Review




Structured Review

Spatial Transcriptomics Inc mouse olfactory bulb st data
Analysis of <t>mouse</t> <t>olfactory</t> <t>bulb</t> <t>data.</t> a) H&E staining of the olfactory bulb (top) and the deconvolution results of all candidate methods displayed by the spatial scatter pie plot of cell‐type composition on each spatial location. The examined cell types were granule cells (GC), olfactory sensory neurons (OSNs), periglomerular cells (PGC), mitral/tufted cells (M‐TC), and external plexiform layer interneurons (EPL‐IN) b) Manual annotation of anatomic layers (top), including the granule cell layer (GCL), the mitral cell layer (MCL), the glomerular layer (GL), and the nerve layer (ONL), and the spatial domains of different deconvolution methods visualized by spatial scatters of specific domain types. c) Performance comparison between candidate deconvolution methods, including QR‐SIDE, STdeconvolve, CARDfree, RCTD, CARD, SPOTlight, and spatialDWLS in terms of NMI (left) and ARI (right). d) UMAP plots of gene expression for Topic 1, 2, 3 identified by QR‐SIDE. The color scheme of each topic domain was the same as in (b). e) The heatmap of normalized expression level for the top 10 DE genes for topic domain 1, 2, 3. f) The correlation between DE genes of identified domains and marker genes of each cell type. g) The mean expression level of an example marker gene list for QR‐SIDE, where Tyro3 was included as the interference marker gene of cell type GC. h) Left and middle panels: The estimated spot‐separable η scores of correct marker Penk and misclassified marker Tyro3 . Right panel: The line plots of mean η of all markers across all spatial spots and the RMSE between estimated cell‐type composition by varying the inclusion of top 3‐7 marker genes of each cell type as the input gene list and the deconvolution results using high‐quality marker genes (as shown in a).
Mouse Olfactory Bulb St Data, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pmc12103236-331-3-9?v=Spatial+Transcriptomics+Inc
Average 86 stars, based on 1 article reviews
mouse olfactory bulb st data - by Bioz Stars, 2026-08
86/100 stars

Images

1) Product Images from "Robust Spatial Cell‐Type Deconvolution with Qualitative Reference for Spatial Transcriptomics"

Article Title: Robust Spatial Cell‐Type Deconvolution with Qualitative Reference for Spatial Transcriptomics

Journal: Small Methods

doi: 10.1002/smtd.202401145

Analysis of mouse olfactory bulb data. a) H&E staining of the olfactory bulb (top) and the deconvolution results of all candidate methods displayed by the spatial scatter pie plot of cell‐type composition on each spatial location. The examined cell types were granule cells (GC), olfactory sensory neurons (OSNs), periglomerular cells (PGC), mitral/tufted cells (M‐TC), and external plexiform layer interneurons (EPL‐IN) b) Manual annotation of anatomic layers (top), including the granule cell layer (GCL), the mitral cell layer (MCL), the glomerular layer (GL), and the nerve layer (ONL), and the spatial domains of different deconvolution methods visualized by spatial scatters of specific domain types. c) Performance comparison between candidate deconvolution methods, including QR‐SIDE, STdeconvolve, CARDfree, RCTD, CARD, SPOTlight, and spatialDWLS in terms of NMI (left) and ARI (right). d) UMAP plots of gene expression for Topic 1, 2, 3 identified by QR‐SIDE. The color scheme of each topic domain was the same as in (b). e) The heatmap of normalized expression level for the top 10 DE genes for topic domain 1, 2, 3. f) The correlation between DE genes of identified domains and marker genes of each cell type. g) The mean expression level of an example marker gene list for QR‐SIDE, where Tyro3 was included as the interference marker gene of cell type GC. h) Left and middle panels: The estimated spot‐separable η scores of correct marker Penk and misclassified marker Tyro3 . Right panel: The line plots of mean η of all markers across all spatial spots and the RMSE between estimated cell‐type composition by varying the inclusion of top 3‐7 marker genes of each cell type as the input gene list and the deconvolution results using high‐quality marker genes (as shown in a).
Figure Legend Snippet: Analysis of mouse olfactory bulb data. a) H&E staining of the olfactory bulb (top) and the deconvolution results of all candidate methods displayed by the spatial scatter pie plot of cell‐type composition on each spatial location. The examined cell types were granule cells (GC), olfactory sensory neurons (OSNs), periglomerular cells (PGC), mitral/tufted cells (M‐TC), and external plexiform layer interneurons (EPL‐IN) b) Manual annotation of anatomic layers (top), including the granule cell layer (GCL), the mitral cell layer (MCL), the glomerular layer (GL), and the nerve layer (ONL), and the spatial domains of different deconvolution methods visualized by spatial scatters of specific domain types. c) Performance comparison between candidate deconvolution methods, including QR‐SIDE, STdeconvolve, CARDfree, RCTD, CARD, SPOTlight, and spatialDWLS in terms of NMI (left) and ARI (right). d) UMAP plots of gene expression for Topic 1, 2, 3 identified by QR‐SIDE. The color scheme of each topic domain was the same as in (b). e) The heatmap of normalized expression level for the top 10 DE genes for topic domain 1, 2, 3. f) The correlation between DE genes of identified domains and marker genes of each cell type. g) The mean expression level of an example marker gene list for QR‐SIDE, where Tyro3 was included as the interference marker gene of cell type GC. h) Left and middle panels: The estimated spot‐separable η scores of correct marker Penk and misclassified marker Tyro3 . Right panel: The line plots of mean η of all markers across all spatial spots and the RMSE between estimated cell‐type composition by varying the inclusion of top 3‐7 marker genes of each cell type as the input gene list and the deconvolution results using high‐quality marker genes (as shown in a).

Techniques Used: Staining, Comparison, Gene Expression, Expressing, Marker



Similar Products

86
10X Genomics transcriptome st data
Transcriptome St Data, supplied by 10X Genomics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pm42121254-153-2-14?v=10X+Genomics
Average 86 stars, based on 1 article reviews
transcriptome st data - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier

86
Spatial Transcriptomics Inc spatial transcriptomics st data
Spatial Transcriptomics St Data, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pm41610146-199-7-7?v=Spatial+Transcriptomics+Inc
Average 86 stars, based on 1 article reviews
spatial transcriptomics st data - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier

86
Spatial Transcriptomics Inc visium spatial transcriptomics st
Visium Spatial Transcriptomics St, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pm41592568-773-7-8?v=Spatial+Transcriptomics+Inc
Average 86 stars, based on 1 article reviews
visium spatial transcriptomics st - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier

86
Spatial Transcriptomics Inc spatial transcriptomics st
Spatial Transcriptomics St, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pmc12857762-212-0-0?v=Spatial+Transcriptomics+Inc
Average 86 stars, based on 1 article reviews
spatial transcriptomics st - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier

86
Spatial Transcriptomics Inc spatial transcriptomics st technologies
Spatial Transcriptomics St Technologies, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pm41611568-21-0-0?v=Spatial+Transcriptomics+Inc
Average 86 stars, based on 1 article reviews
spatial transcriptomics st technologies - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier

86
Spatial Transcriptomics Inc transcriptomics st links tissue morphology
Transcriptomics St Links Tissue Morphology, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pm41545411-0-2-1?v=Spatial+Transcriptomics+Inc
Average 86 stars, based on 1 article reviews
transcriptomics st links tissue morphology - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier

86
Spatial Transcriptomics Inc breast cancer spatial transcriptomics st
Spatial organization and cell-cell communication networks in the tumor microenvironment. (A–C) The developmental trajectories of cell sub-populations from a spatial perspective are investigated. (D, E) Heatmap and network diagrams displaying cell–cell dependency analysis in the colocated, neighboring, and extended neighboring (15-point) regions of the spatial <t>transcriptomics</t> data. (F) The interaction heatmap visualized the intensity of intercellular interactions mediated by the ligand-receptor pairs. (G) The spatial cell communication network diagram illustrates that NUhighepi exhibit a higher intensity of cell communication with other cells. (H) Circos plot summarizing cell-type-specific interaction patterns.
Breast Cancer Spatial Transcriptomics St, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/transcriptomics+st/pmc12847018-99-0-2?v=Spatial+Transcriptomics+Inc
Average 86 stars, based on 1 article reviews
breast cancer spatial transcriptomics st - by Bioz Stars, 2026-08
86/100 stars
  Buy from Supplier

Image Search Results


Spatial organization and cell-cell communication networks in the tumor microenvironment. (A–C) The developmental trajectories of cell sub-populations from a spatial perspective are investigated. (D, E) Heatmap and network diagrams displaying cell–cell dependency analysis in the colocated, neighboring, and extended neighboring (15-point) regions of the spatial transcriptomics data. (F) The interaction heatmap visualized the intensity of intercellular interactions mediated by the ligand-receptor pairs. (G) The spatial cell communication network diagram illustrates that NUhighepi exhibit a higher intensity of cell communication with other cells. (H) Circos plot summarizing cell-type-specific interaction patterns.

Journal: Frontiers in Oncology

Article Title: Spatial transcriptome and single-cell sequencing reveal the role of nucleotide metabolism in breast cancer progression and tumor microenvironment

doi: 10.3389/fonc.2025.1703778

Figure Lengend Snippet: Spatial organization and cell-cell communication networks in the tumor microenvironment. (A–C) The developmental trajectories of cell sub-populations from a spatial perspective are investigated. (D, E) Heatmap and network diagrams displaying cell–cell dependency analysis in the colocated, neighboring, and extended neighboring (15-point) regions of the spatial transcriptomics data. (F) The interaction heatmap visualized the intensity of intercellular interactions mediated by the ligand-receptor pairs. (G) The spatial cell communication network diagram illustrates that NUhighepi exhibit a higher intensity of cell communication with other cells. (H) Circos plot summarizing cell-type-specific interaction patterns.

Article Snippet: Breast cancer spatial transcriptomics (ST) data were acquired from the GEO database ( https://www.ncbi.nlm.nih.gov/geo/ ) and 10x Genomics official website ( https://www.10xgenomics.com/ ).

Techniques: