compounds.

    Liquid Chromatography with Mass Spectroscopy:

    Article Title: Metabolic heterogeneity and niche rewiring in bone marrow plasma cells from patients with MGUS, solitary bone plasmacytoma and multiple myeloma.
    Article Snippet: .. LC-MS assessment of bone marrow plasma Bone marrow plasma samples were subjected to global untargeted metabolomic profiling by Metabolon, Inc. using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS), as previously described. ..



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    Image Search Results


    a was created by Figdraw. a , b Treatment schedule of the GL261 mouse brain tumor model (by figdraw.com). The detailed treatment sequence and time points. c , d Brain images of each group of mice obtained by T2 magnetic resonance imaging (MRI) with different treatments, where tumors are circled in white dashed lines. e-g Immunohistochemical images of tumor sections were examined at 15 days (Ki67 and PCNA, n = 5). h Survival curves of GBM tumor-bearing mice in different treatment groups ( n = 10). Survival analysis was calculated using the log-rank test. i Body weight changes of GBM tumor-bearing mice in different treatment groups ( n = 10). j , k Evaluation of antitumor effects of different treatments. n = 5 samples per group for data in ( c-f ) and ( i-k ). Data are expressed as the mean ± SD. Statistical significances were determined using one-way ANOVA with Fisher’s LSD post‑hoc test. Comparisons were performed between different groups in ( c-f ) and ( i-k ). Not significant (NS) is P ≥ 0.05, and significant P values are shown. n = 10 samples per group for data in ( h ). Survival analysis was compared using the log-rank test. Source data are provided as a file.

    Journal: Nature Communications

    Article Title: Low-intensity pulsed ultrasound-mediated nose-to-brain co-delivery of β-blockers and aPD-L1 enhances glioblastoma immunotherapy

    doi: 10.1038/s41467-026-76103-4

    Figure Lengend Snippet: a was created by Figdraw. a , b Treatment schedule of the GL261 mouse brain tumor model (by figdraw.com). The detailed treatment sequence and time points. c , d Brain images of each group of mice obtained by T2 magnetic resonance imaging (MRI) with different treatments, where tumors are circled in white dashed lines. e-g Immunohistochemical images of tumor sections were examined at 15 days (Ki67 and PCNA, n = 5). h Survival curves of GBM tumor-bearing mice in different treatment groups ( n = 10). Survival analysis was calculated using the log-rank test. i Body weight changes of GBM tumor-bearing mice in different treatment groups ( n = 10). j , k Evaluation of antitumor effects of different treatments. n = 5 samples per group for data in ( c-f ) and ( i-k ). Data are expressed as the mean ± SD. Statistical significances were determined using one-way ANOVA with Fisher’s LSD post‑hoc test. Comparisons were performed between different groups in ( c-f ) and ( i-k ). Not significant (NS) is P ≥ 0.05, and significant P values are shown. n = 10 samples per group for data in ( h ). Survival analysis was compared using the log-rank test. Source data are provided as a file.

    Article Snippet: Immunohistochemical staining utilized PCNA (AC058, PCNA Mouse mAb, Abclonal) and Ki67 (A26755PM, Ki67 Rabbit PolymAb®, Abclonal) antibodies, with technical assistance from Nanjing Youmeng Biotechnology Co., Ltd. Tumor sections underwent immunofluorescence staining using a TUNEL assay kit (Beyotime Biotech, Shanghai, China).

    Techniques: Sequencing, Magnetic Resonance Imaging, Immunohistochemical staining