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leica dm6 upright microscope  (Danaher Inc)


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    Structured Review

    Danaher Inc leica dm6 upright microscope
    Leica Dm6 Upright Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 742 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/upright+microscope/Leica+DM6+B+Upright+Microscopes/pmc09412956-208-5-5
    Average 96 stars, based on 742 article reviews
    leica dm6 upright microscope - by Bioz Stars, 2026-11
    96/100 stars

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    Related Articles

    Incubation:

    Article Title: Integrating scRNA-Seq and Spatial Transcriptomics Reveal Novel Risk Stratification Signatures in Cervical Carcinoma.
    Article Snippet: Cervical cancer is the fourth most common malignancy in women worldwide.. Biomarker‐assisted screening may improve diagnostic accuracy, but biomarkers predicting progression of low‐grade squamous intraepithelial lesions (LSIL) remain limited.. We integrated single‐cell RNA sequencing and spatial transcriptomics to identify prognostic biomarkers associated with LSIL outcomes, followed by validation using improved in situ sequencing (IISS).

    Article Title: Cell-surface redox regulation coordinates chemotropism and hyphal fusion for root colonization in a vascular wilt pathogen.
    Article Snippet: .. Aliquots of 50 μL were spread onto water agar (2% w/v; 25 mM NaNO3) and incubated at 28◦C for 14–16 h. Anastomosis bridges and cytoplasmic mixing were assessed by epifluorescence microscopy at 63 × (Leica THUNDER Imager 3D, DM6 B upright, K5 sCMOS camera; Leica Microsystems, Milan, Italy); images were processed in LAS X and Fiji (Schindelin et al., 2012). ..

    Fluorescence:

    Article Title: Integrating scRNA-Seq and Spatial Transcriptomics Reveal Novel Risk Stratification Signatures in Cervical Carcinoma.
    Article Snippet: Cervical cancer is the fourth most common malignancy in women worldwide.. Biomarker‐assisted screening may improve diagnostic accuracy, but biomarkers predicting progression of low‐grade squamous intraepithelial lesions (LSIL) remain limited.. We integrated single‐cell RNA sequencing and spatial transcriptomics to identify prognostic biomarkers associated with LSIL outcomes, followed by validation using improved in situ sequencing (IISS).

    Article Title: The hypothalamic orexin–medial prefrontal cortex pathway modulates susceptibility to depression in the learned helplessness paradigm in male mice
    Article Snippet: Sections were then mounted on glass slides, counterstained with 4',6-diamidino-2-202 phenylindole (DAPI, Cat# 0100-20, Southern Biotech, USA) and cover-slipped for imaging. .. 203 Fluorescence images were acquired using a high-resolution fluorescence microscope (DM6 B, 204 Leica, Germany). ..

    Microscopy:

    Article Title: Integrating scRNA-Seq and Spatial Transcriptomics Reveal Novel Risk Stratification Signatures in Cervical Carcinoma.
    Article Snippet: Cervical cancer is the fourth most common malignancy in women worldwide.. Biomarker‐assisted screening may improve diagnostic accuracy, but biomarkers predicting progression of low‐grade squamous intraepithelial lesions (LSIL) remain limited.. We integrated single‐cell RNA sequencing and spatial transcriptomics to identify prognostic biomarkers associated with LSIL outcomes, followed by validation using improved in situ sequencing (IISS).

    Article Title: The hypothalamic orexin–medial prefrontal cortex pathway modulates susceptibility to depression in the learned helplessness paradigm in male mice
    Article Snippet: Sections were then mounted on glass slides, counterstained with 4',6-diamidino-2-202 phenylindole (DAPI, Cat# 0100-20, Southern Biotech, USA) and cover-slipped for imaging. .. 203 Fluorescence images were acquired using a high-resolution fluorescence microscope (DM6 B, 204 Leica, Germany). ..

    Article Title: Targeting V-ATPase assembly via sEVs-delivered doxorubicin triggers methuosis and circumvents temozolomide resistance in glioblastoma.
    Article Snippet: Aim: Temozolomide (TMZ) resistance remains a major challenge in glioblastoma (GBM).. Whether lysosomal alterations represent a targetable vulnerability in TMZ-resistant GBM (TR-GBM) is unclear.. This study investigates whether small extracellular vesicles (sEVs) can reprogram doxorubicin (DOX) subcellular trafficking to exploit lysosomal vulnerabilities and circumvent resistance.

    Article Title: Virulence mechanisms of Desulfovibrio bacteria: viability-dependent processes promote alpha-synuclein aggregation and toxicity in C. elegans.
    Article Snippet: After one minute, a coverslip was placed on top of the agarose pad and sealed with CoverGrip Coverslip Sealant (Biotium, Fremont, CA, USA). .. Imaging was performed using a fully motorized Leica DM6 upright microscope at a high magnification (63x objective) and 488 nm blue laser. ..

    Epifluorescence Microscopy:

    Article Title: Cell-surface redox regulation coordinates chemotropism and hyphal fusion for root colonization in a vascular wilt pathogen.
    Article Snippet: .. Aliquots of 50 μL were spread onto water agar (2% w/v; 25 mM NaNO3) and incubated at 28◦C for 14–16 h. Anastomosis bridges and cytoplasmic mixing were assessed by epifluorescence microscopy at 63 × (Leica THUNDER Imager 3D, DM6 B upright, K5 sCMOS camera; Leica Microsystems, Milan, Italy); images were processed in LAS X and Fiji (Schindelin et al., 2012). ..

    Confocal:

    Article Title: Targeting V-ATPase assembly via sEVs-delivered doxorubicin triggers methuosis and circumvents temozolomide resistance in glioblastoma.
    Article Snippet: Aim: Temozolomide (TMZ) resistance remains a major challenge in glioblastoma (GBM).. Whether lysosomal alterations represent a targetable vulnerability in TMZ-resistant GBM (TR-GBM) is unclear.. This study investigates whether small extracellular vesicles (sEVs) can reprogram doxorubicin (DOX) subcellular trafficking to exploit lysosomal vulnerabilities and circumvent resistance.

    Imaging:

    Article Title: Virulence mechanisms of Desulfovibrio bacteria: viability-dependent processes promote alpha-synuclein aggregation and toxicity in C. elegans.
    Article Snippet: After one minute, a coverslip was placed on top of the agarose pad and sealed with CoverGrip Coverslip Sealant (Biotium, Fremont, CA, USA). .. Imaging was performed using a fully motorized Leica DM6 upright microscope at a high magnification (63x objective) and 488 nm blue laser. ..

    other:

    Article Title: Reprogramming microglia via ShK-modified extracellular vesicles promotes immunomodulation and functional recovery after spinal cord injury.
    Article Snippet: Fluorescence images were acquired using the same microscope (Leica DM6B).

    Article Title: The PIEZO1/CISD1/IP3R Mechanotransduction Axis Drives Macrophage Mitochondrial Dysfunction and Inflammatory Activation in Pulmonary Fibrosis
    Article Snippet: Images were obtained under a fluorescence microscope (DM6B, Leica, Germany).

    Article Title: BATF condensation drives gastric cancer metastasis via chromatin association and transcriptional regulation.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER cell lines ChIP-seq raw sequencing data Genome Sequence Archive of the National Genomics Data Center GSA-human: HRA012844 cell lines RNA-seq raw sequencing data Genome Sequence Archive of the National Genomics Data Center GSA-human: HRA012842 gastric tissues ATAC-seq processed data OMIX repository OMIX: OMIX013676 gastric tissues RNA-seq processed data OMIX repository OMIX: OMIX013682 cell lines ATAC-seq processed data OMIX repository OMIX: OMIX013673 cell lines ChIP-seq processed data OMIX repository OMIX: OMIX013677 cell lines RNA-seq processed data OMIX repository OMIX: OMIX013683 Experimental models: Cell lines AGS cell line Cell Bank of the Chinese Academy of Sciences in Shanghai Cat# TCHu232 MKN45 cell line Cell Bank of the Chinese Academy of Sciences in Shanghai Cat# SCSP-5473 GES-1 cell line Shanghai Zhong Qiao Xin Zhou Biotechnology company Cat# ZQ0905 HEK-293T cell line ATCC Cat# CRL-3216 Sf9 cells ATCC Cat# CRL-1711 High FiveTM Sinobiological company N/A Experimental models: Organisms/strains M-NSG mice Shanghai Model Organisms Center, Inc Cat# NM_NSG-001 Oligonucleotides Oligonucleotide sequence for knockdown, RTqPCR or CUT&RUN-qPCR, EMSA or droplet formation assay and plasmids constructs This Paper Table S1 Software and algorithms Genrich github https://github.com/jsh58/Genrich HINT N/A https://reg-gen.readthedocs.io/en/latest/ hint/introduction.html HOMER 4.1.1 Benner Lab https://homer.ucsd.edu/homer/ nf-core pipeline Nahnsen et.al63 https://nf-co.re/pipelines/ StringTie 2.2.1 N/A https://ccb.jhu.edu/software/stringtie/ MACS2 2.2.7.1 PYPI https://pypi.org/project/MACS2/ ImageJ 1.54 ImageJ https://imagej.net/ij/ R 3.6.3 R Consortim https://www.r-project.org/ LAS X Leica N/A GraphPad Prism 9 GraphPad https://www.graphpad.com/resources Other TCS SP8 confocal microscope Leica Leica TCS SP8 Upright Microscopes Leica Leica DM6 B Cell Reports 45, 118169, November 24, 2026 17 performed.



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