trap5b (Novus Biologicals)
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trap5b
Trap5b, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/trap+kit/Mouse+TRACP%2FPAP%2FACP5+ELISA+Kit+(Colorimetric)/pmc11653010-104-12-3
Average 93 stars, based on 1 article reviews
Trap5b, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/trap+kit/Mouse+TRACP%2FPAP%2FACP5+ELISA+Kit+(Colorimetric)/pmc11653010-104-12-3
Average 93 stars, based on 1 article reviews
trap5b - by Bioz Stars,
2026-11
93/100 stars
Images
1) Product Images from "Geranylgeranyl diphosphate synthase inhibition impairs osteoclast differentiation, morphology, and resorptive activity"
Article Title: Geranylgeranyl diphosphate synthase inhibition impairs osteoclast differentiation, morphology, and resorptive activity
Journal: JBMR Plus
doi: 10.1093/jbmrpl/ziae133
Figure Legend Snippet: RAM2061 does not significantly impact normal bone remodeling in CD-1 mice. (A) Schematic representation of drug administration/dosing and downstream readouts conducted. Abbreviations: procollagen type 1 N-propeptide (P1NP); C-terminal telopeptide (CTX), tartrate resistant acid phosphatase 5b (TRAP5b). (B) Immunoblot analysis of unmodified Rap1a and GAPDH (loading control) using 30 μL of bone homogenate from long bones of mice; positive control = cell lysate from RAW264.7 osteoclasts (D5) treated with 400 nM RAM2061 for 48 h). (C) Quantification of RAM2061 accumulation in long bones and mandibles of CD-1 mice ( n = 5 per group, data are represented as mean ± SD). (D) MicroCT analysis portraying morphometric analysis of the proximal tibia specimens. Individual data points are shown with mean ± SD (PBS n = 5; RAM2061 n = 5; zoledronic acid (ZA) n = 4; * denotes p <.05, ** denotes p <.01 per t-test). (E) The growth plate in the distal femur of tartrate resistant acid phosphatase (TRAP)-stained sections were identified and 1000 μm from the most distal area was used to encapsulate the area of interest. Quantification of osteoclast numbers in the defined area per femur was performed. Individual data points are shown with mean ± SD (PBS n = 5; RAM2061 n = 4; ZA n = 4, * denotes p<.05, *** denotes p <.001 per t-test). (F) Representative images of TRAP-stained sections of distal femurs (scale bar = 50 μm). The arrows indicate TRAP+ osteoclasts (Tb = trabecular bone, BM = bone marrow).
Techniques Used: Western Blot, Control, Positive Control, Staining
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