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mouse soleus muscle transcriptomic and epigenomic data  (GeneLAB GmbH)

 
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    GeneLAB GmbH mouse soleus muscle transcriptomic and epigenomic data
    Genelab datasets analyzed in the manuscript.
    Mouse Soleus Muscle Transcriptomic And Epigenomic Data, supplied by GeneLAB GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/transcriptomic+and+epigenomic+data/transcriptome+dataset/pmc11166946-5-2-23
    Average 90 stars, based on 1 article reviews
    mouse soleus muscle transcriptomic and epigenomic data - by Bioz Stars, 2026-11
    90/100 stars

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    1) Product Images from "Aging and putative frailty biomarkers are altered by spaceflight"

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight

    Journal: Scientific Reports

    doi: 10.1038/s41598-024-57948-5

    Genelab datasets analyzed in the manuscript.
    Figure Legend Snippet: Genelab datasets analyzed in the manuscript.

    Techniques Used: Gene Expression, Expressing, Biomarker Discovery, Irradiation

    Related Articles

    other:

    Article Title: Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs
    Article Snippet: The transcriptome dataset of hiPSC‐CMs used in this study was sourced from NASA's GeneLab platform (genelab.nasa.gov) [ ].

    Article Title: Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome.
    Article Snippet: We have therefore imported 15 spaceflight-related plant transcriptome datasets from the GeneLab data repository and manually curated the associated metadata to develop a metadata matrix (hereafter, the Matrix).

    Article Title: Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs.
    Article Snippet: The transcriptome dataset of hiPSC-CMs used in this study was sourced from NASA’s GeneLab platform (genelab.nasa.gov) [9].

    RNA Sequencing:

    Article Title: Batch effect correction methods for NASA GeneLab transcriptomic datasets
    Article Snippet: .. In the present work, we utilized publicly available transcriptomics data sourced from NASA GeneLab to evaluate the performance of five common batch effect correction methods (ComBat and ComBat-seq from the sva R package, and Median Polish, Empirical Bayes, and ANOVA from the MBatch R package) on combined RNA sequencing (RNA-seq) datasets. .. As part of the NASA Open Science Data Repository (https://osdr.nasa.gov/bio/ repo/), GeneLab is an open access database that hosts datasets containing both raw and processed multi-omics data from spaceflight and ground-based analogue experiments (Ray et al., 2019; Berrios et al., 2021).

    Biomarker Discovery:

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight
    Article Snippet: OSD-104 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse soleus muscle transcriptomic and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/em9r-w619 , Soleus muscle. .. OSD-105 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse tibialis anterior muscle transcriptomic, proteomic, and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/xgw6-6t64 , Tibialis anterior muscle. .. OSD-195 , Effects of 21 days of bedrest on human skeletal muscle gene expression , Rullman E. "Effects of 21 days of bedrest on human skeletal muscle gene expression", NASA Open Science Data Repository, Version 1, http://doi.org/10.26030/r6bv-rk07 , Vastus lateralis muscle.

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight
    Article Snippet: OSD-99 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse extensor digitorum longus muscle transcriptomic and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/1h3m-3q49 , Extensor digitorum longus muscle. .. OSD-101 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse left gastrocnemius muscle transcriptomic, proteomic, and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 5, http://doi.org/10.26030/sdmt-ae51 , Gastrocnemius muscle. .. OSD-103 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse quadriceps muscle transcriptomic, proteomic, and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/9vzk-b116 , Quadriceps muscle.

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight
    Article Snippet: OSD-103 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse quadriceps muscle transcriptomic, proteomic, and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/9vzk-b116 , Quadriceps muscle. .. OSD-104 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse soleus muscle transcriptomic and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/em9r-w619 , Soleus muscle. .. OSD-105 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse tibialis anterior muscle transcriptomic, proteomic, and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/xgw6-6t64 , Tibialis anterior muscle.



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    Functional impact of RB1 mutation on mRNA expression in Bladder Cancer. ( A ) In the <t>TCGA</t> BLCA (Bladder urothelial carcinoma) cohort, 1518 genes showed significant up-regulation (dark red dots, FDR < 0.01) in RB1 mutated samples whereas 1294 genes showed significant down-regulation (dark green dots, FDR < 0.01). ( B ) Among the most significant genes, up-regulation was found for CDKN2A and E2F1 (positive rank #1 and #22) whereas down-regulation was found for RB1 and CCND1 (negative rank #1 and #29). ( C ) The 1518 up-regulated genes were significantly enriched with transcriptional targets of E2F1 (Fisher's exact test, top 10 most enriched target sets).
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    Image Search Results


    Genelab datasets analyzed in the manuscript.

    Journal: Scientific Reports

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight

    doi: 10.1038/s41598-024-57948-5

    Figure Lengend Snippet: Genelab datasets analyzed in the manuscript.

    Article Snippet: OSD-99 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse extensor digitorum longus muscle transcriptomic and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/1h3m-3q49 , Extensor digitorum longus muscle.

    Techniques: Gene Expression, Expressing, Biomarker Discovery, Irradiation

    Genelab datasets analyzed in the manuscript.

    Journal: Scientific Reports

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight

    doi: 10.1038/s41598-024-57948-5

    Figure Lengend Snippet: Genelab datasets analyzed in the manuscript.

    Article Snippet: OSD-105 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse tibialis anterior muscle transcriptomic, proteomic, and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/xgw6-6t64 , Tibialis anterior muscle.

    Techniques: Gene Expression, Expressing, Biomarker Discovery, Irradiation

    Genelab datasets analyzed in the manuscript.

    Journal: Scientific Reports

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight

    doi: 10.1038/s41598-024-57948-5

    Figure Lengend Snippet: Genelab datasets analyzed in the manuscript.

    Article Snippet: OSD-104 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse soleus muscle transcriptomic and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 4, http://doi.org/10.26030/em9r-w619 , Soleus muscle.

    Techniques: Gene Expression, Expressing, Biomarker Discovery, Irradiation

    Genelab datasets analyzed in the manuscript.

    Journal: Scientific Reports

    Article Title: Aging and putative frailty biomarkers are altered by spaceflight

    doi: 10.1038/s41598-024-57948-5

    Figure Lengend Snippet: Genelab datasets analyzed in the manuscript.

    Article Snippet: OSD-101 , Rodent Research-1 (RR1) NASA Validation Flight: Mouse left gastrocnemius muscle transcriptomic, proteomic, and epigenomic data , Galazka J, Globus R "Rodent Research 1", GeneLab, Version 5, http://doi.org/10.26030/sdmt-ae51 , Gastrocnemius muscle.

    Techniques: Gene Expression, Expressing, Biomarker Discovery, Irradiation

    Functional impact of RB1 mutation on mRNA expression in Bladder Cancer. ( A ) In the TCGA BLCA (Bladder urothelial carcinoma) cohort, 1518 genes showed significant up-regulation (dark red dots, FDR < 0.01) in RB1 mutated samples whereas 1294 genes showed significant down-regulation (dark green dots, FDR < 0.01). ( B ) Among the most significant genes, up-regulation was found for CDKN2A and E2F1 (positive rank #1 and #22) whereas down-regulation was found for RB1 and CCND1 (negative rank #1 and #29). ( C ) The 1518 up-regulated genes were significantly enriched with transcriptional targets of E2F1 (Fisher's exact test, top 10 most enriched target sets).

    Journal: Nucleic Acids Research

    Article Title: LinkedOmics: analyzing multi-omics data within and across 32 cancer types

    doi: 10.1093/nar/gkx1090

    Figure Lengend Snippet: Functional impact of RB1 mutation on mRNA expression in Bladder Cancer. ( A ) In the TCGA BLCA (Bladder urothelial carcinoma) cohort, 1518 genes showed significant up-regulation (dark red dots, FDR < 0.01) in RB1 mutated samples whereas 1294 genes showed significant down-regulation (dark green dots, FDR < 0.01). ( B ) Among the most significant genes, up-regulation was found for CDKN2A and E2F1 (positive rank #1 and #22) whereas down-regulation was found for RB1 and CCND1 (negative rank #1 and #29). ( C ) The 1518 up-regulated genes were significantly enriched with transcriptional targets of E2F1 (Fisher's exact test, top 10 most enriched target sets).

    Article Snippet: Genomic, epigenomic, and transcriptomic data for 32 TCGA cancer types were downloaded from the Firehose of the Broad Institute ( http://gdac.broadinstitute.org/ , January 2016 version).

    Techniques: Functional Assay, Mutagenesis, Expressing

    Pan-cancer analysis for survival-associated gene expression signatures. ( A ) Twelve cancer types in the TCGA project with >100 death events. ( B ) The heat map shows the top 30 poor survival-associated genes. Each cell represents the signed –log 10 ( P -value). The right panel bar plot depicts corresponding meta-analysis based FDR. A and B share the same order of cancer types, as indicated below the heat map. ( C ) Increased expression of genes in the cell cycle pathway is associated with increased death risk (FDR<0.001, gene set enrichment analysis). Leading-edge genes are highlighted in red boxes in C. ( D–G ) Patients with above- (red) and below- (green) median APCDD1L mRNA abundance had significantly different survival rates in multiple cancer types such as bladder urothelial carcinoma (BLCA, D), head and neck squamous cell carcinoma (HNSC, E), kidney renal clear cell carcinoma (KIRC, F), and brain lower grade glioma (LGG, G).

    Journal: Nucleic Acids Research

    Article Title: LinkedOmics: analyzing multi-omics data within and across 32 cancer types

    doi: 10.1093/nar/gkx1090

    Figure Lengend Snippet: Pan-cancer analysis for survival-associated gene expression signatures. ( A ) Twelve cancer types in the TCGA project with >100 death events. ( B ) The heat map shows the top 30 poor survival-associated genes. Each cell represents the signed –log 10 ( P -value). The right panel bar plot depicts corresponding meta-analysis based FDR. A and B share the same order of cancer types, as indicated below the heat map. ( C ) Increased expression of genes in the cell cycle pathway is associated with increased death risk (FDR<0.001, gene set enrichment analysis). Leading-edge genes are highlighted in red boxes in C. ( D–G ) Patients with above- (red) and below- (green) median APCDD1L mRNA abundance had significantly different survival rates in multiple cancer types such as bladder urothelial carcinoma (BLCA, D), head and neck squamous cell carcinoma (HNSC, E), kidney renal clear cell carcinoma (KIRC, F), and brain lower grade glioma (LGG, G).

    Article Snippet: Genomic, epigenomic, and transcriptomic data for 32 TCGA cancer types were downloaded from the Firehose of the Broad Institute ( http://gdac.broadinstitute.org/ , January 2016 version).

    Techniques: Gene Expression, Expressing