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human tissue microarray (tma) sections  (Biomax Inc)

 
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    Biomax Inc human tissue microarray (tma) sections
    USP13 is highly amplified in NSCLC and associated with poor survival. A Genomic alteration frequency of USP13 gene in multiple cancer types. B Oncoprint mutation profile of KRAS , TP53 , USP13 , SOX2, and TP63 in LUSC (top) and LUAD (bottom). USP13 , SOX2, and TP63 genes are co-amplified in NSCLC. C The correlation between mRNA expression and copy number variations (CNVs) of USP13 in LUSC (left) and LUAD (right). D Kaplan-Meier plots of NSCLC patients stratified by USP13 expression: Overall survival (top) and relapse-free survival (bottom) in LUSC (left) and LUAD (right). p- values were calculated using the log-rank test. E USP13 protein level in human LUSC. Representative IHC-staining images in a tissue <t>microarray</t> of adjacent normal tissue and LUSC (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUSC ( n= 75) and normal tissues ( n= 75) (bottom, left). USP13 expression levels in different LUSC grades (bottom, right). Grade 1 ( n= 5), grade 2 ( n= 50) and grade 3 ( n= 20). F USP13 protein level in human LUAD. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUAD (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUAD ( n= 75) and normal tissues ( n= 75) (bottom left). USP13 expression levels in different LUAD grades (bottom, right). Grade 1 ( n= 11), grade 2 ( n= 45) and grade 3 ( n= 19). a.u., arbitrary unit. In ( C ), ( E ), and ( F ), boxes indicate the 10-90 percentile. Two-tailed unpaired t-tests, ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001
    Human Tissue Microarray (Tma) Sections, supplied by Biomax Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tma+tissue+sections/tissue+microarray/pmc10717271-61-0-8
    Average 90 stars, based on 1 article reviews
    human tissue microarray (tma) sections - by Bioz Stars, 2026-10
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    Images

    1) Product Images from "USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity"

    Article Title: USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity

    Journal: Molecular Cancer

    doi: 10.1186/s12943-023-01892-x

    USP13 is highly amplified in NSCLC and associated with poor survival. A Genomic alteration frequency of USP13 gene in multiple cancer types. B Oncoprint mutation profile of KRAS , TP53 , USP13 , SOX2, and TP63 in LUSC (top) and LUAD (bottom). USP13 , SOX2, and TP63 genes are co-amplified in NSCLC. C The correlation between mRNA expression and copy number variations (CNVs) of USP13 in LUSC (left) and LUAD (right). D Kaplan-Meier plots of NSCLC patients stratified by USP13 expression: Overall survival (top) and relapse-free survival (bottom) in LUSC (left) and LUAD (right). p- values were calculated using the log-rank test. E USP13 protein level in human LUSC. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUSC (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUSC ( n= 75) and normal tissues ( n= 75) (bottom, left). USP13 expression levels in different LUSC grades (bottom, right). Grade 1 ( n= 5), grade 2 ( n= 50) and grade 3 ( n= 20). F USP13 protein level in human LUAD. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUAD (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUAD ( n= 75) and normal tissues ( n= 75) (bottom left). USP13 expression levels in different LUAD grades (bottom, right). Grade 1 ( n= 11), grade 2 ( n= 45) and grade 3 ( n= 19). a.u., arbitrary unit. In ( C ), ( E ), and ( F ), boxes indicate the 10-90 percentile. Two-tailed unpaired t-tests, ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001
    Figure Legend Snippet: USP13 is highly amplified in NSCLC and associated with poor survival. A Genomic alteration frequency of USP13 gene in multiple cancer types. B Oncoprint mutation profile of KRAS , TP53 , USP13 , SOX2, and TP63 in LUSC (top) and LUAD (bottom). USP13 , SOX2, and TP63 genes are co-amplified in NSCLC. C The correlation between mRNA expression and copy number variations (CNVs) of USP13 in LUSC (left) and LUAD (right). D Kaplan-Meier plots of NSCLC patients stratified by USP13 expression: Overall survival (top) and relapse-free survival (bottom) in LUSC (left) and LUAD (right). p- values were calculated using the log-rank test. E USP13 protein level in human LUSC. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUSC (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUSC ( n= 75) and normal tissues ( n= 75) (bottom, left). USP13 expression levels in different LUSC grades (bottom, right). Grade 1 ( n= 5), grade 2 ( n= 50) and grade 3 ( n= 20). F USP13 protein level in human LUAD. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUAD (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUAD ( n= 75) and normal tissues ( n= 75) (bottom left). USP13 expression levels in different LUAD grades (bottom, right). Grade 1 ( n= 11), grade 2 ( n= 45) and grade 3 ( n= 19). a.u., arbitrary unit. In ( C ), ( E ), and ( F ), boxes indicate the 10-90 percentile. Two-tailed unpaired t-tests, ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

    Techniques Used: Amplification, Mutagenesis, Expressing, Immunohistochemistry, Microarray, Two Tailed Test

    Related Articles

    Immunohistochemistry:

    Article Title: Neurotrophin-3 Facilitates Stemness Properties and Associates with Poor Survival in Lung Cancer.
    Article Snippet: Introduction: Cancer stem cells (CSCs) shape the tumor microenvironment via neuroendocrine signaling and orchestrate drug resistance and metastasis.. Cytokine antibody array demonstrated the upregulation of neurotrophin-3 (NT-3) in lung CSCs.. This study aims to dissect the role of NT-3 in lung CSCs during tumor innervation.

    Article Title: Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights
    Article Snippet: .. However, our PTPN7 IHC data are derived from tissue microarrays (BioMax, https://www.tissuearray.com/tissue-arrays/Brain/GL1001a ) and the RNA‐Seq data from TCGA ( https://portal.gdc.cancer.gov/ ), making direct comparisons challenging. ..

    Microarray:

    Article Title: Neurotrophin-3 Facilitates Stemness Properties and Associates with Poor Survival in Lung Cancer.
    Article Snippet: Introduction: Cancer stem cells (CSCs) shape the tumor microenvironment via neuroendocrine signaling and orchestrate drug resistance and metastasis.. Cytokine antibody array demonstrated the upregulation of neurotrophin-3 (NT-3) in lung CSCs.. This study aims to dissect the role of NT-3 in lung CSCs during tumor innervation.

    Article Title: Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma.
    Article Snippet: Funding information National Cancer Institute, Grant/Award Number: ZIA BC 011513 Abstract Carbonic anhydrase-9 (CA9) is highly expressed in clear cell renal cell carcinoma (ccRCC) cells despite no expression in normal kidney tissues.. Thus, CA9 has been proposed as a theranostic target for radioligand therapy (RLT).. However, ccRCC tends to be radioresistant and may not effectively respond to RLT.

    Article Title: Multiphoton excited polymerized biomimetic models of collagen fiber morphology to study single cell and collective migration dynamics in pancreatic cancer.
    Article Snippet: The respective roles of aligned collagen fiber morphology found in the extracellular matrix (ECM) of pancreatic cancer patients and cellular migration dynamics have been gaining attention because of their connection with increased aggressive phenotypes and poor prognosis.. To better understand how collagen fiber morphology influences cell-matrix interactions associated with metastasis, we used Second Harmonic Generation (SHG) images from patient biopsies with Pancreatic ductal adenocarcinoma (PDAC) as models to fabricate collagen scaffolds to investigate processes associated with motility.. Using the PDAC BxPC-3 metastatic cell line, we investigated single and collective cell dynamics on scaffolds of varying collagen alignment.

    Derivative Assay:

    Article Title: Multiphoton excited polymerized biomimetic models of collagen fiber morphology to study single cell and collective migration dynamics in pancreatic cancer.
    Article Snippet: The respective roles of aligned collagen fiber morphology found in the extracellular matrix (ECM) of pancreatic cancer patients and cellular migration dynamics have been gaining attention because of their connection with increased aggressive phenotypes and poor prognosis.. To better understand how collagen fiber morphology influences cell-matrix interactions associated with metastasis, we used Second Harmonic Generation (SHG) images from patient biopsies with Pancreatic ductal adenocarcinoma (PDAC) as models to fabricate collagen scaffolds to investigate processes associated with motility.. Using the PDAC BxPC-3 metastatic cell line, we investigated single and collective cell dynamics on scaffolds of varying collagen alignment.

    Article Title: Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights
    Article Snippet: .. However, our PTPN7 IHC data are derived from tissue microarrays (BioMax, https://www.tissuearray.com/tissue-arrays/Brain/GL1001a ) and the RNA‐Seq data from TCGA ( https://portal.gdc.cancer.gov/ ), making direct comparisons challenging. ..

    Expressing:

    Article Title: PPIA enhances cell growth and metastasis through CD147 in oral cancer.
    Article Snippet: Oral cancer is a malignant tumor, and the associated death rate has significantly increased over the past few decades.. Secreted fractions are involved in various physiological processes, and their analysis has become a promising approach for discovering diagnostic and prognostic biomarkers for cancer detection and monitoring metastasis.. Therefore, the discovery of potential prognostic, diagnostic, and therapeutic biomarkers for oral cancer metastasis is beneficial for developing effective strategies in oral cancer therapy.

    other:

    Article Title: AI system for diagnosing mucosa-associated lymphoid tissue lymphoma and diffuse large B cell lymphoma using ImageNet and hematoxylin and eosin–stained specimens
    Article Snippet: This study analyzed data from 160 patients, comprising 25 normal lymph nodes (NL), 26 MALT lymphoma, 31 GCB, and 78 non-GCB cases purchased from Biomax tissue microarrays (TMAs) (Fig. and Table ).

    Article Title: TET2 promotes tumor antigen presentation and T cell IFN- γ , which is enhanced by vitamin C
    Article Snippet: For human samples, all tumor microarrays were purchased from Biomax (see above).

    Formalin-fixed Paraffin-Embedded:




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    USP13 is highly amplified in NSCLC and associated with poor survival. A Genomic alteration frequency of USP13 gene in multiple cancer types. B Oncoprint mutation profile of KRAS , TP53 , USP13 , SOX2, and TP63 in LUSC (top) and LUAD (bottom). USP13 , SOX2, and TP63 genes are co-amplified in NSCLC. C The correlation between mRNA expression and copy number variations (CNVs) of USP13 in LUSC (left) and LUAD (right). D Kaplan-Meier plots of NSCLC patients stratified by USP13 expression: Overall survival (top) and relapse-free survival (bottom) in LUSC (left) and LUAD (right). p- values were calculated using the log-rank test. E USP13 protein level in human LUSC. Representative IHC-staining images in a tissue <t>microarray</t> of adjacent normal tissue and LUSC (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUSC ( n= 75) and normal tissues ( n= 75) (bottom, left). USP13 expression levels in different LUSC grades (bottom, right). Grade 1 ( n= 5), grade 2 ( n= 50) and grade 3 ( n= 20). F USP13 protein level in human LUAD. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUAD (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUAD ( n= 75) and normal tissues ( n= 75) (bottom left). USP13 expression levels in different LUAD grades (bottom, right). Grade 1 ( n= 11), grade 2 ( n= 45) and grade 3 ( n= 19). a.u., arbitrary unit. In ( C ), ( E ), and ( F ), boxes indicate the 10-90 percentile. Two-tailed unpaired t-tests, ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001
    Human Tma (Tissue Microarray) Paraffin Sections Human Breast Carcinoma, supplied by U.S Biomax Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    USP13 is highly amplified in NSCLC and associated with poor survival. A Genomic alteration frequency of USP13 gene in multiple cancer types. B Oncoprint mutation profile of KRAS , TP53 , USP13 , SOX2, and TP63 in LUSC (top) and LUAD (bottom). USP13 , SOX2, and TP63 genes are co-amplified in NSCLC. C The correlation between mRNA expression and copy number variations (CNVs) of USP13 in LUSC (left) and LUAD (right). D Kaplan-Meier plots of NSCLC patients stratified by USP13 expression: Overall survival (top) and relapse-free survival (bottom) in LUSC (left) and LUAD (right). p- values were calculated using the log-rank test. E USP13 protein level in human LUSC. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUSC (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUSC ( n= 75) and normal tissues ( n= 75) (bottom, left). USP13 expression levels in different LUSC grades (bottom, right). Grade 1 ( n= 5), grade 2 ( n= 50) and grade 3 ( n= 20). F USP13 protein level in human LUAD. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUAD (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUAD ( n= 75) and normal tissues ( n= 75) (bottom left). USP13 expression levels in different LUAD grades (bottom, right). Grade 1 ( n= 11), grade 2 ( n= 45) and grade 3 ( n= 19). a.u., arbitrary unit. In ( C ), ( E ), and ( F ), boxes indicate the 10-90 percentile. Two-tailed unpaired t-tests, ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

    Journal: Molecular Cancer

    Article Title: USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity

    doi: 10.1186/s12943-023-01892-x

    Figure Lengend Snippet: USP13 is highly amplified in NSCLC and associated with poor survival. A Genomic alteration frequency of USP13 gene in multiple cancer types. B Oncoprint mutation profile of KRAS , TP53 , USP13 , SOX2, and TP63 in LUSC (top) and LUAD (bottom). USP13 , SOX2, and TP63 genes are co-amplified in NSCLC. C The correlation between mRNA expression and copy number variations (CNVs) of USP13 in LUSC (left) and LUAD (right). D Kaplan-Meier plots of NSCLC patients stratified by USP13 expression: Overall survival (top) and relapse-free survival (bottom) in LUSC (left) and LUAD (right). p- values were calculated using the log-rank test. E USP13 protein level in human LUSC. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUSC (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUSC ( n= 75) and normal tissues ( n= 75) (bottom, left). USP13 expression levels in different LUSC grades (bottom, right). Grade 1 ( n= 5), grade 2 ( n= 50) and grade 3 ( n= 20). F USP13 protein level in human LUAD. Representative IHC-staining images in a tissue microarray of adjacent normal tissue and LUAD (top) (scale bar, 200 µm). The red boxed areas on the left images were magnified and shown on the right. Relative USP13 protein levels in LUAD ( n= 75) and normal tissues ( n= 75) (bottom left). USP13 expression levels in different LUAD grades (bottom, right). Grade 1 ( n= 11), grade 2 ( n= 45) and grade 3 ( n= 19). a.u., arbitrary unit. In ( C ), ( E ), and ( F ), boxes indicate the 10-90 percentile. Two-tailed unpaired t-tests, ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

    Article Snippet: Human tissue microarray (TMA) sections were purchased from Biomax (Cat#HLugA150CS02, LUAD; Cat#HLug-Squ150Sur-02, LUSC; Cat#LC2162, NSCLC).

    Techniques: Amplification, Mutagenesis, Expressing, Immunohistochemistry, Microarray, Two Tailed Test